1st on the list, which puts it at an estimated 30–80% of the formula.
Aqua (EU),Deionized Water,Distilled Water,Micromatrix Fractile AN,Onsen-Sui (JPN),Purified Water
IOPE
XMD Stem III Clinical Recovery Serum
face serum
IOPE
face serum
Added Last edited
Fit by skin type
General, ingredient-based — not your personalized match.
See how this fits your skin
Take the skin test and I'll show you how suitable this product is for you.
Take the skin testThis first-of-its-kind serum brings next-level PDRN technology to barrier strengthening, hydrating, and firming skin support with professional-level results. Designed for compromised, sensitive, or rough skin, this high-performance serum supports visible recovery while strengthening the skin barrier, improving elasticity, and smoothing the look of fine lines.
XMD Stem III Clinical Recovery Serum is a lightweight serum from IOPE, a brand based in Korea. The formula is built mainly around hydration. The ingredient list runs to 32 ingredients, each broken down in full below.
By its ingredient list the formula reads as light: water and humectants lead, with emollients kept lower in the order. Silicones in the formula tend to give a smooth, blurred finish and help it grip under makeup. Hydration is handled by Butylene Glycol, Glycerin and Betaine, humectants that pull water into the upper layers of skin rather than sealing it there.
Hydration: High. Ingredients that pull and hold water in the upper layers of skin, and here that comes from Butylene Glycol, Glycerin, Betaine and Propanediol.
Soothing: Moderate. Ingredients aimed at visible redness and reactivity, and here that comes from Allantoin, Asiaticoside, Niacinamide and Madecassic Acid.
Barrier support: Moderate. Lipids and repair signals that support skin barrier integrity, and here that comes from Niacinamide, Hydrogenated Lecithin and Cholesterol.
Oil control: Moderate. Ingredients that moderate sebum or absorb shine, and here that comes from Niacinamide and Dextrin.
On richness alone it suits Balanced, Combination (oily) and Oily skin best, and is the least natural fit for Dry and Combination (dry) skin. Nothing in the list is flagged as a common irritant, which is a reasonable starting point for reactive skin — though a patch test is still the only way to know.
The formula contributes little or nothing on antioxidant protection and cell renewal. That is not a fault — most products are not meant to do everything — but if one of those is your priority, this is not the product that will address it.
Reading the full list, the formula is fragrance-free, essential-oil-free, paraben-free, microplastic-free, sulfate-free and dye-free. Those claims come from the ingredient list itself, not from the packaging. It does contain drying alcohol, worth knowing if your skin reacts to any of them.
It can be used morning and evening. In a routine it goes after toner, before moisturiser. Apply to clean, dry skin and give it a minute to absorb before the next layer. Introduce one new treatment at a time so you can identify what is working.
This summary is generated from the product's ingredient list. It is not a review, it is not the brand's own marketing claims, and it does not replace advice from a dermatologist.
Drawn purely from the ingredient list
Scored on how rich or light the formula reads from its INCI order.
No ingredient in this formula carries a common-irritant flag, making it a reasonable option for reactive skin. A patch test is still recommended, as individual skin reactivity varies.
Based on the curated benefits documented for this product's ingredients.
Attracts and locks in moisture to keep skin plump and dewy
Boosts collagen and cell turnover to reduce fine lines and wrinkles
Calms redness, irritation, and inflammation for sensitive skin
Brightens and balances complexion for a more uniform appearance
Regulates sebum production to reduce shine and greasiness
Tightens and refines the look of enlarged pores
None of the ingredients in this formula are associated with these benefits. This is not unusual, as most products are designed to target a limited number of concerns.
The actives, UV filters and benefit-carrying ingredients in this formula, in the order they are listed.
1st on the list, which puts it at an estimated 30–80% of the formula.
Aqua (EU),Deionized Water,Distilled Water,Micromatrix Fractile AN,Onsen-Sui (JPN),Purified Water
2nd on the list, which puts it at an estimated 5–20% of the formula.
Butane-1,3-diol (CAS No. 107-88-0/ EC No. 203-529-7) (R)-(-)-butane-1,3-diol” (CAS No. 6290-03-5/ EC No. 228-532-0)
3rd on the list, which puts it at an estimated 5–20% of the formula.
Glycerine ;Glycerol (INN); Glycerol (RIFM); Glycerolum (EP); Glycyl Alcohol; 1,2,3-Propanetriol; 1,2,3-Trihydroxypropane
5th on the list, which puts it at an estimated 2–10% of the formula.
Niacinamide (vitamin B3) is a gentle skincare active that repairs the skin barrier, calms redness, controls oil and evens tone at 2–5%. Official IUPAC name: **3-Pyridinecarboxamide**
6th on the list, which puts it at an estimated 2–10% of the formula.
