Dr.Althea 345 Relief Serum

Dr.Althea

345 Relief Serum

face serum

Added Last edited

Fit by skin type

General, ingredient-based — not your personalized match.

Dry
49%
Combination (dry)
49%
Balanced
79%
Combination (oily)
91%
Oily
91%

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50
Ingredients
5
Benefits
4
Actives
Find Dupes

Discover the Dr.Althea 345 Relief Serum, a lightweight hydrating serum that helps soothe stressed, dehydrated skin while leaving it soft and refreshed. Made to slot right into the beloved 345 routine, the serum layers beautifully before the viral 345 Relief Cream for an extra boost of calming hydration.

Key Insights

Benefits

5
Anti-Aging
Dark Spot Fading
Hydration
Pore Minimizer
Soothing

Active Ingredients

4
Ceramides Hyaluronic acid Vitamin B3 (niacinamide) Vitamin B5 (panthenol)

Risks

1
Synthetic polymer

About 345 Relief Serum

Overview

345 Relief Serum is a watery-light serum from Dr.Althea. The formula is built mainly around hydration. The ingredient list runs to 50 ingredients, each broken down in full below.

Texture and finish

By its ingredient list the formula reads as very light — essentially a water-and-humectant base with little emollient weight. With almost no emollient load it should absorb quickly and finish close to matte. Hydration is handled by Propanediol, Butylene Glycol and Glycerin, humectants that pull water into the upper layers of skin rather than sealing it there.

What the formula does

Hydration: High. Ingredients that pull and hold water in the upper layers of skin, and here that comes from Propanediol, Butylene Glycol, Glycerin and Panthenol.

Soothing: Moderate. Ingredients aimed at visible redness and reactivity, and here that comes from Panthenol, Madecassoside, Asiaticoside and Beta-glucan.

Barrier support: Moderate. Lipids and repair signals that support skin barrier integrity, and here that comes from Niacinamide, Panthenol, Hydrogenated Lecithin and Madecassoside.

Who it suits

On richness alone it suits Combination (oily) and Oily skin best, and is the least natural fit for Dry and Combination (dry) skin. Nothing in the list is flagged as a common irritant, which is a reasonable starting point for reactive skin — though a patch test is still the only way to know.

What it does not target

The formula contributes little or nothing on cell renewal and firmness signalling. That is not a fault — most products are not meant to do everything — but if one of those is your priority, this is not the product that will address it.

What is not in it

Reading the full list, the formula is fragrance-free, essential-oil-free, no drying alcohol, paraben-free, silicone-free and microplastic-free. Those claims come from the ingredient list itself, not from the packaging.

Where it fits in a routine

It can be used morning and evening. In a routine it goes after toner, before moisturiser. Apply to clean, dry skin and give it a minute to absorb before the next layer. Introduce one new treatment at a time so you can identify what is working.

This summary is generated from the product's ingredient list. It is not a review, it is not the brand's own marketing claims, and it does not replace advice from a dermatologist.

Pros and cons

Drawn purely from the ingredient list

Pros

  • No fragrance or declared allergens
  • No essential oils
  • No drying alcohol
  • Silicone-free
  • No microplastics
  • Strong humectant content for hydration
  • No common irritants flagged in the list

Things to know

  • 2 ingredients could feed malassezia (fungal acne)

Which skin types it suits

Scored on how rich or light the formula reads from its INCI order.

Suitable for

  • Combination (oily) skin
  • Oily skin

May suit

  • Balanced skin

Less suitable for

  • Dry skin
  • Combination (dry) skin

Sensitive skin

No ingredient in this formula carries a common-irritant flag, making it a reasonable option for reactive skin. A patch test is still recommended, as individual skin reactivity varies.

Skin concerns

Based on the curated benefits documented for this product's ingredients.

Helps with

  • Hydration 23 ingredients

    Attracts and locks in moisture to keep skin plump and dewy

  • Anti-Aging 16 ingredients

    Boosts collagen and cell turnover to reduce fine lines and wrinkles

  • Soothing 12 ingredients

    Calms redness, irritation, and inflammation for sensitive skin

  • Dark Spot Fading 1 ingredient

    Fades hyperpigmentation and evens out dark spots over time

  • Pore Minimizer 1 ingredient

    Tightens and refines the look of enlarged pores

Does not target

Anti-Acne Blackhead Reducing Evens Skin Tone Oil Control Smooths Bumpy Skin

None of the ingredients in this formula are associated with these benefits. This is not unusual, as most products are designed to target a limited number of concerns.

