Mizon Peptide 500

Mizon

Peptide 500

face serum

Added Last edited

Fit by skin type

General, ingredient-based — not your personalized match.

Dry
60%
Combination (dry)
60%
Balanced
75%
Combination (oily)
95%
Oily
95%

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20
Ingredients
3
Benefits
3
Actives
Find Dupes

The Mizon Peptide 500 is a lightweight and silky serum addressing wrinkles and fine lines. This tried-and-true ingredient is known to help hydrate, firm, and lift skin to provide a more youthful complexion. It contains several potent peptide ingredients that are combined to create a strong defense against signs of aging. Recommended for: All skin types.

Key Insights

Benefits

3
Anti-Aging
Hydration
Soothing

Active Ingredients

3
Carrier peptides Hyaluronic acid Neuropeptides

Full Ingredients

20 total
WATER METHYLPROPANEDIOL BUTYLENE GLYCOL GLYCERIN PENTYLENE GLYCOL PEG-60 HYDROGENATED CASTOR OIL 1,2-HEXANEDIOL SODIUM HYALURONATE Hyaluronic acid PROPANEDIOL ETHYLHEXYLGLYCERIN COPPER TRIPEPTIDE-1 Carrier peptides ADENOSINE BETA-GLUCAN DISODIUM EDTA CENTELLA ASIATICA EXTRACT HOUTTUYNIA CORDATA EXTRACT SALVIA HISPANICA SEED EXTRACT CAPRYLYL GLYCOL ACETYL HEXAPEPTIDE-8 Neuropeptides PHENOXYETHANOL

About Peptide 500

Overview

Peptide 500 is a watery-light serum from Mizon. The formula is built mainly around hydration. The ingredient list runs to 20 ingredients, each broken down in full below.

Texture and finish

By its ingredient list the formula reads as very light — essentially a water-and-humectant base with little emollient weight. With almost no emollient load it should absorb quickly and finish close to matte. Hydration is handled by Methylpropanediol, Butylene Glycol and Glycerin, humectants that pull water into the upper layers of skin rather than sealing it there.

What the formula does

Hydration: Very high. Ingredients that pull and hold water in the upper layers of skin, and here that comes from Methylpropanediol, Butylene Glycol, Glycerin and Sodium Hyaluronate.

Soothing: Moderate. Ingredients aimed at visible redness and reactivity, and here that comes from Beta-glucan, Centella Asiatica Extract, Sodium Hyaluronate and Adenosine.

Who it suits

On richness alone it suits Combination (oily) and Oily skin best, and is the least natural fit for Dry and Combination (dry) skin. Nothing in the list is flagged as a common irritant, which is a reasonable starting point for reactive skin — though a patch test is still the only way to know.

What it does not target

The formula contributes little or nothing on barrier support, antioxidant protection, oil control and brightening and tone. That is not a fault — most products are not meant to do everything — but if one of those is your priority, this is not the product that will address it.

What is not in it

Reading the full list, the formula is fragrance-free, essential-oil-free, no drying alcohol, paraben-free, silicone-free and microplastic-free. Those claims come from the ingredient list itself, not from the packaging.

Where it fits in a routine

It can be used morning and evening. In a routine it goes after toner, before moisturiser. Apply to clean, dry skin and give it a minute to absorb before the next layer. Introduce one new treatment at a time so you can identify what is working.

This summary is generated from the product's ingredient list. It is not a review, it is not the brand's own marketing claims, and it does not replace advice from a dermatologist.

Pros and cons

Drawn purely from the ingredient list

Pros

  • No fragrance or declared allergens
  • No essential oils
  • No drying alcohol
  • Silicone-free
  • No microplastics
  • Strong humectant content for hydration
  • No common irritants flagged in the list
  • No recognised malassezia (fungal acne) triggers

Which skin types it suits

Scored on how rich or light the formula reads from its INCI order.

Suitable for

  • Combination (oily) skin
  • Oily skin

May suit

  • Balanced skin

Less suitable for

  • Dry skin
  • Combination (dry) skin

Sensitive skin

No ingredient in this formula carries a common-irritant flag, making it a reasonable option for reactive skin. A patch test is still recommended, as individual skin reactivity varies.

Skin concerns

Based on the curated benefits documented for this product's ingredients.

Helps with

  • Hydration 11 ingredients

    Attracts and locks in moisture to keep skin plump and dewy

  • Anti-Aging 5 ingredients

    Boosts collagen and cell turnover to reduce fine lines and wrinkles

  • Soothing 5 ingredients

    Calms redness, irritation, and inflammation for sensitive skin

Does not target

Anti-Acne Blackhead Reducing Dark Spot Fading Evens Skin Tone Oil Control Pore Minimizer Smooths Bumpy Skin

None of the ingredients in this formula are associated with these benefits. This is not unusual, as most products are designed to target a limited number of concerns.

