1st on the list, which puts it at an estimated 30–80% of the formula.
Aqua (EU),Deionized Water,Distilled Water,Micromatrix Fractile AN,Onsen-Sui (JPN),Purified Water
Isntree
TW-Real Bifida Ampoule
face ampoule
Isntree
face ampoule
Added Last edited
Fit by skin type
General, ingredient-based — not your personalized match.
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Take the skin testThe ISNTREE TW-Real Bifida Ampoule is a lightweight nourishing ampoule formulated with a high concentration of Bifida Ferment Lysate to help improve skin elasticity and support a healthy skin barrier. Enriched with Niacinamide, Peptides, and Fermented Extracts, it helps smooth the appearance of fine lines, brighten dull skin, and keep the skin hydrated without a sticky finish. The fast-absorbing formula leaves the skin looking firmer, healthier, and refreshed, making it suitable for daily use on all skin types.
TW-Real Bifida Ampoule is a lightweight ampoule from Isntree. The formula is built mainly around hydration and soothing. The ingredient list runs to 30 ingredients, each broken down in full below.
By its ingredient list the formula reads as light: water and humectants lead, with emollients kept lower in the order. Hydration is handled by Butylene Glycol, Glycerin and Panthenol, humectants that pull water into the upper layers of skin rather than sealing it there.
Hydration: High. Ingredients that pull and hold water in the upper layers of skin, and here that comes from Butylene Glycol, Glycerin, Panthenol and Sodium Hyaluronate.
Soothing: High. Ingredients aimed at visible redness and reactivity, and here that comes from Panthenol, Allantoin, Beta-glucan and Bifida Ferment Lysate.
Barrier support: Moderate. Lipids and repair signals that support skin barrier integrity, and here that comes from Niacinamide and Panthenol.
Brightening: Moderate. Ingredients that act on uneven tone and post-inflammatory marks, and here that comes from Niacinamide, Scutellaria Baicalensis Root Extract and Lactobacillus/rice Ferment Filtrate.
On richness alone it suits Balanced, Combination (oily) and Oily skin best, and is the least natural fit for Dry and Combination (dry) skin. Nothing in the list is flagged as a common irritant, which is a reasonable starting point for reactive skin — though a patch test is still the only way to know.
The formula contributes little or nothing on antioxidant protection and cell renewal. That is not a fault — most products are not meant to do everything — but if one of those is your priority, this is not the product that will address it.
Reading the full list, the formula is fragrance-free, essential-oil-free, no drying alcohol, paraben-free, silicone-free and microplastic-free. Those claims come from the ingredient list itself, not from the packaging.
It can be used morning and evening. In a routine it goes after toner, before moisturiser. Apply to clean, dry skin and give it a minute to absorb before the next layer. Introduce one new treatment at a time so you can identify what is working.
This summary is generated from the product's ingredient list. It is not a review, it is not the brand's own marketing claims, and it does not replace advice from a dermatologist.
Drawn purely from the ingredient list
Scored on how rich or light the formula reads from its INCI order.
No ingredient in this formula carries a common-irritant flag, making it a reasonable option for reactive skin. A patch test is still recommended, as individual skin reactivity varies.
Based on the curated benefits documented for this product's ingredients.
Attracts and locks in moisture to keep skin plump and dewy
Calms redness, irritation, and inflammation for sensitive skin
Boosts collagen and cell turnover to reduce fine lines and wrinkles
Brightens and balances complexion for a more uniform appearance
Tightens and refines the look of enlarged pores
None of the ingredients in this formula are associated with these benefits. This is not unusual, as most products are designed to target a limited number of concerns.
The actives, UV filters and benefit-carrying ingredients in this formula, in the order they are listed.
1st on the list, which puts it at an estimated 30–80% of the formula.
Aqua (EU),Deionized Water,Distilled Water,Micromatrix Fractile AN,Onsen-Sui (JPN),Purified Water
2nd on the list, which puts it at an estimated 5–20% of the formula.
Butane-1,3-diol (CAS No. 107-88-0/ EC No. 203-529-7) (R)-(-)-butane-1,3-diol” (CAS No. 6290-03-5/ EC No. 228-532-0)
4th on the list, which puts it at an estimated 2–10% of the formula.
Glycerine ;Glycerol (INN); Glycerol (RIFM); Glycerolum (EP); Glycyl Alcohol; 1,2,3-Propanetriol; 1,2,3-Trihydroxypropane
5th on the list, which puts it at an estimated 2–10% of the formula.
Bifida Ferment Lysate is a lysate of the product obtained by the fermentation of Bifida
6th on the list, which puts it at an estimated 2–10% of the formula.