Key ingredients

The actives, UV filters and benefit-carrying ingredients in this formula, in the order they are listed.

1st on the list, which puts it at an estimated 30–80% of the formula.

Aqua (EU),Deionized Water,Distilled Water,Micromatrix Fractile AN,Onsen-Sui (JPN),Purified Water

Hydration

3rd on the list, which puts it at an estimated 5–20% of the formula.

1,3-dihydroxypropane

Hydration

6th on the list, which puts it at an estimated 2–10% of the formula.

Butane-1,3-diol (CAS No. 107-88-0/ EC No. 203-529-7) (R)-(-)-butane-1,3-diol” (CAS No. 6290-03-5/ EC No. 228-532-0)

Hydration

7th on the list, which puts it at an estimated 1–5% of the formula.

Glycerine ;Glycerol (INN); Glycerol (RIFM); Glycerolum (EP); Glycyl Alcohol; 1,2,3-Propanetriol; 1,2,3-Trihydroxypropane

Hydration Anti-Aging
Niacinamide Vitamin B3 (niacinamide)

8th on the list, which puts it at an estimated 1–5% of the formula.

Niacinamide (vitamin B3) is a gentle skincare active that repairs the skin barrier, calms redness, controls oil and evens tone at 2–5%. Official IUPAC name: **3-Pyridinecarboxamide**

Soothing Anti-Aging Pore Minimizer
Panthenol Vitamin B5 (panthenol)

9th on the list, which puts it at an estimated 1–5% of the formula.

Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (2R)-; dl-Panthenol

Hydration Soothing

11th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Decanoic acid, ester with 1,2,3-propanetriol octanoate; Glycerides, mixed decanoyl and octanoyl

Hydration

12th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

1-Decene, homopolymer, hydrogenated

Hydration

14th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Ethanone, 1-(4-hydroxyphenyl)-,p-Hydroxyacetophenone

Anti-Aging Hydration

18th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Octanoic acid, monoester with glycerol

Hydration

19th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

1,2-Propanediol, 3-(2-ethylhexyloxy)

Hydration

21st on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

1,2-Dihydroxypentane

Hydration

Formula analysis

Each axis is scored from the ingredients present and how high up the list they sit.

Hydration High

Ingredients that pull and hold water in the upper layers of skin

Barrier support Moderate

Lipids and repair signals that support skin barrier integrity

Antioxidant support Low

Ingredients that mop up free radicals from UV and pollution

Oil control Low

Ingredients that moderate sebum or absorb shine

Brightening Low

Ingredients that act on uneven tone and post-inflammatory marks

Soothing Moderate

Ingredients aimed at visible redness and reactivity

Cell renewal None

Retinoids, acids and enzymes that speed surface turnover

Firmness signalling None

Peptides and growth factors that signal for collagen support

Active and supporting ingredients

"Active" here means an ingredient carrying a recorded active type or a recognised UV filter.

Active ingredients (8)

Supporting ingredients (42)

Solvents, emollients, texture agents and preservatives — the formula that carries the actives.

Water Betula Platyphylla Japonica Juice Propanediol Melaleuca Alternifolia Leaf Water Dipropylene Glycol Butylene Glycol Glycerin 1,2-hexanediol Caprylic/capric Triglyceride Hydrogenated Polydecene C14-22 Alcohols Hydroxyacetophenone Acrylates/c10-30 Alkyl Acrylate Crosspolymer C12-20 Alkyl Glucoside Tromethamine Glyceryl Caprylate Ethylhexylglycerin Xanthan Gum Pentylene Glycol Disodium Edta Caprylyl Glycol Camellia Sinensis Leaf Water Poloxamer 407 Hydrogenated Lecithin Madecassoside Polyglutamic Acid Decyl Glucoside Asiaticoside Beta-glucan Asiatic Acid Madecassic Acid Sodium Phytate Sodium DNA Aluminum/magnesium Hydroxide Stearate Centella Asiatica Extract Cholesterol Lysolecithin Phosphatidylcholine Xylose Hydroxypropyl Cyclodextrin Tannic Acid Resveratrol

What is and is not in it

Read from the full ingredient list. A brand's own claim may differ.

