Quick answer

Occurs naturally in skin; Defends against visible effects of environmental damage; Offers restoring and tone-improving benefits in topical skin care; Composed of three amino acids Key benefits: Anti-Aging.

Glutathione

Updated

Glycine, N-(N-L-.gamma.-glutamyl-L-cysteinyl)-

Purpose

This ingredient, which occurs naturally in skin, has potent antioxidant benefits and serves as a skin-restoring, dullness brightening ingredient in topical products.

Rating

BEST

Category

Antioxidant

INCI Purpose

REDUCING

Benefits

Anti-Aging — Boosts collagen and cell turnover to reduce fine lines and wrinkles

Alternative Names

At a Glance

Occurs naturally in skin

Defends against visible effects of environmental damage

Offers restoring and tone-improving benefits in topical skin care

Composed of three amino acids

Article

Glutathione is a powerful, non-enzymatic antioxidant which naturally occurs in the skin where it serves to help defend it against the visible effects of environmental damage. The gradual decline of the natural supply of glutathione in the body is believed to be a key marker of many outward signs of aging.

Glutathione is a tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine), which work in unison when used topically to brighten a dull complexion while offering skin-restoring benefits. It has value for visibly fading discolorations when used in a 2% concentration due to its ability to interrupt an enzyme within skin’s surface that triggers hyperpigmentation.

Glutathione has also been shown to help stabilize and enhance the performance of other antioxidants such as vitamin C, even when used in low concentrations.

References

Journal of Cosmetic Dermatology, June 2019, pages 728–737 Clinical Cosmetic and Investigative Dermatology, April 2017, pages 147-153 and October 2014, pages 267-274 Nutrients, August 2017, pages 1-27 DermatoEndocrinology, July 2012, pages 308-319 Journal of Agricultural and Food Chemistry, 2011, pages 3, 940-3, 949 The Dermatologist, October 2011, volume 19, issue 10 Journal of Dermatologic Science, May 2010, pages 85-90 Free Radical Biology and Medicine, October 1994, pages 333-349