NIOD Copper Amino Isolate Serum 3 1:1

NIOD

Copper Amino Isolate Serum 3 1:1

face serum

Added Last edited

Fit by skin type

General, ingredient-based — not your personalized match.

Dry
57%
Combination (dry)
57%
Balanced
87%
Combination (oily)
83%
Oily
83%

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20
Ingredients
3
Benefits
4
Actives
Find Dupes

A foundational copper peptide (1% GHK-Cu) serum to help restore the look of healthy skin. Plays a comprehensive role in skin aging, helping maintain the look of skin health as the skin ages over time, improving the look of skin aging, minimizing the appearance of fine lines and wrinkles, and promoting natural collagen.

Key Insights

Benefits

3
Anti-Aging
Hydration
Soothing

Active Ingredients

4
Barrier peptides Carrier peptides Hyaluronic acid Signal peptides

Full Ingredients

20 total
WATER GLYCERIN TRIPEPTIDE-29 Barrier peptides COPPER TRIPEPTIDE-1 Carrier peptides PALMITOYL TRIPEPTIDE-1 ACETATE Signal peptides MYRISTOYL NONAPEPTIDE-3 TRIPEPTIDE-2 ACETYL TETRAPEPTIDE-2 SODIUM HYALURONATE CROSSPOLYMER Hyaluronic acid GLYCOGEN PROPANEDIOL PENTYLENE GLYCOL DIMETHYL ISOSORBIDE ETHOXYDIGLYCOL ISOCETETH-20 LEUCONOSTOC/RADISH ROOT FERMENT FILTRATE CAPRYLYL GLYCOL ETHYLHEXYLGLYCERIN PHENOXYETHANOL CHLORPHENESIN

About Copper Amino Isolate Serum 3 1:1

Overview

Copper Amino Isolate Serum 3 1:1 is a lightweight serum from NIOD. The formula is built mainly around firmness signalling and hydration. The ingredient list runs to 20 ingredients, each broken down in full below.

Texture and finish

By its ingredient list the formula reads as light: water and humectants lead, with emollients kept lower in the order. Hydration is handled by Glycerin, Sodium Hyaluronate Crosspolymer and Glycogen, humectants that pull water into the upper layers of skin rather than sealing it there.

What the formula does

Firmness signalling: High. Peptides and growth factors that signal for collagen support, and here that comes from Tripeptide-29, Copper Tripeptide-1, Palmitoyl Tripeptide-1 Acetate and Myristoyl Nonapeptide-3.

Hydration: High. Ingredients that pull and hold water in the upper layers of skin, and here that comes from Glycerin, Sodium Hyaluronate Crosspolymer, Glycogen and Propanediol.

Barrier support: Moderate. Lipids and repair signals that support skin barrier integrity, and here that comes from Tripeptide-29.

Who it suits

On richness alone it suits Balanced, Combination (oily) and Oily skin best, and is the least natural fit for Dry and Combination (dry) skin. Nothing in the list is flagged as a common irritant, which is a reasonable starting point for reactive skin — though a patch test is still the only way to know.

What it does not target

The formula contributes little or nothing on antioxidant protection, oil control, brightening and tone and cell renewal. That is not a fault — most products are not meant to do everything — but if one of those is your priority, this is not the product that will address it.

What is not in it

Reading the full list, the formula is fragrance-free, essential-oil-free, no drying alcohol, paraben-free, silicone-free and microplastic-free. Those claims come from the ingredient list itself, not from the packaging.

Where it fits in a routine

It can be used morning and evening. In a routine it goes after toner, before moisturiser. Apply to clean, dry skin and give it a minute to absorb before the next layer. Introduce one new treatment at a time so you can identify what is working.

This summary is generated from the product's ingredient list. It is not a review, it is not the brand's own marketing claims, and it does not replace advice from a dermatologist.

Pros and cons

Drawn purely from the ingredient list

Pros

  • No fragrance or declared allergens
  • No essential oils
  • No drying alcohol
  • Silicone-free
  • No microplastics
  • Strong humectant content for hydration
  • No common irritants flagged in the list
  • No recognised malassezia (fungal acne) triggers

Which skin types it suits

Scored on how rich or light the formula reads from its INCI order.

Suitable for

  • Balanced skin
  • Combination (oily) skin
  • Oily skin

Less suitable for

  • Dry skin
  • Combination (dry) skin

Sensitive skin

No ingredient in this formula carries a common-irritant flag, making it a reasonable option for reactive skin. A patch test is still recommended, as individual skin reactivity varies.