Free from

  • Fragrance-free
  • Essential-oil-free
  • No drying alcohol
  • Paraben-free
  • Silicone-free
  • Microplastic-free
  • Sulfate-free
  • Dye-free
  • Oil-free
  • No animal-derived ingredients

What to layer it with

Judged by the same curated rules our routine checker uses. It reads the ingredients, not the label.

Compatible with

  • Vitamin C (L-ascorbic acid)
  • Retinoids (retinol, retinal)
  • AHAs (glycolic, lactic)
  • BHA (salicylic acid)
  • PHAs (gluconolactone)
  • Benzoyl peroxide
  • Azelaic acid
  • Copper peptides
  • Bakuchiol
  • Niacinamide
  • Hyaluronic acid
  • Ceramides
  • Signal peptides
  • Panthenol
  • Sunscreen

Nothing in this formula belongs to a group our rules can put in conflict, so it layers freely. Order still matters — thinnest texture first.

Where it fits in a routine

Morning Evening
  1. Cleanse
  2. Toning
  3. Treat
  4. Moisturise
  5. Protect

This product is the "Treat" step.

  • Apply to clean, dry skin and give it a minute to absorb before the next layer.
  • Introduce one new treatment at a time so you can identify what is working.

Safety and suitability

Flags to check, not verdicts. None of this is medical advice — if you are pregnant, breastfeeding or treating a skin condition, ask a doctor.

Pregnancy and breastfeeding
Nothing in this formula is on the standard pregnancy-caution list. That is not clearance — ask your doctor about anything you use daily.
Fungal acne (malassezia)
2 ingredients could feed malassezia: Glyceryl Caprylate, Aluminum/magnesium Hydroxide Stearate. That is about the yeast's food supply, not a prediction that you will break out.
Sensitive and reactive skin
No ingredient in this formula carries a common-irritant flag, making it a reasonable option for reactive skin. A patch test is still recommended, as individual skin reactivity varies.
Recorded ingredient risks
Synthetic polymer

Ingredients by function

Most ingredients do more than one job, so these counts add up to more than the 50 ingredients on the label.

11
Texture agent

Sets the thickness, spread and stability of the formula

10
Surfactant

Lifts oil and dirt, or holds oil and water together

8
Active

Changes how skin behaves rather than how it feels

8
Solvent

Dissolves and carries everything else

7
Humectant

Draws water into the upper layers of skin

4
Antioxidant

Neutralises free radicals from UV and pollution

4
Emollient

Softens and smooths by filling gaps between skin cells

4
Plant extract

Botanical material, usually for antioxidants or scent

3
Occlusive

Forms a film that slows water loss

2
Chelator

Binds trace metals that would otherwise spoil the formula

1
Soothing

Calms visible redness and irritation

1
pH adjuster

Sets the acidity the formula needs to work

1
Preservative

Keeps the product free of microbial growth

Ingredient breakdown

Every ingredient on the label, in order, with what it does and roughly how much of it is likely to be there.

1 Water Solvent
Estimated level
30–80%
Confidence
Moderate — INCI order above the 1% line
Roles
Solvent

1st on the list, which puts it at an estimated 30–80% of the formula.

Aqua (EU),Deionized Water,Distilled Water,Micromatrix Fractile AN,Onsen-Sui (JPN),Purified Water

Hydration
3 scientific references
  • Skin Research and Technology, May 2015, pages 131-136
  • Skin Pharmacology and Applied Skin Physiology, November-December 1999, pages 344-351
  • Journal of Cosmetic Science, September-October 1993, pages 249-262
Estimated level
5–20%
Confidence
Moderate — INCI order above the 1% line
Roles
Plant extract

2nd on the list, which puts it at an estimated 5–20% of the formula.

Betula Platyphylla Japonica Juice is the sap from the tree, Betula platyphylla japonica, Betulaceae

3 Propanediol Texture agent
Estimated level
5–20%
Confidence
Moderate — INCI order above the 1% line
Roles
Texture agent, Solvent

3rd on the list, which puts it at an estimated 5–20% of the formula.

