Numbuzin No.5 Glutathione TXA Advanced Dark Spot Ampoule Concentrate

Numbuzin

No.5 Glutathione TXA Advanced Dark Spot Ampoule Concentrate

face ampoule

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Fit by skin type

General, ingredient-based — not your personalized match.

Dry
53%
Combination (dry)
53%
Balanced
83%
Combination (oily)
87%
Oily
87%

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23
Ingredients
6
Benefits
3
Actives
Find Dupes

Concentrated ampoule designed to help improve the look of dark spots, post-acne marks, and uneven skin tone for a clearer, more even-looking complexion. Formulated with Glutathione and Tranexamic Acid (TXA) to support brighter-looking skin and help refine the appearance of discoloration over time.

Key Insights

Benefits

6
Anti-Aging
Dark Spot Fading
Evens Skin Tone
Hydration
Pore Minimizer
Soothing

Active Ingredients

3
Vitamin B3 (niacinamide) Vitamin B5 (panthenol) Vitamin C

Full Ingredients

23 total
HIPPOPHAE RHAMNOIDES WATER TRANEXAMIC ACID TRIPROPYLENE GLYCOL GLUTATHIONE NIACINAMIDE Vitamin B3 (niacinamide) 1,2-HEXANEDIOL DIETHOXYETHYL SUCCINATE HYDROXYACETOPHENONE HYDROXYETHYLCELLULOSE ETHYLHEXYLGLYCERIN DISODIUM EDTA ASCORBIC ACID Vitamin C BISABOLOL PANTHENOL Vitamin B5 (panthenol) TOCOPHEROL THIOCTIC ACID GLYCERIN WATER CYANOCOBALAMIN BUTYLENE GLYCOL CAPRYLIC/CAPRIC TRIGLYCERIDE POLYGLYCERYL-3 METHYLGLUCOSE DISTEARATE UBIQUINONE

About No.5 Glutathione TXA Advanced Dark Spot Ampoule Concentrate

Overview

No.5 Glutathione TXA Advanced Dark Spot Ampoule Concentrate is a lightweight ampoule from Numbuzin, a brand based in Korean. The ingredient list runs to 23 ingredients, each broken down in full below.

Texture and finish

By its ingredient list the formula reads as light: water and humectants lead, with emollients kept lower in the order.

What the formula does

Brightening: Moderate. Ingredients that act on uneven tone and post-inflammatory marks, and here that comes from Tranexamic Acid, Niacinamide, Ascorbic Acid and Tocopherol.

Antioxidant support: Moderate. Ingredients that mop up free radicals from UV and pollution, and here that comes from Glutathione, Ascorbic Acid, Tocopherol and Ubiquinone.

Soothing: Moderate. Ingredients aimed at visible redness and reactivity, and here that comes from Bisabolol, Panthenol, Niacinamide and Tocopherol.

Hydration: Moderate. Ingredients that pull and hold water in the upper layers of skin, and here that comes from Ethylhexylglycerin, Panthenol, Glycerin and Butylene Glycol.

Who it suits

On richness alone it suits Balanced, Combination (oily) and Oily skin best, and is the least natural fit for Dry and Combination (dry) skin. Nothing in the list is flagged as a common irritant, which is a reasonable starting point for reactive skin — though a patch test is still the only way to know.

What it does not target

The formula contributes little or nothing on cell renewal and firmness signalling. That is not a fault — most products are not meant to do everything — but if one of those is your priority, this is not the product that will address it.

What is not in it

Reading the full list, the formula is fragrance-free, essential-oil-free, no drying alcohol, paraben-free, silicone-free and microplastic-free. Those claims come from the ingredient list itself, not from the packaging.

Where it fits in a routine

It can be used morning and evening. In a routine it goes after toner, before moisturiser. Apply to clean, dry skin and give it a minute to absorb before the next layer. Introduce one new treatment at a time so you can identify what is working.