Skin concerns

Based on the curated benefits documented for this product's ingredients.

Helps with

  • Hydration 7 ingredients

    Attracts and locks in moisture to keep skin plump and dewy

  • Anti-Aging 3 ingredients

    Boosts collagen and cell turnover to reduce fine lines and wrinkles

  • Soothing 1 ingredient

    Calms redness, irritation, and inflammation for sensitive skin

Does not target

Anti-Acne Blackhead Reducing Dark Spot Fading Evens Skin Tone Oil Control Pore Minimizer Smooths Bumpy Skin

None of the ingredients in this formula are associated with these benefits. This is not unusual, as most products are designed to target a limited number of concerns.

Key ingredients

The actives, UV filters and benefit-carrying ingredients in this formula, in the order they are listed.

Water

1st on the list, which puts it at an estimated 30–80% of the formula.

Aqua (EU),Deionized Water,Distilled Water,Micromatrix Fractile AN,Onsen-Sui (JPN),Purified Water

Hydration
Glycerin

2nd on the list, which puts it at an estimated 5–20% of the formula.

Glycerine ;Glycerol (INN); Glycerol (RIFM); Glycerolum (EP); Glycyl Alcohol; 1,2,3-Propanetriol; 1,2,3-Trihydroxypropane

Hydration Anti-Aging
Tripeptide-29 Barrier peptides

3rd on the list, which puts it at an estimated 5–20% of the formula.

Tripeptide-29 is the synthetic peptide consisting of glycine, proline and hydroxyproline

Anti-Aging
Copper Tripeptide-1 Carrier peptides

4th on the list, which puts it at an estimated 2–10% of the formula.

Copper Tripeptide-1 is a copper complex of Tripeptide-1

Palmitoyl Tripeptide-1 Acetate Signal peptides

5th on the list, which puts it at an estimated 2–10% of the formula.

Palmitoyl Tripeptide-1 Acetate is the acetate salt of Palmitoyl Tripeptide-1

Sodium Hyaluronate Crosspolymer Hyaluronic acid

9th on the list, which puts it at an estimated 1–5% of the formula.

Hyaluronic acid, sodium salt, polymer with 1,1'-sulfonylbis[ethene]

Hydration Anti-Aging Soothing
Glycogen

10th on the list, which puts it at an estimated 1–5% of the formula.

Glycogen

Hydration
Propanediol

11th on the list, which puts it at an estimated 1–3% of the formula.

1,3-dihydroxypropane

Hydration
Pentylene Glycol

12th on the list, which puts it at an estimated 1–3% of the formula.

1,2-Dihydroxypentane

Hydration
Ethylhexylglycerin

18th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

1,2-Propanediol, 3-(2-ethylhexyloxy)

Hydration

Formula analysis

Each axis is scored from the ingredients present and how high up the list they sit.

Hydration High

Ingredients that pull and hold water in the upper layers of skin

Barrier support Moderate

Lipids and repair signals that support skin barrier integrity

Antioxidant support None

Ingredients that mop up free radicals from UV and pollution

Oil control None

Ingredients that moderate sebum or absorb shine

Brightening None

Ingredients that act on uneven tone and post-inflammatory marks

Soothing Low

Ingredients aimed at visible redness and reactivity

Cell renewal None

Retinoids, acids and enzymes that speed surface turnover

Firmness signalling High

Peptides and growth factors that signal for collagen support

Active and supporting ingredients

"Active" here means an ingredient carrying a recorded active type or a recognised UV filter.

Supporting ingredients (16)

Solvents, emollients, texture agents and preservatives — the formula that carries the actives.

Water Glycerin Myristoyl Nonapeptide-3 Tripeptide-2 Acetyl Tetrapeptide-2 Glycogen Propanediol Pentylene Glycol Dimethyl Isosorbide Ethoxydiglycol Isoceteth-20 Leuconostoc/radish Root Ferment Filtrate Caprylyl Glycol Ethylhexylglycerin Phenoxyethanol Chlorphenesin

What is and is not in it

Read from the full ingredient list. A brand's own claim may differ.

Free from

  • Fragrance-free
  • Essential-oil-free
  • No drying alcohol
  • Paraben-free
  • Silicone-free
  • Microplastic-free
  • Sulfate-free
  • Dye-free
  • Oil-free
  • No animal-derived ingredients

What to layer it with

Judged by the same curated rules our routine checker uses. It reads the ingredients, not the label.