1,3-dihydroxypropane

Hydration
4 scientific references
  • PubChem Compound Summary, April 2021, ePublication
  • SpecialChem, Accessed April 2021, ePublication
  • Cosmetic Ingredient Review, June 2018, pages 1-73
  • Cosmetics & Toiletries, May 2013, pages 81-86
Estimated level
2–10%
Confidence
Moderate — INCI order above the 1% line
Roles
Plant extract, Preservative

4th on the list, which puts it at an estimated 2–10% of the formula.

Melaleuca Alternifolia Leaf Water is an aqueous solution of the steam distillates obtained from the leaves of the Tea Tree, Melaleuca alternifolia, Myrtaceae

5 Dipropylene Glycol Texture agent
Estimated level
2–10%
Confidence
Moderate — INCI order above the 1% line
Roles
Texture agent, Solvent

5th on the list, which puts it at an estimated 2–10% of the formula.

1,1'-Oxydipropan-2-ol; Oxydipropan-2-ol; Hydroxypropyloxypropanol

6 Butylene Glycol Humectant
Estimated level
2–10%
Confidence
Moderate — INCI order above the 1% line
Roles
Humectant, Texture agent, Solvent

6th on the list, which puts it at an estimated 2–10% of the formula.

Butane-1,3-diol (CAS No. 107-88-0/ EC No. 203-529-7) (R)-(-)-butane-1,3-diol” (CAS No. 6290-03-5/ EC No. 228-532-0)

Hydration
5 scientific references
  • CosmeticsInfoorg, Accessed March 2021, ePublication
  • US Food and Drug Administration Code of Federal Regulations</em>, Accessed March 2021, ePublication
  • International Journal of Toxicology, May 2011, pages 5S-16S
  • Skin Research and Technology, November 2007, pages 417-24
  • Journal of the American College of Toxicology, September 1985, pages 223-248
7 Glycerin Humectant
Estimated level
1–5%
Confidence
Moderate — INCI order above the 1% line
Roles
Humectant, Occlusive, Texture agent, Solvent

7th on the list, which puts it at an estimated 1–5% of the formula.

Glycerine ;Glycerol (INN); Glycerol (RIFM); Glycerolum (EP); Glycyl Alcohol; 1,2,3-Propanetriol; 1,2,3-Trihydroxypropane

Hydration Anti-Aging
6 scientific references
  • Journal of Pharmaceutical Investigation, March 2021, pages 223-231
  • International Journal of Toxicology, November/December 2019, Volume 38, Supplement 3, pages 6S-22S
  • International Journal of Cosmetic Science, August 2016, ePublication
  • British Journal of Dermatology, July 2008, pages 23-34
  • Journal of Cosmetic Dermatology, June 2007, pages 75-82
  • Proceedings of the National Academy of Sciences, June 2003, pages 7, 360-7, 365
8 Niacinamide Active
Estimated level
1–5%
Confidence
Moderate — INCI order above the 1% line
Roles
Active

8th on the list, which puts it at an estimated 1–5% of the formula.

Niacinamide (vitamin B3) is a gentle skincare active that repairs the skin barrier, calms redness, controls oil and evens tone at 2–5%. Official IUPAC name: **3-Pyridinecarboxamide**

Soothing Anti-Aging Pore Minimizer
15 scientific references
  • International Journal of Dermatology, February 2021, pages 166-173
  • Biomolecules & Therapeutics, July 2019, pages 562-569
  • Experimental Dermatology, February 2019, pages 15-22
  • Dermatologic Therapy, September 2017, ePublication
  • Journal of Investigative Dermatology, May 2017, page S116
  • International Journal of Pharmaceutics, March 2017, pages 158-162
  • Facial Plastic Surgery Clinics of North America, May 2016, pages 145-152
  • Clinical, Cosmetic, and Investigational Dermatology, July 2015, pages 405-412
  • Skin Pharmacology and Physiology, June 2014, pages 311-315
  • International Journal of Pharmacy, January 2013, pages 192-201
  • Dermatoendrocrinology, July 2012, pages 308-319
  • International Journal of Toxicology, September 2005, pages 1-31
  • Dermatologic Surgery, July 2005, pages 860-865
  • International Journal of Cosmetic Science, October 2004, pages 231-238
  • Journal of Cosmetic Dermatology, April 2004, pages 88-93
9 Panthenol Active
Estimated level
1–5%
Confidence
Moderate — INCI order above the 1% line
Roles
Active

9th on the list, which puts it at an estimated 1–5% of the formula.

Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (2R)-; dl-Panthenol

Hydration Soothing
7 scientific references
  • The Linus Pauling Institute, Oregon State University, Accessed April 2021, ePublication
  • International Journal of Cosmetic Science, December 2019, pages 534-547
  • Journal of Cosmetic Dermatology, January 2019, pages 346-354
  • Cosmetic Ingredient Review, March 2018, pages 1-51
  • The Journal of Dermatological Treatment, August 2017, pages 173-180
  • Journal of Cosmetic Science, August 2011, pages 361-370
  • American Journal of Clinical Dermatology, Volume 3, 2002, pages 427-433
10 1,2-hexanediol Solvent
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Solvent

10th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

11th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Decanoic acid, ester with 1,2,3-propanetriol octanoate; Glycerides, mixed decanoyl and octanoyl

Hydration
5 scientific references
  • International Journal of Toxicology, September 2020, pages 34-35
  • Periodica Polytechnica Chemical Engineering, 2014, pages 43-48
  • International Journal of Toxicology, January 2003, pages 4-5
  • Food and Chemical Toxicology, January 2000, pages 79-98
  • Journal of the Society of Cosmetic Chemists, August 1985, pages 303-311
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Emollient, Solvent

12th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

1-Decene, homopolymer, hydrogenated

Hydration
13 C14-22 Alcohols Texture agent
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Texture agent

13th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

C14-22 Alcohols is a mixture of synthetic fatty alcohols with 14 to 22 carbons in the alkyl chain

14 Hydroxyacetophenone Antioxidant
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Antioxidant

14th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Ethanone, 1-(4-hydroxyphenyl)-,p-Hydroxyacetophenone

Anti-Aging Hydration
4 scientific references
  • Journal of Oleo Science, February 2019, pages 183-191
  • Applied Environmental Microbiology, June 2018, ePublication
  • Journal of Biosciences, May-June 2004, pages 345-353
  • Scientific Reports, April 2021, pages 1–7
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Occlusive, Texture agent

15th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

C10-30 alkyl propenoate, polymer with propenoic acid, butenoic acidand/or alkyl propenoates, product with propenyl sucrose ether or propenyl 2,2-dihydroxymethyl-1,3-propanediol

Synthetic polymer
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Surfactant

16th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

C12-20 Alkyl Glucoside is the product obtained by the condensation of C12-20 alcohols with glucose

17 Tromethamine pH adjuster
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
pH adjuster

17th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

1,3-Propanediol, 2-amino-2-(hydroxymethyl)-

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Emollient, Surfactant

18th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Octanoic acid, monoester with glycerol

Hydration
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

19th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

1,2-Propanediol, 3-(2-ethylhexyloxy)

Hydration
5 scientific references
  • PLoS One, October 2016, ePublication
  • Contact Dermatitis, May 2016, pages 281-288
  • International Journal of Toxicology, September 2013, pages 5S-21S
  • Personal Care, 2008, pages 1-4
  • Cosmetic Science Technology, 2006, pages 1-11
20 Xanthan Gum Surfactant
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Surfactant, Texture agent

20th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Xanthan gum

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Solvent

21st on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

1,2-Dihydroxypentane

Hydration
4 scientific references
  • https://thedermreviewcom/pentylene-glycol/
  • Regulatory Toxicology and Pharmacology, July 2017, pages 106-111
  • Prospector, June 2015, ePublication
  • International Journal of Toxicology, October 2012, pages 147S-168S
22 Disodium Edta Texture agent
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Texture agent, Chelator

22nd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Disodium dihydrogen ethylenediaminetetraacetate

23 Caprylyl Glycol Emollient
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Emollient

23rd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Octane-1,2-diol

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Plant extract

24th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Camellia Sinensis Leaf Water is an aqueous solution of the odoriferous principles of the leaves of the Tea, Camellia sinensis, Theaceae