This summary is generated from the product's ingredient list. It is not a review, it is not the brand's own marketing claims, and it does not replace advice from a dermatologist.

Pros and cons

Drawn purely from the ingredient list

Pros

  • No fragrance or declared allergens
  • No essential oils
  • No drying alcohol
  • Silicone-free
  • No microplastics
  • No common irritants flagged in the list

Things to know

  • One ingredient could feed malassezia (fungal acne)

Which skin types it suits

Scored on how rich or light the formula reads from its INCI order.

Suitable for

  • Balanced skin
  • Combination (oily) skin
  • Oily skin

Less suitable for

  • Dry skin
  • Combination (dry) skin

Sensitive skin

No ingredient in this formula carries a common-irritant flag, making it a reasonable option for reactive skin. A patch test is still recommended, as individual skin reactivity varies.

Skin concerns

Based on the curated benefits documented for this product's ingredients.

Helps with

  • Anti-Aging 11 ingredients

    Boosts collagen and cell turnover to reduce fine lines and wrinkles

  • Hydration 7 ingredients

    Attracts and locks in moisture to keep skin plump and dewy

  • Soothing 5 ingredients

    Calms redness, irritation, and inflammation for sensitive skin

  • Evens Skin Tone 3 ingredients

    Brightens and balances complexion for a more uniform appearance

  • Dark Spot Fading 2 ingredients

    Fades hyperpigmentation and evens out dark spots over time

  • Pore Minimizer 1 ingredient

    Tightens and refines the look of enlarged pores

Does not target

Anti-Acne Blackhead Reducing Oil Control Smooths Bumpy Skin

None of the ingredients in this formula are associated with these benefits. This is not unusual, as most products are designed to target a limited number of concerns.

Key ingredients

The actives, UV filters and benefit-carrying ingredients in this formula, in the order they are listed.

Tranexamic Acid

2nd on the list, which puts it at an estimated 5–20% of the formula.

Cyclohexanecarboxylic acid, 4-(aminomethyl)-, trans-

Dark Spot Fading Evens Skin Tone Anti-Aging
Glutathione

4th on the list, which puts it at an estimated 2–10% of the formula.

Glycine, N-(N-L-.gamma.-glutamyl-L-cysteinyl)-

Anti-Aging
Niacinamide Vitamin B3 (niacinamide)

5th on the list, which puts it at an estimated 2–10% of the formula.

Niacinamide (vitamin B3) is a gentle skincare active that repairs the skin barrier, calms redness, controls oil and evens tone at 2–5%. Official IUPAC name: **3-Pyridinecarboxamide**

Soothing Anti-Aging Pore Minimizer
Hydroxyacetophenone

8th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Ethanone, 1-(4-hydroxyphenyl)-,p-Hydroxyacetophenone

Anti-Aging Hydration
Ethylhexylglycerin

10th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

1,2-Propanediol, 3-(2-ethylhexyloxy)

Hydration
Ascorbic Acid Vitamin C

12th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Ascorbic acid

Anti-Aging Dark Spot Fading Evens Skin Tone
Bisabolol

13th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

(R*,R*)-.alpha.,4-dimethyl-.alpha.-(4-methyl-3-pentenyl)cyclohex-3-ene-1-methanol; 3-Cyclohexene-1-methanol, alpha,4-dimethyl-alpha-(4-methyl-3-pentenyl)-, (theta,theta)-(+/-)-; 3-Cyclohexene-1-methanol, alpha,4-dimethyl-alpha-(4-methyl-3-pentenyl)-, (S-(theta,theta))- (levomenol)

Soothing Anti-Aging
Panthenol Vitamin B5 (panthenol)

14th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (2R)-; dl-Panthenol

Hydration Soothing
Tocopherol

15th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ol; .alpha.-tocopherol; Vitamin E

Anti-Aging Evens Skin Tone Soothing
Thioctic Acid

16th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

1,2-Dithiolane-3-pentanoic acid, (+/-)-

Anti-Aging
Glycerin

17th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Glycerine ;Glycerol (INN); Glycerol (RIFM); Glycerolum (EP); Glycyl Alcohol; 1,2,3-Propanetriol; 1,2,3-Trihydroxypropane

Hydration Anti-Aging
Water

18th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Aqua (EU),Deionized Water,Distilled Water,Micromatrix Fractile AN,Onsen-Sui (JPN),Purified Water

Hydration

Formula analysis

Each axis is scored from the ingredients present and how high up the list they sit.