Compatible with

  • Vitamin C (L-ascorbic acid)
  • Retinoids (retinol, retinal)
  • AHAs (glycolic, lactic)
  • BHA (salicylic acid)
  • PHAs (gluconolactone)
  • Azelaic acid
  • Copper peptides
  • Bakuchiol
  • Niacinamide
  • Hyaluronic acid
  • Ceramides
  • Signal peptides
  • Panthenol
  • Sunscreen

Use with caution

  • Benzoyl peroxide

    Best kept to separate routines — one in the morning, one at night, or on alternate days.

Where it fits in a routine

Morning Evening
  1. Cleanse
  2. Toning
  3. Treat
  4. Moisturise
  5. Protect

This product is the "Treat" step.

  • Apply to clean, dry skin and give it a minute to absorb before the next layer.
  • Introduce one new treatment at a time so you can identify what is working.

Safety and suitability

Flags to check, not verdicts. None of this is medical advice — if you are pregnant, breastfeeding or treating a skin condition, ask a doctor.

Pregnancy and breastfeeding
Nothing in this formula is on the standard pregnancy-caution list. That is not clearance — ask your doctor about anything you use daily.
Fungal acne (malassezia)
No ingredient here is a recognised food source for malassezia.
Sensitive and reactive skin
No ingredient in this formula carries a common-irritant flag, making it a reasonable option for reactive skin. A patch test is still recommended, as individual skin reactivity varies.

Ingredients by function

Most ingredients do more than one job, so these counts add up to more than the 20 ingredients on the label.

6
Peptide

Amino-acid chains that signal for repair or firmness

6
Solvent

Dissolves and carries everything else

4
Active

Changes how skin behaves rather than how it feels

4
Humectant

Draws water into the upper layers of skin

3
Preservative

Keeps the product free of microbial growth

3
Texture agent

Sets the thickness, spread and stability of the formula

1
Emollient

Softens and smooths by filling gaps between skin cells

1
Occlusive

Forms a film that slows water loss

1
Plant extract

Botanical material, usually for antioxidants or scent

1
Surfactant

Lifts oil and dirt, or holds oil and water together

Ingredient breakdown

Every ingredient on the label, in order, with what it does and roughly how much of it is likely to be there.

1 Water Solvent
Estimated level
30–80%
Confidence
Moderate — INCI order above the 1% line
Roles
Solvent

1st on the list, which puts it at an estimated 30–80% of the formula.

Aqua (EU),Deionized Water,Distilled Water,Micromatrix Fractile AN,Onsen-Sui (JPN),Purified Water

Hydration
3 scientific references
  • Skin Research and Technology, May 2015, pages 131-136
  • Skin Pharmacology and Applied Skin Physiology, November-December 1999, pages 344-351
  • Journal of Cosmetic Science, September-October 1993, pages 249-262
2 Glycerin Humectant
Estimated level
5–20%
Confidence
Moderate — INCI order above the 1% line
Roles
Humectant, Occlusive, Texture agent, Solvent

2nd on the list, which puts it at an estimated 5–20% of the formula.

Glycerine ;Glycerol (INN); Glycerol (RIFM); Glycerolum (EP); Glycyl Alcohol; 1,2,3-Propanetriol; 1,2,3-Trihydroxypropane

Hydration Anti-Aging
6 scientific references
  • Journal of Pharmaceutical Investigation, March 2021, pages 223-231
  • International Journal of Toxicology, November/December 2019, Volume 38, Supplement 3, pages 6S-22S
  • International Journal of Cosmetic Science, August 2016, ePublication
  • British Journal of Dermatology, July 2008, pages 23-34
  • Journal of Cosmetic Dermatology, June 2007, pages 75-82
  • Proceedings of the National Academy of Sciences, June 2003, pages 7, 360-7, 365
3 Tripeptide-29 Active
Estimated level
5–20%
Confidence
Moderate — INCI order above the 1% line
Roles
Active, Peptide

3rd on the list, which puts it at an estimated 5–20% of the formula.

Tripeptide-29 is the synthetic peptide consisting of glycine, proline and hydroxyproline

Anti-Aging
3 scientific references
  • Amino Acids, January 2018, pages 29-38
  • Journal of Cosmetic Dermatology, December 2016, pages 514-519
  • Journal of the Society of Cosmetic Scientists of Korea, 2010, pages 65-69
4 Copper Tripeptide-1 Active
Estimated level
2–10%
Confidence
Moderate — INCI order above the 1% line
Roles
Active, Peptide

4th on the list, which puts it at an estimated 2–10% of the formula.