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Humectant, Active

25th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Hydrolyzed Hyaluronic Acid is the hydrolysate of Hyaluronic Acid derived by acid, enzyme or other method of hydrolysis

Hydration
26 Hyaluronic Acid Humectant
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Humectant, Active

26th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Hyaluronic acid

Anti-Aging Hydration
5 scientific references
  • Journal of Evidence-Based, Complementary and Alternative Medicine, October 2017, pages 816-823
  • Journal of Medicinal Food, October 2016, pages 1, 172-1, 179
  • Nutrition Journal, July 2013, ePublication
  • Journal of Drugs in Dermatology, 2011, issue 9, pages 990-1000
  • Journal of Clinical and Aesthetic Dermatology, March 2009, pages 38-43
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Humectant, Active

27th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Hyaluronic acid, sodium, salt

Hydration Anti-Aging Soothing
5 scientific references
  • Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und Verwandte Gebiete, December 2017, pages 987-993
  • Journal of Cosmetic Dermatology, July 2014, pages 277-287
  • Journal of Clinical and Aesthetic Dermatology, October 2012, pages 20-23
  • DermatoEndocrinology, July-December 2012, pages 253-258
  • Journal of Drugs in Dermatology, September 2011, pages 990-1000
28 Poloxamer 407 Surfactant
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Surfactant

28th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Oxirane, methyl-, polymer with oxirane (98;67)

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Humectant, Active

29th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Hyaluronic acid, sodium salt, polymer with 1,1'-sulfonylbis[ethene]

Hydration Anti-Aging Soothing
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Surfactant

30th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Lecithins, hydrogenated

Hydration
4 scientific references
  • International Journal of Toxicology, September 2020, pages 5S-25S
  • Nanocosmetics, June 2019, pages 95–140
  • Current Drug Delivery, 2016, pages 111–120
  • Pharmaceutical Research, February 2013, pages 538–55
31 Madecassoside Antioxidant
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Antioxidant

31st on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

O-6-Deoxy-α-L-mannopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl (2α,3β,4α,6β)-2,3,6,23-tetrahydroxyurs-12-en-28-oate

Anti-Aging Soothing
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Active

32nd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Propanoic acid, 3-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino-, (R)-

Hydration Soothing
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

33rd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Polymer of glutamic acid

Hydration Anti-Aging
5 scientific references
  • Biomass Conversion and Biorefinery, March 2021, ePublication
  • Molecules, July 2020, pages 1–33
  • Journal of Materials Science, Materials in Medicine, Volume 31, May 2020, ePublication
  • Journal of Biomedical Materials Research, November 2017, pages
  • Saudi Journal of Biological Sciences, April 2014, pages 153–158
34 Decyl Glucoside Surfactant
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Surfactant, Texture agent

34th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

D-Glucoside, Decyl

35 Asiaticoside Antioxidant
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Antioxidant

35th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Urs-12-en-28-oic acid, 2,3,23-trihydroxy-, O-6-deoxy-alpha-L-mannopyranosyl-(1->4)-O-beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranosyl ester (2alpha, 3beta, 4alpha)-

Anti-Aging Soothing
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

36th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

beta-Glucan is a polysaccharide consisting of b(1-3) linked glucose chains carrying b(1-6) linked glucose sidechains

Soothing Hydration
6 scientific references
  • Journal of Cosmetic Dermatology, December 2018, pages 1, 101-1, 107
  • International Journal of Molecular Sciences, September 2017, pages 1-48
  • Phytotherapy Research, February 2014, pages 159-166
  • Cosmetic Ingredient Review, October 2012, pages 1-52
  • Journal of Drugs in Dermatology, February 2007, pages 167-170
  • International Journal of Cosmetic Science, October 2005, page 292
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

37th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

(2.alpha.,3.beta.,4.alpha.)-2,3,23-Trihydroxyurs-12-en-28-oic acid

Anti-Aging
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

38th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Urs-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-, (2alpha,3beta,4alpha,6beta)-

Anti-Aging Soothing
39 Sodium Phytate Chelator
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Chelator

39th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Myo-Inositol, hexakis(dihydrogen phosphate), sodium salt

