Quick answer

Considered a neurotransmitter-inhibiting peptide (“neuropeptide”); Most famously studied for its ability to visibly minimize expression lines and wrinkle depth; Also noted in research for its ability to hydrate skin and improve firmness; May also have the potential to reduce skin discolorations Key benefits: Anti-Aging, Evens Skin Tone, Hydration.

Pentapeptide-18

Neuropeptides

Updated

Pentapeptide-18 is a synthetic peptide consisting of alanine, glycine, leucine, phenylalanine and tyrosine

Purpose

A “neuropeptide” with promising research backing its ability to visibly reduce the appearance of expression lines and wrinkles.

Rating

GOOD

Category

Peptides

INCI Purpose

SKIN CONDITIONING

Benefits

Anti-Aging — Boosts collagen and cell turnover to reduce fine lines and wrinkles
Evens Skin Tone — Brightens and balances complexion for a more uniform appearance
Hydration — Attracts and locks in moisture to keep skin plump and dewy

Alternative Names

At a Glance

Considered a neurotransmitter-inhibiting peptide (“neuropeptide”)

Most famously studied for its ability to visibly minimize expression lines and wrinkle depth

Also noted in research for its ability to hydrate skin and improve firmness

May also have the potential to reduce skin discolorations

Article

Pentapeptide-18 is a peptide that has been studied for its ability to reduce signs of aging, including minimizing the appearance of expression lines and visibly reducing wrinkle depth. It is often referred to as a “neuropeptide” in scientific literature, with “neuro” referring to nerves.

Pentapeptide-18 is also noted in research for its ability to hydrate skin and improve firmness. It is commonly referenced in research alongside another neuropeptide known as acetyl hexapeptide-8 (or acetyl hexapeptide-3 or agireline), where it has been reported these ingredients have an additive synergistic effect in visibly reducing wrinkles.

Variations of this ingredient exist, based on different sequences of its compounds. One study (funded by Colgate-Palmolive Company and PCA SKIN®) demonstrated that when the amino acid D-tyrosine is added to the pentapeptide-18 configuration, it helps visibly fade dark spots and other forms of uneven tone.

More independent studies are necessary to validate these findings, but it does look promising. This peptide is effective in amounts of 0.025% up to 10%, depending on formulary goals and the amount of peptide present in solution or powder forms which vary between suppliers.

Suppliers of pentapeptide-18 note that it comes as a white to yellowish powder in its raw material form, but it is also available in an aqueous solution. *There are dozens of different pentapeptides used in skin care products. The “penta” portion of pentapeptide-18 refers to its composition of five amino acids.

See: Acetyl Hexapeptide-8

References