Copper Tripeptide-1 is a copper complex of Tripeptide-1

5 Palmitoyl Tripeptide-1 Acetate Active
Estimated level
2–10%
Confidence
Moderate — INCI order above the 1% line
Roles
Active, Peptide

5th on the list, which puts it at an estimated 2–10% of the formula.

Palmitoyl Tripeptide-1 Acetate is the acetate salt of Palmitoyl Tripeptide-1

6 Myristoyl Nonapeptide-3 Peptide
Estimated level
2–10%
Confidence
Moderate — INCI order above the 1% line
Roles
Peptide

6th on the list, which puts it at an estimated 2–10% of the formula.

Myristoyl Nonapeptide-3 is the product of the reaction of myristic acid and Nonapeptide-3

7 Tripeptide-2 Peptide
Estimated level
1–5%
Confidence
Moderate — INCI order above the 1% line
Roles
Peptide

7th on the list, which puts it at an estimated 1–5% of the formula.

Tripeptide-2 is a synthetic peptide containing tryrosine and valine residues

8 Acetyl Tetrapeptide-2 Peptide
Estimated level
1–5%
Confidence
Moderate — INCI order above the 1% line
Roles
Peptide

8th on the list, which puts it at an estimated 1–5% of the formula.

Acetyl Tetrapeptide-2 is product obtained by the acetylation of Tetrapeptide-2

9 Sodium Hyaluronate Crosspolymer Humectant
Estimated level
1–5%
Confidence
Moderate — INCI order above the 1% line
Roles
Humectant, Active

9th on the list, which puts it at an estimated 1–5% of the formula.

Hyaluronic acid, sodium salt, polymer with 1,1'-sulfonylbis[ethene]

Hydration Anti-Aging Soothing
10 Glycogen Humectant
Estimated level
1–5%
Confidence
Moderate — INCI order above the 1% line
Roles
Humectant

10th on the list, which puts it at an estimated 1–5% of the formula.

Glycogen

Hydration
11 Propanediol Texture agent
Estimated level
1–3%
Confidence
Moderate — INCI order above the 1% line
Roles
Texture agent, Solvent

11th on the list, which puts it at an estimated 1–3% of the formula.

1,3-dihydroxypropane

Hydration
4 scientific references
  • PubChem Compound Summary, April 2021, ePublication
  • SpecialChem, Accessed April 2021, ePublication
  • Cosmetic Ingredient Review, June 2018, pages 1-73
  • Cosmetics & Toiletries, May 2013, pages 81-86
12 Pentylene Glycol Solvent
Estimated level
1–3%
Confidence
Moderate — INCI order above the 1% line
Roles
Solvent

12th on the list, which puts it at an estimated 1–3% of the formula.

1,2-Dihydroxypentane

Hydration
4 scientific references
  • https://thedermreviewcom/pentylene-glycol/
  • Regulatory Toxicology and Pharmacology, July 2017, pages 106-111
  • Prospector, June 2015, ePublication
  • International Journal of Toxicology, October 2012, pages 147S-168S
13 Dimethyl Isosorbide Texture agent
Estimated level
1–3%
Confidence
Moderate — INCI order above the 1% line
Roles
Texture agent, Solvent

13th on the list, which puts it at an estimated 1–3% of the formula.

1,4:3,6-Dianhydro-2,5-di-O-methyl-D-glucitol

14 Ethoxydiglycol Humectant
Estimated level
1–3%
Confidence
Moderate — INCI order above the 1% line
Roles
Humectant, Solvent

14th on the list, which puts it at an estimated 1–3% of the formula.

2-(2-Ethoxyethoxy)ethanol; Carbitol; Diethylene glycol monoethyl ether; DEGEE

15 Isoceteth-20 Surfactant
Estimated level
1–3%
Confidence
Moderate — INCI order above the 1% line
Roles
Surfactant

15th on the list, which puts it at an estimated 1–3% of the formula.

Alcohols, C16-branched, ethoxylated (20 mol EO average molar ratio)

16 Leuconostoc/radish Root Ferment Filtrate Plant extract
Estimated level
1–3%
Confidence
Moderate — INCI order above the 1% line
Roles
Plant extract, Preservative

16th on the list, which puts it at an estimated 1–3% of the formula.

Leuconostoc/Radish Root Ferment Filtrate is a filtrate of the product obtained by the fermentation of Raphanus sativus roots by the microorganism, Leuconostoc

17 Caprylyl Glycol Emollient
Estimated level
1–3%
Confidence
Moderate — INCI order above the 1% line
Roles
Emollient

17th on the list, which puts it at an estimated 1–3% of the formula.