Methanaminium, 1-carboxy-N,N,N-trimethyl-, hydroxide, inner salt
7th on the list, which puts it at an estimated 1–5% of the formula.
Decanoic acid, ester with 1,2,3-propanetriol octanoate; Glycerides, mixed decanoyl and octanoyl
9th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Dimethicone
10th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Ammonium Acryloyldimethyltaurate/VP Copolymer is a copolymer of ammonium acryloyldimethyltaurate and vinylpyrrolidone monomers
11th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Ester of hexaglycerol and caprylic acid
13th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
1,3-dihydroxypropane
14th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Lecithins, hydrogenated
15th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Urea, (2,5-dioxo-4-imidazolidinyl)-
Each axis is scored from the ingredients present and how high up the list they sit.
Ingredients that pull and hold water in the upper layers of skin
Lipids and repair signals that support skin barrier integrity
Ingredients that mop up free radicals from UV and pollution
Ingredients that moderate sebum or absorb shine
Ingredients that act on uneven tone and post-inflammatory marks
Ingredients aimed at visible redness and reactivity
Retinoids, acids and enzymes that speed surface turnover
Peptides and growth factors that signal for collagen support
"Active" here means an ingredient carrying a recorded active type or a recognised UV filter.
Solvents, emollients, texture agents and preservatives — the formula that carries the actives.
Read from the full ingredient list. A brand's own claim may differ.
Alcohol
Dimethicone
Judged by the same curated rules our routine checker uses. It reads the ingredients, not the label.
Nothing in this formula belongs to a group our rules can put in conflict, so it layers freely. Order still matters — thinnest texture first.
This product is the "Treat" step.
Flags to check, not verdicts. None of this is medical advice — if you are pregnant, breastfeeding or treating a skin condition, ask a doctor.
Most ingredients do more than one job, so these counts add up to more than the 32 ingredients on the label.
Sets the thickness, spread and stability of the formula
Dissolves and carries everything else
Draws water into the upper layers of skin
Lifts oil and dirt, or holds oil and water together
Forms a film that slows water loss
Botanical material, usually for antioxidants or scent
Changes how skin behaves rather than how it feels
Neutralises free radicals from UV and pollution
Softens and smooths by filling gaps between skin cells
Calms visible redness and irritation
Amino-acid chains that signal for repair or firmness
Keeps the product free of microbial growth
Every ingredient on the label, in order, with what it does and roughly how much of it is likely to be there.
1st on the list, which puts it at an estimated 30–80% of the formula.
Aqua (EU),Deionized Water,Distilled Water,Micromatrix Fractile AN,Onsen-Sui (JPN),Purified Water
2nd on the list, which puts it at an estimated 5–20% of the formula.
Butane-1,3-diol (CAS No. 107-88-0/ EC No. 203-529-7) (R)-(-)-butane-1,3-diol” (CAS No. 6290-03-5/ EC No. 228-532-0)
3rd on the list, which puts it at an estimated 5–20% of the formula.
Glycerine ;Glycerol (INN); Glycerol (RIFM); Glycerolum (EP); Glycyl Alcohol; 1,2,3-Propanetriol; 1,2,3-Trihydroxypropane
4th on the list, which puts it at an estimated 2–10% of the formula.
1,1'-Oxydipropan-2-ol; Oxydipropan-2-ol; Hydroxypropyloxypropanol
5th on the list, which puts it at an estimated 2–10% of the formula.
Niacinamide (vitamin B3) is a gentle skincare active that repairs the skin barrier, calms redness, controls oil and evens tone at 2–5%. Official IUPAC name: **3-Pyridinecarboxamide**
6th on the list, which puts it at an estimated 2–10% of the formula.
Methanaminium, 1-carboxy-N,N,N-trimethyl-, hydroxide, inner salt
7th on the list, which puts it at an estimated 1–5% of the formula.