Hydration Moderate

Ingredients that pull and hold water in the upper layers of skin

Barrier support Moderate

Lipids and repair signals that support skin barrier integrity

Antioxidant support Moderate

Ingredients that mop up free radicals from UV and pollution

Oil control Low

Ingredients that moderate sebum or absorb shine

Brightening Moderate

Ingredients that act on uneven tone and post-inflammatory marks

Soothing Moderate

Ingredients aimed at visible redness and reactivity

Cell renewal None

Retinoids, acids and enzymes that speed surface turnover

Firmness signalling None

Peptides and growth factors that signal for collagen support

Active and supporting ingredients

"Active" here means an ingredient carrying a recorded active type or a recognised UV filter.

Active ingredients (3)

Supporting ingredients (20)

Solvents, emollients, texture agents and preservatives — the formula that carries the actives.

Hippophae Rhamnoides Water Tranexamic Acid Tripropylene Glycol Glutathione 1,2-hexanediol Diethoxyethyl Succinate Hydroxyacetophenone Hydroxyethylcellulose Ethylhexylglycerin Disodium Edta Bisabolol Tocopherol Thioctic Acid Glycerin Water Cyanocobalamin Butylene Glycol Caprylic/capric Triglyceride Polyglyceryl-3 Methylglucose Distearate Ubiquinone

What is and is not in it

Read from the full ingredient list. A brand's own claim may differ.

Free from

  • Fragrance-free
  • Essential-oil-free
  • No drying alcohol
  • Paraben-free
  • Silicone-free
  • Microplastic-free
  • Sulfate-free
  • Dye-free
  • Oil-free
  • No animal-derived ingredients

What to layer it with

Judged by the same curated rules our routine checker uses. It reads the ingredients, not the label.

Compatible with

  • Vitamin C (L-ascorbic acid)
  • PHAs (gluconolactone)
  • Azelaic acid
  • Copper peptides
  • Bakuchiol
  • Niacinamide
  • Hyaluronic acid
  • Ceramides
  • Signal peptides
  • Panthenol
  • Sunscreen

Use with caution

  • Benzoyl peroxide

    Best kept to separate routines — one in the morning, one at night, or on alternate days.

  • Retinoids (retinol, retinal)

    Can be layered, but the combination raises the irritation risk. Go slowly.

  • AHAs (glycolic, lactic)

    Can be layered, but the combination raises the irritation risk. Go slowly.

  • BHA (salicylic acid)

    Can be layered, but the combination raises the irritation risk. Go slowly.

Where it fits in a routine

Morning Evening
  1. Cleanse
  2. Toning
  3. Treat
  4. Moisturise
  5. Protect

This product is the "Treat" step.

  • Apply to clean, dry skin and give it a minute to absorb before the next layer.
  • Introduce one new treatment at a time so you can identify what is working.

Safety and suitability

Flags to check, not verdicts. None of this is medical advice — if you are pregnant, breastfeeding or treating a skin condition, ask a doctor.

Pregnancy and breastfeeding
Nothing in this formula is on the standard pregnancy-caution list. That is not clearance — ask your doctor about anything you use daily.
Fungal acne (malassezia)
1 ingredient could feed malassezia: Polyglyceryl-3 Methylglucose Distearate. That is about the yeast's food supply, not a prediction that you will break out.
Sensitive and reactive skin
No ingredient in this formula carries a common-irritant flag, making it a reasonable option for reactive skin. A patch test is still recommended, as individual skin reactivity varies.