Octane-1,2-diol

18 Ethylhexylglycerin
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

18th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

1,2-Propanediol, 3-(2-ethylhexyloxy)

Hydration
5 scientific references
  • PLoS One, October 2016, ePublication
  • Contact Dermatitis, May 2016, pages 281-288
  • International Journal of Toxicology, September 2013, pages 5S-21S
  • Personal Care, 2008, pages 1-4
  • Cosmetic Science Technology, 2006, pages 1-11
19 Phenoxyethanol Preservative
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Preservative

19th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

2-Phenoxyethanol

20 Chlorphenesin Preservative
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Preservative

20th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

1,2-Propanediol, 3-(4-chlorophenoxy)-

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Frequently asked questions

What ingredients are in Copper Amino Isolate Serum 3 1:1?

WATER, GLYCERIN, TRIPEPTIDE-29, COPPER TRIPEPTIDE-1, PALMITOYL TRIPEPTIDE-1 ACETATE, MYRISTOYL NONAPEPTIDE-3, TRIPEPTIDE-2, ACETYL TETRAPEPTIDE-2, SODIUM HYALURONATE CROSSPOLYMER, GLYCOGEN, PROPANEDIOL, PENTYLENE GLYCOL, DIMETHYL ISOSORBIDE, ETHOXYDIGLYCOL, ISOCETETH-20, LEUCONOSTOC/RADISH ROOT FERMENT FILTRATE, CAPRYLYL GLYCOL, ETHYLHEXYLGLYCERIN, PHENOXYETHANOL, CHLORPHENESIN.

What are the active ingredients in Copper Amino Isolate Serum 3 1:1?

TRIPEPTIDE-29, COPPER TRIPEPTIDE-1, PALMITOYL TRIPEPTIDE-1 ACETATE, SODIUM HYALURONATE CROSSPOLYMER.

How do I use Copper Amino Isolate Serum 3 1:1?

Apply it after toner, before moisturiser. Apply to clean, dry skin and give it a minute to absorb before the next layer. Introduce one new treatment at a time so you can identify what is working.

What skin types is Copper Amino Isolate Serum 3 1:1 good for?

Judged on how rich the formula reads from its ingredient list, it suits Balanced, Combination (oily), Oily skin best. It is the least natural fit for Dry, Combination (dry) skin.

Is Copper Amino Isolate Serum 3 1:1 good for sensitive skin?

No ingredient in this formula carries a common-irritant flag, making it a reasonable option for reactive skin. A patch test is still recommended, as individual skin reactivity varies.

Is Copper Amino Isolate Serum 3 1:1 fungal acne safe?

No ingredient in this formula is a recognised food source for malassezia, the yeast behind fungal acne.

Can I use Copper Amino Isolate Serum 3 1:1 while pregnant?

Nothing in this formula is on the standard pregnancy-caution list. That is not medical clearance — check anything you use daily with your doctor or midwife.

Is Copper Amino Isolate Serum 3 1:1 fragrance free?

Yes. Reading the full ingredient list, this formula is fragrance-free.

Does Copper Amino Isolate Serum 3 1:1 contain alcohol?

No. Reading the full ingredient list, this formula is no drying alcohol.

Is Copper Amino Isolate Serum 3 1:1 silicone free?

Yes. Reading the full ingredient list, this formula is silicone-free.

Does Copper Amino Isolate Serum 3 1:1 contain essential oils?

No. Reading the full ingredient list, this formula is essential-oil-free.

Is Copper Amino Isolate Serum 3 1:1 paraben free?

Yes. Reading the full ingredient list, this formula is paraben-free.

What can I layer with Copper Amino Isolate Serum 3 1:1?

It layers well with Vitamin C (L-ascorbic acid), Retinoids (retinol, retinal), AHAs (glycolic, lactic), BHA (salicylic acid), PHAs (gluconolactone), Azelaic acid. Take more care combining it with Benzoyl peroxide — use them in separate routines or on alternate days.

When should I apply Copper Amino Isolate Serum 3 1:1?

Use it morning and evening, after toner, before moisturiser.

How many ingredients does Copper Amino Isolate Serum 3 1:1 have?

It lists 20 ingredients, of which 4 are recorded as actives.

Who makes Copper Amino Isolate Serum 3 1:1?

NIOD.

Brand
NIOD

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