Key ingredients

The actives, UV filters and benefit-carrying ingredients in this formula, in the order they are listed.

Water

1st on the list, which puts it at an estimated 30–80% of the formula.

Aqua (EU),Deionized Water,Distilled Water,Micromatrix Fractile AN,Onsen-Sui (JPN),Purified Water

Hydration
Methylpropanediol

2nd on the list, which puts it at an estimated 5–20% of the formula.

2-Methyl-1,3-propanediol

Hydration
Butylene Glycol

3rd on the list, which puts it at an estimated 5–20% of the formula.

Butane-1,3-diol (CAS No. 107-88-0/ EC No. 203-529-7) (R)-(-)-butane-1,3-diol” (CAS No. 6290-03-5/ EC No. 228-532-0)

Hydration
Glycerin

4th on the list, which puts it at an estimated 2–10% of the formula.

Glycerine ;Glycerol (INN); Glycerol (RIFM); Glycerolum (EP); Glycyl Alcohol; 1,2,3-Propanetriol; 1,2,3-Trihydroxypropane

Hydration Anti-Aging
Pentylene Glycol

5th on the list, which puts it at an estimated 2–10% of the formula.

1,2-Dihydroxypentane

Hydration
Peg-60 Hydrogenated Castor Oil

6th on the list, which puts it at an estimated 2–10% of the formula.

Castor oil (Ricinus communis), hydrogenated, ethoxylated (60 mol EO average molar ratio)

Hydration
Sodium Hyaluronate Hyaluronic acid

8th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Hyaluronic acid, sodium, salt

Hydration Anti-Aging Soothing
Propanediol

9th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

1,3-dihydroxypropane

Hydration
Ethylhexylglycerin

10th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

1,2-Propanediol, 3-(2-ethylhexyloxy)

Hydration
Copper Tripeptide-1 Carrier peptides

11th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Copper Tripeptide-1 is a copper complex of Tripeptide-1

Adenosine

12th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

6-Amino-9-beta-D-ribofuranosyl-9H-purine

Soothing
Beta-glucan

13th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

beta-Glucan is a polysaccharide consisting of b(1-3) linked glucose chains carrying b(1-6) linked glucose sidechains

Soothing Hydration

Formula analysis

Each axis is scored from the ingredients present and how high up the list they sit.

Hydration Very high

Ingredients that pull and hold water in the upper layers of skin

Barrier support None

Lipids and repair signals that support skin barrier integrity

Antioxidant support None

Ingredients that mop up free radicals from UV and pollution

Oil control None

Ingredients that moderate sebum or absorb shine

Brightening None

Ingredients that act on uneven tone and post-inflammatory marks

Soothing Moderate

Ingredients aimed at visible redness and reactivity

Cell renewal None

Retinoids, acids and enzymes that speed surface turnover

Firmness signalling Low

Peptides and growth factors that signal for collagen support

Active and supporting ingredients

"Active" here means an ingredient carrying a recorded active type or a recognised UV filter.

Active ingredients (3)

Supporting ingredients (17)

Solvents, emollients, texture agents and preservatives — the formula that carries the actives.

Water Methylpropanediol Butylene Glycol Glycerin Pentylene Glycol Peg-60 Hydrogenated Castor Oil 1,2-hexanediol Propanediol Ethylhexylglycerin Adenosine Beta-glucan Disodium Edta Centella Asiatica Extract Houttuynia Cordata Extract Salvia Hispanica Seed Extract Caprylyl Glycol Phenoxyethanol

What is and is not in it

Read from the full ingredient list. A brand's own claim may differ.

Free from

  • Fragrance-free
  • Essential-oil-free
  • No drying alcohol
  • Paraben-free
  • Silicone-free
  • Microplastic-free
  • Sulfate-free
  • Dye-free
  • Oil-free
  • No animal-derived ingredients

What to layer it with

Judged by the same curated rules our routine checker uses. It reads the ingredients, not the label.

Compatible with

  • Vitamin C (L-ascorbic acid)
  • Retinoids (retinol, retinal)
  • AHAs (glycolic, lactic)
  • BHA (salicylic acid)
  • PHAs (gluconolactone)
  • Azelaic acid
  • Copper peptides
  • Bakuchiol
  • Niacinamide
  • Hyaluronic acid
  • Ceramides
  • Signal peptides
  • Panthenol
  • Sunscreen

Use with caution

  • Benzoyl peroxide

    Best kept to separate routines — one in the morning, one at night, or on alternate days.