Niacinamide (vitamin B3) is a gentle skincare active that repairs the skin barrier, calms redness, controls oil and evens tone at 2–5%. Official IUPAC name: **3-Pyridinecarboxamide**
8th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (2R)-; dl-Panthenol
11th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Urea, (2,5-dioxo-4-imidazolidinyl)-
13th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
L-Arginine
14th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
6-Amino-9-beta-D-ribofuranosyl-9H-purine
15th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Scutellaria Baicalensis Root Extract is an extract of the roots of the Scutellaria baicalensis, Lamiaceae
17th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Hyaluronic acid, sodium, salt
18th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Lactobacillus/Rice Ferment Filtrate is a filtrate of the product of the fermentation of Oryza Sativa (Rice) by the microorganism, Lactobacillus
Each axis is scored from the ingredients present and how high up the list they sit.
Ingredients that pull and hold water in the upper layers of skin
Lipids and repair signals that support skin barrier integrity
Ingredients that mop up free radicals from UV and pollution
Ingredients that moderate sebum or absorb shine
Ingredients that act on uneven tone and post-inflammatory marks
Ingredients aimed at visible redness and reactivity
Retinoids, acids and enzymes that speed surface turnover
Peptides and growth factors that signal for collagen support
"Active" here means an ingredient carrying a recorded active type or a recognised UV filter.
Solvents, emollients, texture agents and preservatives — the formula that carries the actives.
Read from the full ingredient list. A brand's own claim may differ.
Judged by the same curated rules our routine checker uses. It reads the ingredients, not the label.
Best kept to separate routines — one in the morning, one at night, or on alternate days.
This product is the "Treat" step.
Flags to check, not verdicts. None of this is medical advice — if you are pregnant, breastfeeding or treating a skin condition, ask a doctor.
Most ingredients do more than one job, so these counts add up to more than the 30 ingredients on the label.
Botanical material, usually for antioxidants or scent
Changes how skin behaves rather than how it feels
Draws water into the upper layers of skin
Sets the thickness, spread and stability of the formula
Forms a film that slows water loss
Dissolves and carries everything else
Calms visible redness and irritation
Amino-acid chains that signal for repair or firmness
Softens and smooths by filling gaps between skin cells
Binds trace metals that would otherwise spoil the formula
Every ingredient on the label, in order, with what it does and roughly how much of it is likely to be there.
1st on the list, which puts it at an estimated 30–80% of the formula.
Aqua (EU),Deionized Water,Distilled Water,Micromatrix Fractile AN,Onsen-Sui (JPN),Purified Water
2nd on the list, which puts it at an estimated 5–20% of the formula.
Butane-1,3-diol (CAS No. 107-88-0/ EC No. 203-529-7) (R)-(-)-butane-1,3-diol” (CAS No. 6290-03-5/ EC No. 228-532-0)
3rd on the list, which puts it at an estimated 5–20% of the formula.
1,1'-Oxydipropan-2-ol; Oxydipropan-2-ol; Hydroxypropyloxypropanol
4th on the list, which puts it at an estimated 2–10% of the formula.
Glycerine ;Glycerol (INN); Glycerol (RIFM); Glycerolum (EP); Glycyl Alcohol; 1,2,3-Propanetriol; 1,2,3-Trihydroxypropane
5th on the list, which puts it at an estimated 2–10% of the formula.
Bifida Ferment Lysate is a lysate of the product obtained by the fermentation of Bifida
6th on the list, which puts it at an estimated 2–10% of the formula.
Niacinamide (vitamin B3) is a gentle skincare active that repairs the skin barrier, calms redness, controls oil and evens tone at 2–5%. Official IUPAC name: **3-Pyridinecarboxamide**
7th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
8th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (2R)-; dl-Panthenol
9th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Illicium Verum Fruit Extract is an extract obtained from the fruits of the Star Anise, Illicium verum, Illiciaceae
10th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Cellulose, 2-hydroxyethyl ether
11th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Urea, (2,5-dioxo-4-imidazolidinyl)-
12th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
2-Propenoic acid, polymer with 2,2-bis(hydroxymethyl)propane-1,3-diol 2-propenyl ether
13th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
L-Arginine
14th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
6-Amino-9-beta-D-ribofuranosyl-9H-purine
15th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Scutellaria Baicalensis Root Extract is an extract of the roots of the Scutellaria baicalensis, Lamiaceae
16th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Disodium dihydrogen ethylenediaminetetraacetate
17th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Hyaluronic acid, sodium, salt
18th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Lactobacillus/Rice Ferment Filtrate is a filtrate of the product of the fermentation of Oryza Sativa (Rice) by the microorganism, Lactobacillus
19th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Salix Alba Bark Extract is an extract of the bark of the White Willow, Salix alba L., salicaceae
20th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Origanum Vulgare Leaf Extract is an extract of the leaves of the Wild Marjoram, Origanum vulgare L., Labiatae
21st on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Collagens, hydrolyzates. Substance obtained by acidic, alkaline, or enzymatic hydrolysis of hoofs and horns composed primarily of amino acids, peptides, and proteins. It may contain impurities consisting chiefly of carbohydrates and lipids along with smaller quantities of miscellaneous organic substances of biological origin.