Ingredients by function

Most ingredients do more than one job, so these counts add up to more than the 23 ingredients on the label.

6
Antioxidant

Neutralises free radicals from UV and pollution

5
Solvent

Dissolves and carries everything else

5
Texture agent

Sets the thickness, spread and stability of the formula

3
Active

Changes how skin behaves rather than how it feels

3
Humectant

Draws water into the upper layers of skin

2
Occlusive

Forms a film that slows water loss

1
Soothing

Calms visible redness and irritation

1
Chelator

Binds trace metals that would otherwise spoil the formula

1
pH adjuster

Sets the acidity the formula needs to work

1
Surfactant

Lifts oil and dirt, or holds oil and water together

Ingredient breakdown

Every ingredient on the label, in order, with what it does and roughly how much of it is likely to be there.

1 Hippophae Rhamnoides Water
Estimated level
30–80%
Confidence
Moderate — INCI order above the 1% line

1st on the list, which puts it at an estimated 30–80% of the formula.

Hippophae Rhamnoides Water is the aqueous solution of the steam distillates obtained from the whole plant of the Sea Buckthorn, Hippophae rhmanoides L, Elagnaceae

2 Tranexamic Acid
Estimated level
5–20%
Confidence
Moderate — INCI order above the 1% line

2nd on the list, which puts it at an estimated 5–20% of the formula.

Cyclohexanecarboxylic acid, 4-(aminomethyl)-, trans-

Dark Spot Fading Evens Skin Tone Anti-Aging
8 scientific references
  • Journal of Cosmetic Dermatology, February 2021, pages 561-565
  • International Journal of Medical Sciences, March 2020, pages 903-911
  • Journal of Cosmetic Dermatology, April 2019, pages 563-567
  • Journal of Cutaneous and Aesthetic Surgery, January-March 2019, pages 63-67; and July-August 2013, pages 139-143
  • BioMed Research International, November 2018, ePublication
  • Dermatologic Surgery, June 2018, pages 814-825
  • Dermatology and Therapy, September 2017, pages 417-424
  • Journal of Research in Medical Sciences, August 2014, pages 753-757
3 Tripropylene Glycol Humectant
Estimated level
5–20%
Confidence
Moderate — INCI order above the 1% line
Roles
Humectant, Antioxidant, Texture agent

3rd on the list, which puts it at an estimated 5–20% of the formula.

Propanol, [(1-methyl-1,2-ethanediyl)bis(oxy)]bis-

4 Glutathione
Estimated level
2–10%
Confidence
Moderate — INCI order above the 1% line

4th on the list, which puts it at an estimated 2–10% of the formula.

Glycine, N-(N-L-.gamma.-glutamyl-L-cysteinyl)-

Anti-Aging
8 scientific references
  • Journal of Cosmetic Dermatology, June 2019, pages 728–737
  • Clinical Cosmetic and Investigative Dermatology, April 2017, pages 147-153 and October 2014, pages 267-274
  • Nutrients, August 2017, pages 1-27
  • DermatoEndocrinology, July 2012, pages 308-319
  • Journal of Agricultural and Food Chemistry, 2011, pages 3, 940-3, 949
  • The Dermatologist, October 2011, volume 19, issue 10
  • Journal of Dermatologic Science, May 2010, pages 85-90
  • Free Radical Biology and Medicine, October 1994, pages 333-349
5 Niacinamide Active
Estimated level
2–10%
Confidence
Moderate — INCI order above the 1% line
Roles
Active

5th on the list, which puts it at an estimated 2–10% of the formula.