Where it fits in a routine

Morning Evening
  1. Cleanse
  2. Toning
  3. Treat
  4. Moisturise
  5. Protect

This product is the "Treat" step.

  • Apply to clean, dry skin and give it a minute to absorb before the next layer.
  • Introduce one new treatment at a time so you can identify what is working.

Safety and suitability

Flags to check, not verdicts. None of this is medical advice — if you are pregnant, breastfeeding or treating a skin condition, ask a doctor.

Pregnancy and breastfeeding
Nothing in this formula is on the standard pregnancy-caution list. That is not clearance — ask your doctor about anything you use daily.
Fungal acne (malassezia)
No ingredient here is a recognised food source for malassezia.
Sensitive and reactive skin
No ingredient in this formula carries a common-irritant flag, making it a reasonable option for reactive skin. A patch test is still recommended, as individual skin reactivity varies.

Ingredients by function

Most ingredients do more than one job, so these counts add up to more than the 20 ingredients on the label.

7
Solvent

Dissolves and carries everything else

4
Humectant

Draws water into the upper layers of skin

4
Texture agent

Sets the thickness, spread and stability of the formula

3
Active

Changes how skin behaves rather than how it feels

3
Plant extract

Botanical material, usually for antioxidants or scent

2
Emollient

Softens and smooths by filling gaps between skin cells

2
Peptide

Amino-acid chains that signal for repair or firmness

2
Surfactant

Lifts oil and dirt, or holds oil and water together

1
Soothing

Calms visible redness and irritation

1
Chelator

Binds trace metals that would otherwise spoil the formula

1
Occlusive

Forms a film that slows water loss

1
Preservative

Keeps the product free of microbial growth

Ingredient breakdown

Every ingredient on the label, in order, with what it does and roughly how much of it is likely to be there.

1 Water Solvent
Estimated level
30–80%
Confidence
Moderate — INCI order above the 1% line
Roles
Solvent

1st on the list, which puts it at an estimated 30–80% of the formula.

Aqua (EU),Deionized Water,Distilled Water,Micromatrix Fractile AN,Onsen-Sui (JPN),Purified Water

Hydration
3 scientific references
  • Skin Research and Technology, May 2015, pages 131-136
  • Skin Pharmacology and Applied Skin Physiology, November-December 1999, pages 344-351
  • Journal of Cosmetic Science, September-October 1993, pages 249-262
2 Methylpropanediol Solvent
Estimated level
5–20%
Confidence
Moderate — INCI order above the 1% line
Roles
Solvent

2nd on the list, which puts it at an estimated 5–20% of the formula.

2-Methyl-1,3-propanediol

Hydration
3 scientific references
  • PubChem, Accessed April 2021, ePublication
  • Cosmetic Ingredient Review, June 2018, pages 1-73
  • Contact Dermatitis, September 2017, pages 159-162
3 Butylene Glycol Humectant
Estimated level
5–20%
Confidence
Moderate — INCI order above the 1% line
Roles
Humectant, Texture agent, Solvent

3rd on the list, which puts it at an estimated 5–20% of the formula.

Butane-1,3-diol (CAS No. 107-88-0/ EC No. 203-529-7) (R)-(-)-butane-1,3-diol” (CAS No. 6290-03-5/ EC No. 228-532-0)

Hydration
5 scientific references
  • CosmeticsInfoorg, Accessed March 2021, ePublication
  • US Food and Drug Administration Code of Federal Regulations</em>, Accessed March 2021, ePublication
  • International Journal of Toxicology, May 2011, pages 5S-16S
  • Skin Research and Technology, November 2007, pages 417-24
  • Journal of the American College of Toxicology, September 1985, pages 223-248
4 Glycerin Humectant
Estimated level
2–10%
Confidence
Moderate — INCI order above the 1% line
Roles
Humectant, Occlusive, Texture agent, Solvent

4th on the list, which puts it at an estimated 2–10% of the formula.