22nd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Chamaecyparis Obtusa Leaf Extract is the extract of the leaves of Chamaecyparis obtusa, Cupressaceae
23rd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Portulaca Oleracea Extract is an extract of the whole plant of the Purselane, Portulaca oleracea L., Portulacaceae
24th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Lactobacillus/Soybean Ferment Extract is an extract of the fermentation of soybean by the microorganism Lactobacillus
25th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Lactobacillus/Pumpkin Ferment Extract is the extract of the product obtained by the fermentation of the fruit of Curcurbita pepo (pumpkin) by the microorganism, Lactobacillus.
26th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Cinnamomum Cassia Bark Extract is an extract obtained from the dried bark of the Chinese Cinnamon, Cinnamomum cassia (L.), Lauraceae
27th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
beta-Glucan is a polysaccharide consisting of b(1-3) linked glucose chains carrying b(1-6) linked glucose sidechains
28th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
L-Lysine, N-(1-oxohexadecyl)glycyl-L-histidyl-
29th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Acetyl hexapeptide-8 is the synthetic peptide consisting of arginine, methionine, and acetylated glutamic acid residues
30th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Copper Tripeptide-1 is a copper complex of Tripeptide-1
Products in the same category that share this formula's distinguishing ingredients.
SUNGBOON EDITOR
Shares 10 key ingredients with TW-Real Bifida Ampoule: Water, Butylene Glycol, Glycerin, Niacinamide, Adenosine
Missha
Shares 10 key ingredients with TW-Real Bifida Ampoule: Glycerin, Butylene Glycol, Niacinamide, Water, Bifida Ferment Lysate
Dr.Melaxin
Shares 9 key ingredients with TW-Real Bifida Ampoule: Water, Butylene Glycol, Glycerin, Niacinamide, Panthenol
Benton
Shares 9 key ingredients with TW-Real Bifida Ampoule: Water, Butylene Glycol, Glycerin, Panthenol, Arginine
SKIN1004
Shares 9 key ingredients with TW-Real Bifida Ampoule: Butylene Glycol, Glycerin, Water, Niacinamide, Arginine
VT Cosmetics
Shares 9 key ingredients with TW-Real Bifida Ampoule: Water, Glycerin, Arginine, Adenosine, Allantoin
WATER, BUTYLENE GLYCOL, DIPROPYLENE GLYCOL, GLYCERIN, BIFIDA FERMENT LYSATE, NIACINAMIDE, 1,2-HEXANEDIOL, PANTHENOL, ILLICIUM VERUM FRUIT EXTRACT, HYDROXYETHYLCELLULOSE, ALLANTOIN, CARBOMER, ARGININE, ADENOSINE, SCUTELLARIA BAICALENSIS ROOT EXTRACT, DISODIUM EDTA, SODIUM HYALURONATE, LACTOBACILLUS/RICE FERMENT FILTRATE, SALIX ALBA BARK EXTRACT, ORIGANUM VULGARE LEAF EXTRACT, HYDROLYZED COLLAGEN, CHAMAECYPARIS OBTUSA LEAF EXTRACT, PORTULACA OLERACEA EXTRACT, LACTOBACILLUS/SOYBEAN FERMENT EXTRACT, LACTOBACILLUS/PUMPKIN FERMENT EXTRACT, CINNAMOMUM CASSIA BARK EXTRACT, BETA-GLUCAN, PALMITOYL TRIPEPTIDE-1, ACETYL HEXAPEPTIDE-8, COPPER TRIPEPTIDE-1.
NIACINAMIDE, PANTHENOL, SODIUM HYALURONATE, PALMITOYL TRIPEPTIDE-1, ACETYL HEXAPEPTIDE-8, COPPER TRIPEPTIDE-1.
Apply 2-3 drops to a cleansed skin. Dab the serum into the skin until completely absorbed.
Judged on how rich the formula reads from its ingredient list, it suits Balanced, Combination (oily), Oily skin best. It is the least natural fit for Dry, Combination (dry) skin.
No ingredient in this formula carries a common-irritant flag, making it a reasonable option for reactive skin. A patch test is still recommended, as individual skin reactivity varies.
4 ingredients could feed malassezia: Bifida Ferment Lysate, Lactobacillus/rice Ferment Filtrate, Lactobacillus/soybean Ferment Extract, Lactobacillus/pumpkin Ferment Extract. That describes the yeast's food supply, not a prediction that they will cause a breakout.
Nothing in this formula is on the standard pregnancy-caution list. That is not medical clearance — check anything you use daily with your doctor or midwife.
Yes. Reading the full ingredient list, this formula is fragrance-free.
No. Reading the full ingredient list, this formula is no drying alcohol.
Yes. Reading the full ingredient list, this formula is silicone-free.
No. Reading the full ingredient list, this formula is essential-oil-free.
Yes. Reading the full ingredient list, this formula is paraben-free.
It layers well with Vitamin C (L-ascorbic acid), Retinoids (retinol, retinal), AHAs (glycolic, lactic), BHA (salicylic acid), PHAs (gluconolactone), Azelaic acid. Take more care combining it with Benzoyl peroxide — use them in separate routines or on alternate days.
Use it morning and evening, after toner, before moisturiser.
It lists 30 ingredients, of which 6 are recorded as actives.
Isntree.
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