Quick answer
A synthetic peptide that matches a sequence of amino acids found in skin; Signals skin to look younger by boosting its firm feeling; Creates a supple surface by strengthening skin’s barrier; Requires a surprisingly low amount for efficacy Key benefits: Anti-Aging.
Palmitoyl Hexapeptide-12
Updated
Glycine, N-(1-oxohexadecyl)-L-valylglycyl-L-valyl-L-alanyl-L-prolyl-
Purpose
This lab-made peptide matches a sequence of amino acids found in skin. As such, skin recognizes and can understand the signals the peptide sends, which leads to a smoother, more youthful appearance.
Rating
BEST
Category
Peptides
INCI Purpose
SKIN CONDITIONING
Benefits
Alternative Names
At a Glance
A synthetic peptide that matches a sequence of amino acids found in skin
Signals skin to look younger by boosting its firm feeling
Creates a supple surface by strengthening skin’s barrier
Requires a surprisingly low amount for efficacy
Article
Palmitoyl hexapeptide-12 is a lab-made peptide that blends the fatty acid palmitic acid with several amino acids, including glycine, histidine, and lysine. Combining this specifically engineered peptide with palmitic acid enhances its penetration into skin as well as the peptide’s stability.
In the early days of peptides in skin care it went by the catchall term palmitoyl oligopeptide. The amino acid sequence of this peptide mimics that of peptides naturally occurring in skin, meaning skin recognizes and can readily utilize it.
It works on and within skin’s uppermost layers by influencing key supportive elements in skin that result in a firmer surface and minimized appearance of wrinkles. It also strengthens skin’s barrier by improving moisture retention, leaving skin feeling supple instead of rough. As a signal peptide, it can “tell” skin to look younger.
It is considered safe as used in cosmetics, where its calculated efficacy is in the parts per million range. This translates to very low percentages used in skin care, as low as 0.0000001%; however, research is clear that small amounts of this peptide can produce impressive results.
Palmitoyl hexapeptide-12 is most often used on its own rather than being part of a blend with other peptides, although such blends are available.
See: Palmitoyl Oligopeptide
References