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

40th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Deoxyribonucleic acid, sodium salts

41 Ceramide NP Active
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Active

41st on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Ceramide NP,1,3,4-Octadecanetriol, 2-Octadecanamide,Stearoyl-C18-Phytosphingosine,Stearoyl-4-Hydroxysphinganine

Hydration Anti-Aging
11 scientific references
  • International Journal of Toxicology, 2020, pages 5S-25S
  • International Journal of Molecular Sciences, August 2019, pages 1-15
  • Skin Pharmacology and Physiology, 2016, pages 135-147
  • Biochimica et Biophysica Acta, October 2014, pages 2473-2483
  • Journal of the American Academy of Dermatology, July 2014, pages 177-184
  • Journal of Lipid Research, July 2008, pages 1, 466-1, 476
  • Journal of Lipid Research, September 2007, pages 1936-1943
  • American Journal of Clinical Dermatology, 2003, pages 107-129
  • Contact Dermatitis, June 2002, pages 331-338
  • Journal of Investigative Dermatology, November 2001, pages 1, 126-1, 136
  • Skin Pharmacology and Applied Skin Physiology, September-October 2001, pages 261-271
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Texture agent

42nd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Aluminum magnesium hydroxide and stearic acid

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Soothing, Surfactant, Plant extract

43rd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Centella Asiatica Extract is the extract of the whole plant Hydrocotyl, Centella asiatica L., Apiaceae

Soothing Anti-Aging
6 scientific references
  • Phytomedicine, April 2018, pages 110–119
  • Clinical, Cosmetic, and Investigational Dermatology, August 2017, pages 311–315
  • Indian Journal of Pharmaceutical Sciences, Jan-Feb 2016, pages 27–33
  • Postepy Dermatologii I, February 2013, pages 46–49
  • Indian Journal of Pharmaceutical Sciences, 2010, pages 546–556
  • Scientific Reports, June 2021, ePublication
44 Cholesterol Emollient
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Emollient, Surfactant, Texture agent

44th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Cholest-5-en-3-ol (beta)-

Hydration Anti-Aging
4 scientific references
  • Frontiers in Bioengineering and Biotechnology, August 2015, pages 1-6
  • Journal of Cosmetic Dermatology, July 2007, pages 239-242
  • Journal of Structural Biology, June 2007, pages 386-400
  • International Journal of Toxicology, 2006, pages 1-89
45 Lysolecithin Surfactant
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Surfactant

45th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Lecithins, hydrolyzed

46 Phosphatidylcholine Surfactant
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Surfactant

46th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Lecithins, egg yolk

Hydration
47 Xylose Humectant
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Humectant

47th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

D-Xylose

Hydration Soothing
8 scientific references
  • Supercharged Hydration
  • How Hyaluronic Acid Benefits Skin
  • What is Dehydrated Skin & How to Choose the Best Products
  • What Your Moisturizer Must Contain
  • Moisturizer Myths You Should Stop Believing Now
  • The Benefits of Glycerin in Skin Care
  • The Best Face Oils for Skin
  • How Facial Oils Help Skin
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

48th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

.beta.-Cyclodextrin, 2-hydroxypropyl ethers

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

49th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Tannins. Gallic acid derivatives found in nutgalls, bark and other plant parts, especially oak bark

Anti-Aging
50 Resveratrol Occlusive
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Occlusive, Antioxidant

50th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

1,3-Benzenediol, 5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-

Anti-Aging Dark Spot Fading Soothing
8 scientific references
  • Biomedicine and Pharmacotherapy, November 2021, ePublication
  • International Journal of Molecular Sciences, October 2021, pages 1–26
  • Phytotherapy Research, March 2020, pages 435–447
  • Biomolecules and Therapeutics, October 2018, pages 1–14
  • Journal of Cosmetic and Laser Therapy, May 2018 ePublication
  • Journal of Drugs in Dermatology, December 2013, pages 1389-1394
  • Archives of Biochemistry and Biophysics, April 2011, pages 164-170
  • Antioxidants and Redox Signaling, December 2001, pages 1041-1064

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Frequently asked questions

What ingredients are in 345 Relief Serum?