Decanoic acid, ester with 1,2,3-propanetriol octanoate; Glycerides, mixed decanoyl and octanoyl
8th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
9th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Dimethicone
10th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Ammonium Acryloyldimethyltaurate/VP Copolymer is a copolymer of ammonium acryloyldimethyltaurate and vinylpyrrolidone monomers
11th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Ester of hexaglycerol and caprylic acid
12th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
1,2,3-Propanetriol, homopolymer, decanoates (1:1) (4 mol glycerol average molar ratio)
13th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
1,3-dihydroxypropane
14th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Lecithins, hydrogenated
15th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Urea, (2,5-dioxo-4-imidazolidinyl)-
16th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Ethanol
17th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Urs-12-en-28-oic acid, 2,3,23-trihydroxy-, O-6-deoxy-alpha-L-mannopyranosyl-(1->4)-O-beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranosyl ester (2alpha, 3beta, 4alpha)-
18th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Sodium 2-[methyl(1-oxooctadecyl)amino]ethanesulphonate
19th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Urs-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-, (2alpha,3beta,4alpha,6beta)-
20th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Cholest-5-en-3-ol (beta)-
21st on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
D-Mannitol
22nd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Chlorella Protothecoides Extract
23rd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
(2.alpha.,3.beta.,4.alpha.)-2,3,23-Trihydroxyurs-12-en-28-oic acid
24th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
1,2-Propanediol, 3-(2-ethylhexyloxy)
25th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
6-Amino-9-beta-D-ribofuranosyl-9H-purine
26th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Deoxyribonucleic acid, hydrolyzed
27th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Dextrin
28th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Hyaluronic acid
29th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Theobroma Cacao Extract is the extract of Theobroma cacao., Sterculiaceae
30th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Allium Cepa Bulb Extract is an extract of the bulbs of the Onion, Allium cepa L., Liliaceae
31st on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Acetyl Tetrapeptide-11 is the reaction product of Acetic Acid and Tetrapeptide-11
32nd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ol; .alpha.-tocopherol; Vitamin E
Products in the same category that share this formula's distinguishing ingredients.
Missha
Shares 11 key ingredients with XMD Stem III Clinical Recovery Serum: Water, Glycerin, Propanediol, Niacinamide, Butylene Glycol
Arencia
Shares 10 key ingredients with XMD Stem III Clinical Recovery Serum: Water, Butylene Glycol, Glycerin, Propanediol, Niacinamide
innisfree
Shares 10 key ingredients with XMD Stem III Clinical Recovery Serum: Glycerin, Butylene Glycol, Niacinamide, Betaine, Hydrogenated Lecithin
Numbuzin
Shares 10 key ingredients with XMD Stem III Clinical Recovery Serum: Water, Butylene Glycol, Niacinamide, Glycerin, Propanediol
Medicube
Shares 10 key ingredients with XMD Stem III Clinical Recovery Serum: Water, Glycerin, Propanediol, Niacinamide, Betaine
Medicube
Shares 10 key ingredients with XMD Stem III Clinical Recovery Serum: Water, Niacinamide, Glycerin, Butylene Glycol, Caprylic/capric Triglyceride
WATER, BUTYLENE GLYCOL, GLYCERIN, DIPROPYLENE GLYCOL, NIACINAMIDE, BETAINE, CAPRYLIC/CAPRIC TRIGLYCERIDE, 1,2-HEXANEDIOL, DIMETHICONE, AMMONIUM ACRYLOYLDIMETHYLTAURATE/VP COPOLYMER, POLYGLYCERYL-6 CAPRYLATE, POLYGLYCERYL-4 CAPRATE, PROPANEDIOL, HYDROGENATED LECITHIN, ALLANTOIN, ALCOHOL, ASIATICOSIDE, SODIUM METHYL STEAROYL TAURATE, MADECASSIC ACID, CHOLESTEROL, MANNITOL, CHLORELLA PROTOTHECOIDES EXTRACT, ASIATIC ACID, ETHYLHEXYLGLYCERIN, ADENOSINE, HYDROLYZED DNA, DEXTRIN, HYALURONIC ACID, THEOBROMA CACAO EXTRACT, ALLIUM CEPA BULB EXTRACT, ACETYL TETRAPEPTIDE-11, TOCOPHEROL.
NIACINAMIDE, HYALURONIC ACID.
Pump 1–2 times and apply an even layer to the face at the serum step, morning and night. Gently massage until absorbed.
Judged on how rich the formula reads from its ingredient list, it suits Balanced, Combination (oily), Oily skin best. It is the least natural fit for Dry, Combination (dry) skin.
No ingredient in this formula carries a common-irritant flag, making it a reasonable option for reactive skin. A patch test is still recommended, as individual skin reactivity varies.
One ingredient could feed malassezia: Polyglyceryl-6 Caprylate. That describes the yeast's food supply, not a prediction that it will cause a breakout.
Nothing in this formula is on the standard pregnancy-caution list. That is not medical clearance — check anything you use daily with your doctor or midwife.
Yes. Reading the full ingredient list, this formula is fragrance-free.
Yes — it contains Alcohol.
No — it contains Dimethicone.
No. Reading the full ingredient list, this formula is essential-oil-free.
Yes. Reading the full ingredient list, this formula is paraben-free.
It layers well with Vitamin C (L-ascorbic acid), Retinoids (retinol, retinal), AHAs (glycolic, lactic), BHA (salicylic acid), PHAs (gluconolactone), Benzoyl peroxide.
Use it morning and evening, after toner, before moisturiser.
It lists 32 ingredients, of which 2 are recorded as actives.
IOPE, a brand based in Korea.
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