Niacinamide (vitamin B3) is a gentle skincare active that repairs the skin barrier, calms redness, controls oil and evens tone at 2–5%. Official IUPAC name: **3-Pyridinecarboxamide**

Soothing Anti-Aging Pore Minimizer
15 scientific references
  • International Journal of Dermatology, February 2021, pages 166-173
  • Biomolecules & Therapeutics, July 2019, pages 562-569
  • Experimental Dermatology, February 2019, pages 15-22
  • Dermatologic Therapy, September 2017, ePublication
  • Journal of Investigative Dermatology, May 2017, page S116
  • International Journal of Pharmaceutics, March 2017, pages 158-162
  • Facial Plastic Surgery Clinics of North America, May 2016, pages 145-152
  • Clinical, Cosmetic, and Investigational Dermatology, July 2015, pages 405-412
  • Skin Pharmacology and Physiology, June 2014, pages 311-315
  • International Journal of Pharmacy, January 2013, pages 192-201
  • Dermatoendrocrinology, July 2012, pages 308-319
  • International Journal of Toxicology, September 2005, pages 1-31
  • Dermatologic Surgery, July 2005, pages 860-865
  • International Journal of Cosmetic Science, October 2004, pages 231-238
  • Journal of Cosmetic Dermatology, April 2004, pages 88-93
6 1,2-hexanediol Solvent
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Solvent

6th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

7 Diethoxyethyl Succinate Solvent
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Solvent

7th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Butanedioic acid, bis(2-ethoxyethyl) ester

8 Hydroxyacetophenone Antioxidant
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Antioxidant

8th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Ethanone, 1-(4-hydroxyphenyl)-,p-Hydroxyacetophenone

Anti-Aging Hydration
4 scientific references
  • Journal of Oleo Science, February 2019, pages 183-191
  • Applied Environmental Microbiology, June 2018, ePublication
  • Journal of Biosciences, May-June 2004, pages 345-353
  • Scientific Reports, April 2021, pages 1–7
9 Hydroxyethylcellulose Occlusive
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Occlusive, Texture agent

9th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Cellulose, 2-hydroxyethyl ether

10 Ethylhexylglycerin
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

10th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

1,2-Propanediol, 3-(2-ethylhexyloxy)

Hydration
5 scientific references
  • PLoS One, October 2016, ePublication
  • Contact Dermatitis, May 2016, pages 281-288
  • International Journal of Toxicology, September 2013, pages 5S-21S
  • Personal Care, 2008, pages 1-4
  • Cosmetic Science Technology, 2006, pages 1-11
11 Disodium Edta Texture agent
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Texture agent, Chelator

11th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Disodium dihydrogen ethylenediaminetetraacetate

12 Ascorbic Acid Active
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Active, Antioxidant, pH adjuster

12th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Ascorbic acid

Anti-Aging Dark Spot Fading Evens Skin Tone
12 scientific references
  • Drug Delivery, February 2021, pages 445-453
  • Journal of Cosmetic Dermatology, December 2020, pages 3, 262-3, 269
  • Journal of Oral and Maxillofacial Pathology, May-August 2020, pages 374-382
  • Journal of Cosmetic Dermatology, March 2020, pages 671-676
  • Journal of Clinical and Aesthetic Dermatology, July 2017 pages 14-17
  • Journal of Drugs in Dermatology, July 2016, pages 863-867
  • Clinical, Cosmetic, and Investigational Dermatology, September 2015, pages 463-470
  • Indian Dermatology Online Journal, April-June 2013, pages 143-146
  • AAPS PharmSciTech, July 2011, pages 917-923
  • Journal of Drugs in Dermatology, July 2008, Supplement, pages s2-s6
  • International Journal of Toxicology, Supplement 2, March 2005, pages 51-111
  • Skin Pharmacology and Physiology, July-August 2004, pages 200-206
13 Bisabolol Soothing
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Soothing