WATER, BETULA PLATYPHYLLA JAPONICA JUICE, PROPANEDIOL, MELALEUCA ALTERNIFOLIA LEAF WATER, DIPROPYLENE GLYCOL, BUTYLENE GLYCOL, GLYCERIN, NIACINAMIDE, PANTHENOL, 1,2-HEXANEDIOL, CAPRYLIC/CAPRIC TRIGLYCERIDE, HYDROGENATED POLYDECENE, C14-22 ALCOHOLS, HYDROXYACETOPHENONE, ACRYLATES/C10-30 ALKYL ACRYLATE CROSSPOLYMER, C12-20 ALKYL GLUCOSIDE, TROMETHAMINE, GLYCERYL CAPRYLATE, ETHYLHEXYLGLYCERIN, XANTHAN GUM, PENTYLENE GLYCOL, DISODIUM EDTA, CAPRYLYL GLYCOL, CAMELLIA SINENSIS LEAF WATER, HYDROLYZED HYALURONIC ACID, HYALURONIC ACID, SODIUM HYALURONATE, POLOXAMER 407, SODIUM HYALURONATE CROSSPOLYMER, HYDROGENATED LECITHIN, MADECASSOSIDE, PANTOTHENIC ACID, POLYGLUTAMIC ACID, DECYL GLUCOSIDE, ASIATICOSIDE, BETA-GLUCAN, ASIATIC ACID, MADECASSIC ACID, SODIUM PHYTATE, SODIUM DNA, CERAMIDE NP, ALUMINUM/MAGNESIUM HYDROXIDE STEARATE, CENTELLA ASIATICA EXTRACT, CHOLESTEROL, LYSOLECITHIN, PHOSPHATIDYLCHOLINE, XYLOSE, HYDROXYPROPYL CYCLODEXTRIN, TANNIC ACID, RESVERATROL.

What are the active ingredients in 345 Relief Serum?

NIACINAMIDE, PANTHENOL, HYDROLYZED HYALURONIC ACID, HYALURONIC ACID, SODIUM HYALURONATE, SODIUM HYALURONATE CROSSPOLYMER, PANTOTHENIC ACID, CERAMIDE NP.

How do I use 345 Relief Serum?

Layer the serum before 345 Relief Cream to pair lightweight hydration with a comforting moisturizer.

What skin types is 345 Relief Serum good for?

Judged on how rich the formula reads from its ingredient list, it suits Combination (oily), Oily skin best. It is the least natural fit for Dry, Combination (dry) skin.

Is 345 Relief Serum good for sensitive skin?

No ingredient in this formula carries a common-irritant flag, making it a reasonable option for reactive skin. A patch test is still recommended, as individual skin reactivity varies.

Is 345 Relief Serum fungal acne safe?

2 ingredients could feed malassezia: Glyceryl Caprylate, Aluminum/magnesium Hydroxide Stearate. That describes the yeast's food supply, not a prediction that they will cause a breakout.

Can I use 345 Relief Serum while pregnant?

Nothing in this formula is on the standard pregnancy-caution list. That is not medical clearance — check anything you use daily with your doctor or midwife.

Is 345 Relief Serum fragrance free?

Yes. Reading the full ingredient list, this formula is fragrance-free.

Does 345 Relief Serum contain alcohol?

No. Reading the full ingredient list, this formula is no drying alcohol.

Is 345 Relief Serum silicone free?

Yes. Reading the full ingredient list, this formula is silicone-free.

Does 345 Relief Serum contain essential oils?

No. Reading the full ingredient list, this formula is essential-oil-free.

Is 345 Relief Serum paraben free?

Yes. Reading the full ingredient list, this formula is paraben-free.

What can I layer with 345 Relief Serum?

It layers well with Vitamin C (L-ascorbic acid), Retinoids (retinol, retinal), AHAs (glycolic, lactic), BHA (salicylic acid), PHAs (gluconolactone), Benzoyl peroxide.

When should I apply 345 Relief Serum?

Use it morning and evening, after toner, before moisturiser.

How many ingredients does 345 Relief Serum have?

It lists 50 ingredients, of which 8 are recorded as actives.

Who makes 345 Relief Serum?

Dr.Althea.

Brand
Dr.Althea

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