Pentapeptide-34 Trifluoroacetate

Synthetic peptide said to help boost skin’s coenzyme Q10 content

May help energize skin’s uppermost layers

Only low levels needed for documented efficacy

Independent research on this peptide is lacking

May help protect skin from air polution damage

Pentapeptide-34 trifluoroacetate is a colorless synthetic peptide also known as Peptide Q10 Biofunctional. That’s because the supplier of this ingredient claims that topical use helps skin boost its supply of the antioxidant coenzyme Q10, which declines with age. In fact, between the ages of 30–80, epidermal levels of this antioxidant can decline as much as 80%!

This peptide may also play a role in helping to energize skin’s surface layers so it looks and feels healthier, with fewer visible lines and wrinkles.

The use level of pentapeptide-34 trifluoroacetate in cosmetics is 0.5% when in a water- and propanediol-based blend (meaning the concentration of the peptide is much lower, since these bio-active ingredients typically show efficacy at the parts-per-million level).

The lack of independent research supporting the supplier claims on this water-soluble peptide is why it’s not rated as highly as some others in this database; however, there’s no reason to be concerned about using this ingredient, since improving skin’s coenzyme Q10 content can help its surface better withstand environmental exposure. This includes helping to protect skin from certain airborne pollutants.