13th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

(R*,R*)-.alpha.,4-dimethyl-.alpha.-(4-methyl-3-pentenyl)cyclohex-3-ene-1-methanol; 3-Cyclohexene-1-methanol, alpha,4-dimethyl-alpha-(4-methyl-3-pentenyl)-, (theta,theta)-(+/-)-; 3-Cyclohexene-1-methanol, alpha,4-dimethyl-alpha-(4-methyl-3-pentenyl)-, (S-(theta,theta))- (levomenol)

Soothing Anti-Aging
6 scientific references
  • CosmeticsInfoorg, Accessed May 2021, ePublication
  • International Journal of Cosmetic Science, August 2019, pages 299-303
  • International Journal of Toxicology, September 2017, pages 24S-25S
  • Cutis, November 2015, pages 337-342
  • Current Pharmaceutical Biotechnology, 2014, pages 173-181
  • Food and Chemical Toxicology, October 2011, pages 2580-2585
14 Panthenol Active
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Active

14th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (2R)-; dl-Panthenol

Hydration Soothing
7 scientific references
  • The Linus Pauling Institute, Oregon State University, Accessed April 2021, ePublication
  • International Journal of Cosmetic Science, December 2019, pages 534-547
  • Journal of Cosmetic Dermatology, January 2019, pages 346-354
  • Cosmetic Ingredient Review, March 2018, pages 1-51
  • The Journal of Dermatological Treatment, August 2017, pages 173-180
  • Journal of Cosmetic Science, August 2011, pages 361-370
  • American Journal of Clinical Dermatology, Volume 3, 2002, pages 427-433
15 Tocopherol Antioxidant
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Antioxidant

15th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ol; .alpha.-tocopherol; Vitamin E

Anti-Aging Evens Skin Tone Soothing
4 scientific references
  • Journal or Agricultural and Food Chemistry, June 2010, pages 7013-7020
  • Journal of Investigative Dermatology, November 2001, pages 1212-1217
  • Canadian Family Physician, July 2006, pages 855-856
  • Dermatologic Surgery, April 1999, pages 311-315
16 Thioctic Acid Antioxidant
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Antioxidant

16th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

1,2-Dithiolane-3-pentanoic acid, (+/-)-

Anti-Aging
17 Glycerin Humectant
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Humectant, Occlusive, Texture agent, Solvent

17th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Glycerine ;Glycerol (INN); Glycerol (RIFM); Glycerolum (EP); Glycyl Alcohol; 1,2,3-Propanetriol; 1,2,3-Trihydroxypropane

Hydration Anti-Aging
6 scientific references
  • Journal of Pharmaceutical Investigation, March 2021, pages 223-231
  • International Journal of Toxicology, November/December 2019, Volume 38, Supplement 3, pages 6S-22S
  • International Journal of Cosmetic Science, August 2016, ePublication
  • British Journal of Dermatology, July 2008, pages 23-34
  • Journal of Cosmetic Dermatology, June 2007, pages 75-82
  • Proceedings of the National Academy of Sciences, June 2003, pages 7, 360-7, 365
18 Water Solvent
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Solvent

18th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Aqua (EU),Deionized Water,Distilled Water,Micromatrix Fractile AN,Onsen-Sui (JPN),Purified Water

Hydration
3 scientific references
  • Skin Research and Technology, May 2015, pages 131-136
  • Skin Pharmacology and Applied Skin Physiology, November-December 1999, pages 344-351
  • Journal of Cosmetic Science, September-October 1993, pages 249-262
19 Cyanocobalamin
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

19th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Cyanocobalamin; Vitamine B12

Anti-Aging
8 scientific references
  • 5 Super Anti-Aging Antioxidants Your Skin Needs
  • How to Keep Your Neck & Chest Looking Young
  • Acne & Aging Skin
  • How to Diminish Uneven Skin Tone and Get Your Glow Back
  • What Are Peptides and What Do They Do for Skin?
  • The Truth About Firming Creams
  • Top 5 Reasons to Add Antioxidants to Your Skin Care Routine
  • Anti-Aging Superstars
20 Butylene Glycol Humectant
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Humectant, Texture agent, Solvent

