Quick answer

Lab-made anti-aging peptide that promotes firmer skin; Bio-identical to a skin-natural peptide that aids elasticity; Used as part of a blend with butylene glycol and hydroxyethylcellulose; Soothing effect offsets stinging and burning sensations on skin Key benefits: Anti-Aging.

Acetyl Dipeptide-1 Cetyl Ester

Updated

Tyrosine acetate and arginine, hexadecyl ester, dipeptide

Purpose

A lab-made skin-firming peptide formed from a reaction between acetic acid, cetyl alcohol, and dipeptide-1, which contains the amino acids arginine and tyrosine.

Rating

BEST

Category

Peptides

INCI Purpose

HAIR CONDITIONING, SKIN CONDITIONING

Benefits

Anti-Aging — Boosts collagen and cell turnover to reduce fine lines and wrinkles

Alternative Names

At a Glance

Lab-made anti-aging peptide that promotes firmer skin

Bio-identical to a skin-natural peptide that aids elasticity

Used as part of a blend with butylene glycol and hydroxyethylcellulose

Soothing effect offsets stinging and burning sensations on skin

Article

Acetyl dipeptide-1 cetyl ester is a lab-engineered synthetic peptide that combines acetic acid and cetyl alcohol with dipeptide-1, a peptide composed of amino acids arginine and tyrosine. Dipeptide-1 is found naturally in the body and plays a role in maintaining skin’s elasticity.

Research has shown that topical application of this peptide protects collagen-making cells known as fibroblasts from the visible impact of glycation, a process in which destructive sugar molecules progressively weaken skin’s supportive elements.

This ingredient has also been shown to thwart irritation on skin’s surface that would otherwise result in stinging or burning sensations. As such, it’s a very good option to pair with bio-active ingredients that can be more sensitizing for some people.

Recommended usage levels of this peptide range from 3–4%; however, since the peptide portion itself is part of a blend, the actual amount of peptide needed to gain benefit is much lower, in the parts per million level. It is considered safe as used in cosmetics.

References

Pharmaceuticals, July 2021, pages 1–22 Journal of Cosmetic Dermatology, June 2020, pages 1, 415–1, 425 Journal of the European Academy of Dermatology and Venereology, Supplement 1, February 2016, pages 18–20