Glycerine ;Glycerol (INN); Glycerol (RIFM); Glycerolum (EP); Glycyl Alcohol; 1,2,3-Propanetriol; 1,2,3-Trihydroxypropane

Hydration Anti-Aging
6 scientific references
  • Journal of Pharmaceutical Investigation, March 2021, pages 223-231
  • International Journal of Toxicology, November/December 2019, Volume 38, Supplement 3, pages 6S-22S
  • International Journal of Cosmetic Science, August 2016, ePublication
  • British Journal of Dermatology, July 2008, pages 23-34
  • Journal of Cosmetic Dermatology, June 2007, pages 75-82
  • Proceedings of the National Academy of Sciences, June 2003, pages 7, 360-7, 365
5 Pentylene Glycol Solvent
Estimated level
2–10%
Confidence
Moderate — INCI order above the 1% line
Roles
Solvent

5th on the list, which puts it at an estimated 2–10% of the formula.

1,2-Dihydroxypentane

Hydration
4 scientific references
  • https://thedermreviewcom/pentylene-glycol/
  • Regulatory Toxicology and Pharmacology, July 2017, pages 106-111
  • Prospector, June 2015, ePublication
  • International Journal of Toxicology, October 2012, pages 147S-168S
6 Peg-60 Hydrogenated Castor Oil Surfactant
Estimated level
2–10%
Confidence
Moderate — INCI order above the 1% line
Roles
Surfactant

6th on the list, which puts it at an estimated 2–10% of the formula.

Castor oil (Ricinus communis), hydrogenated, ethoxylated (60 mol EO average molar ratio)

Hydration
7 1,2-hexanediol Solvent
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Solvent

7th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

8 Sodium Hyaluronate Humectant
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Humectant, Active

8th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Hyaluronic acid, sodium, salt

Hydration Anti-Aging Soothing
5 scientific references
  • Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und Verwandte Gebiete, December 2017, pages 987-993
  • Journal of Cosmetic Dermatology, July 2014, pages 277-287
  • Journal of Clinical and Aesthetic Dermatology, October 2012, pages 20-23
  • DermatoEndocrinology, July-December 2012, pages 253-258
  • Journal of Drugs in Dermatology, September 2011, pages 990-1000
9 Propanediol Texture agent
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Texture agent, Solvent

9th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

1,3-dihydroxypropane

Hydration
4 scientific references
  • PubChem Compound Summary, April 2021, ePublication
  • SpecialChem, Accessed April 2021, ePublication
  • Cosmetic Ingredient Review, June 2018, pages 1-73
  • Cosmetics & Toiletries, May 2013, pages 81-86
10 Ethylhexylglycerin
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

10th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

1,2-Propanediol, 3-(2-ethylhexyloxy)

Hydration
5 scientific references
  • PLoS One, October 2016, ePublication
  • Contact Dermatitis, May 2016, pages 281-288
  • International Journal of Toxicology, September 2013, pages 5S-21S
  • Personal Care, 2008, pages 1-4
  • Cosmetic Science Technology, 2006, pages 1-11
11 Copper Tripeptide-1 Active
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Active, Peptide

11th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Copper Tripeptide-1 is a copper complex of Tripeptide-1

12 Adenosine
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

12th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

6-Amino-9-beta-D-ribofuranosyl-9H-purine

Soothing
8 scientific references
  • PubChem, Accessed May 2021, ePublication
  • Cosmetic Ingredient Review, September 2020, pages 1-38
  • Experimental Dermatology, August 2014, pages 553-554
  • Journal of Investigative Dermatology, August 2011, pages 526-546
  • International Journal of Cosmetic Science, December 2006, pages 447-451
  • British Journal of Pharmacology, October 2008, issue 4, pages 475-486
  • PloS One, May 2008 (ePublication)
  • >International Journal of Cosmetic Science, August 2006, pages 447-451
13 Beta-glucan
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

13th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

beta-Glucan is a polysaccharide consisting of b(1-3) linked glucose chains carrying b(1-6) linked glucose sidechains

Soothing Hydration
6 scientific references
  • Journal of Cosmetic Dermatology, December 2018, pages 1, 101-1, 107
  • International Journal of Molecular Sciences, September 2017, pages 1-48
  • Phytotherapy Research, February 2014, pages 159-166
  • Cosmetic Ingredient Review, October 2012, pages 1-52
  • Journal of Drugs in Dermatology, February 2007, pages 167-170
  • International Journal of Cosmetic Science, October 2005, page 292
14 Disodium Edta Texture agent
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Texture agent, Chelator

14th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Disodium dihydrogen ethylenediaminetetraacetate

15 Centella Asiatica Extract Soothing
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Soothing, Surfactant, Plant extract

15th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Centella Asiatica Extract is the extract of the whole plant Hydrocotyl, Centella asiatica L., Apiaceae

