Quick answer

Potent antioxidant abundant in certain types of mushrooms; Helps skin look younger in multiple ways; Fades signs of discoloration; Offers soothing benefits Key benefits: Anti-Aging, Dark Spot Fading.

Ergothioneine

Updated

Ammonium, [1-carboxy-2-(2-mercaptoimidazol-4-yl)ethyl]trimethyl-, hydroxide, inner salt, L-(+)-

Purpose

Potent, mushroom-derived antioxidant that boosts skin’s environmental defenses and ability to look younger in multiple ways.

Rating

BEST

Category

Antioxidant

INCI Purpose

ANTIOXIDANT

Benefits

Anti-Aging — Boosts collagen and cell turnover to reduce fine lines and wrinkles
Dark Spot Fading — Fades hyperpigmentation and evens out dark spots over time

Alternative Names

At a Glance

Potent antioxidant abundant in certain types of mushrooms

Helps skin look younger in multiple ways

Fades signs of discoloration

Offers soothing benefits

Article

Ergothioneine is a derivative of the amino acid histidine synthesized in nature by various bacteria and fungi. It occurs in most types of mushrooms with naturally high amounts detected in oyster, porcini, portobello, white button and shiitake types. Red beans, black beans, garlic and oat bran are other food sources, but a bio-identical form can be lab-synthesized and has proven to be safe.

Several studies have shown that ergothioneine is a potent antioxidant, capable of helping skin look younger when exposed to environmental stressors and sources of oxidative damage. One of the ways ergothioneine works on skin is by helping to protect its endogenous (naturally occurring) antioxidants from degrading, thus enabling it to maintain its defenses for longer periods of time.

Ergothioneine also has a surface inhibitory effect on an enzyme that plays a role in fueling excess melanin within skin’s uppermost layers. In doing so, ergothioneine plays a supporting role helping to fade discolorations.

Usage levels of ergothioneine in skin care range from 0.1–1% when supplied in a water-based solution with the antioxidant having an activity level of 0.05%–a testimony to this ingredient’s impressive potency.

See: Histidine, Amino Acids

References

Experimental Gerontology, December 2022, pages 1–11 Processes, July 2021, pages 1–13 Redox Biology, June 2021, pages 1–10 International Journal of Molecular Sciences, March 2021, pages 1–11 Experimental Cell Research, March 2021, ePublication Polymers, January 2021, pages 1–9 Oxidative Medicine and Cellular Longevity, 2020, pages 1–13