Soothing Anti-Aging
6 scientific references
  • Phytomedicine, April 2018, pages 110–119
  • Clinical, Cosmetic, and Investigational Dermatology, August 2017, pages 311–315
  • Indian Journal of Pharmaceutical Sciences, Jan-Feb 2016, pages 27–33
  • Postepy Dermatologii I, February 2013, pages 46–49
  • Indian Journal of Pharmaceutical Sciences, 2010, pages 546–556
  • Scientific Reports, June 2021, ePublication
16 Houttuynia Cordata Extract Plant extract
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Plant extract

16th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Houttuynia Cordata Extract is an extract of the herb, Houttuynia cordata, Saururaceae

Anti-Aging Soothing
17 Salvia Hispanica Seed Extract Emollient
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Emollient, Plant extract

17th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Salvia Hispanica Seed Extract is an extract of the seeds of the Spanish Sage, Salvia hispanica L., Lamiaceae

18 Caprylyl Glycol Emollient
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Emollient

18th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Octane-1,2-diol

19 Acetyl Hexapeptide-8 Humectant
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Humectant, Active, Peptide

19th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Acetyl hexapeptide-8 is the synthetic peptide consisting of arginine, methionine, and acetylated glutamic acid residues

Anti-Aging Hydration
6 scientific references
  • Cosmetics, November 2020, Issue 7, Volume 4, page 91
  • La Clinica Terapeutica, November 2020, pages e539-e548
  • https://wwwcir-safetyorg/sites/default/files/AcetylHexapeptide-8pdf
  • Cutaneous and Ocular Toxicology, March 2015, pages 46-52
  • European Journal of Pharmaceutical Sciences, February 2015, pages 27-35
  • Dermatologic Therapy, September-October 2007, issue 5, pages 343-349
20 Phenoxyethanol Preservative
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Preservative

20th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

2-Phenoxyethanol

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Frequently asked questions

What ingredients are in Peptide 500?

WATER, METHYLPROPANEDIOL, BUTYLENE GLYCOL, GLYCERIN, PENTYLENE GLYCOL, PEG-60 HYDROGENATED CASTOR OIL, 1,2-HEXANEDIOL, SODIUM HYALURONATE, PROPANEDIOL, ETHYLHEXYLGLYCERIN, COPPER TRIPEPTIDE-1, ADENOSINE, BETA-GLUCAN, DISODIUM EDTA, CENTELLA ASIATICA EXTRACT, HOUTTUYNIA CORDATA EXTRACT, SALVIA HISPANICA SEED EXTRACT, CAPRYLYL GLYCOL, ACETYL HEXAPEPTIDE-8, PHENOXYETHANOL.

What are the active ingredients in Peptide 500?

SODIUM HYALURONATE, COPPER TRIPEPTIDE-1, ACETYL HEXAPEPTIDE-8.

How do I use Peptide 500?

Apply a suitable amount to a cleansed and toned face. Gently pat for better absorption.

What skin types is Peptide 500 good for?

Judged on how rich the formula reads from its ingredient list, it suits Combination (oily), Oily skin best. It is the least natural fit for Dry, Combination (dry) skin.

Is Peptide 500 good for sensitive skin?

No ingredient in this formula carries a common-irritant flag, making it a reasonable option for reactive skin. A patch test is still recommended, as individual skin reactivity varies.

Is Peptide 500 fungal acne safe?

No ingredient in this formula is a recognised food source for malassezia, the yeast behind fungal acne.

Can I use Peptide 500 while pregnant?

Nothing in this formula is on the standard pregnancy-caution list. That is not medical clearance — check anything you use daily with your doctor or midwife.

Is Peptide 500 fragrance free?

Yes. Reading the full ingredient list, this formula is fragrance-free.

Does Peptide 500 contain alcohol?

No. Reading the full ingredient list, this formula is no drying alcohol.

Is Peptide 500 silicone free?

Yes. Reading the full ingredient list, this formula is silicone-free.

Does Peptide 500 contain essential oils?

No. Reading the full ingredient list, this formula is essential-oil-free.

Is Peptide 500 paraben free?

Yes. Reading the full ingredient list, this formula is paraben-free.

What can I layer with Peptide 500?

It layers well with Vitamin C (L-ascorbic acid), Retinoids (retinol, retinal), AHAs (glycolic, lactic), BHA (salicylic acid), PHAs (gluconolactone), Azelaic acid. Take more care combining it with Benzoyl peroxide — use them in separate routines or on alternate days.

When should I apply Peptide 500?

Use it morning and evening, after toner, before moisturiser.

How many ingredients does Peptide 500 have?

It lists 20 ingredients, of which 3 are recorded as actives.

Who makes Peptide 500?

Mizon.

Brand
Mizon

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