20th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Butane-1,3-diol (CAS No. 107-88-0/ EC No. 203-529-7) (R)-(-)-butane-1,3-diol” (CAS No. 6290-03-5/ EC No. 228-532-0)

Hydration
5 scientific references
  • CosmeticsInfoorg, Accessed March 2021, ePublication
  • US Food and Drug Administration Code of Federal Regulations</em>, Accessed March 2021, ePublication
  • International Journal of Toxicology, May 2011, pages 5S-16S
  • Skin Research and Technology, November 2007, pages 417-24
  • Journal of the American College of Toxicology, September 1985, pages 223-248
21 Caprylic/capric Triglyceride
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

21st on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Decanoic acid, ester with 1,2,3-propanetriol octanoate; Glycerides, mixed decanoyl and octanoyl

Hydration
5 scientific references
  • International Journal of Toxicology, September 2020, pages 34-35
  • Periodica Polytechnica Chemical Engineering, 2014, pages 43-48
  • International Journal of Toxicology, January 2003, pages 4-5
  • Food and Chemical Toxicology, January 2000, pages 79-98
  • Journal of the Society of Cosmetic Chemists, August 1985, pages 303-311
22 Polyglyceryl-3 Methylglucose Distearate Surfactant
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Surfactant

22nd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Methyl-D-glucopyranoside, ethers with 1,2,3-propanetriol homopolymer, octadecanoates (1:1:2) (3 mol glycerol average molar ratio)

23 Ubiquinone Antioxidant
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Antioxidant

23rd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

2,5-Cyclohexadiene-1,4-dione, 2-(3,7,11,15,19,23,27,31,35,39-decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaenyl)-5,6-dimethoxy-3-methyl-, (all-E)-

Anti-Aging Soothing
6 scientific references
  • Free Radical Biology and Medicine, March 2021, pages 282-288
  • Biofactors, November-December 2015, pages 383-390; 2008, pages 245-255; and 2005, pages 179-185
  • Journal of Cosmetic Dermatology, March 2006, issue 1, pages 30-38
  • Journal of Investigative Dermatology, 2005, issue 4, pages 12-13
  • Journal of Dermatological Science, August 2001, Supplement, pages 1-4
  • https://wwwcir-safetyorg/sites/default/files/Ubiquinonepdf

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Frequently asked questions

What ingredients are in No.5 Glutathione TXA Advanced Dark Spot Ampoule Concentrate?

HIPPOPHAE RHAMNOIDES WATER, TRANEXAMIC ACID, TRIPROPYLENE GLYCOL, GLUTATHIONE, NIACINAMIDE, 1,2-HEXANEDIOL, DIETHOXYETHYL SUCCINATE, HYDROXYACETOPHENONE, HYDROXYETHYLCELLULOSE, ETHYLHEXYLGLYCERIN, DISODIUM EDTA, ASCORBIC ACID, BISABOLOL, PANTHENOL, TOCOPHEROL, THIOCTIC ACID, GLYCERIN, WATER, CYANOCOBALAMIN, BUTYLENE GLYCOL, CAPRYLIC/CAPRIC TRIGLYCERIDE, POLYGLYCERYL-3 METHYLGLUCOSE DISTEARATE, UBIQUINONE.

What are the active ingredients in No.5 Glutathione TXA Advanced Dark Spot Ampoule Concentrate?

NIACINAMIDE, ASCORBIC ACID, PANTHENOL.

How do I use No.5 Glutathione TXA Advanced Dark Spot Ampoule Concentrate?

The product features a push top that you use to release one ingredient into the other to activate them. Do not combine until you are ready to use. It is recommended to use the formula within 2 weeks of activation.

What skin types is No.5 Glutathione TXA Advanced Dark Spot Ampoule Concentrate good for?

Judged on how rich the formula reads from its ingredient list, it suits Balanced, Combination (oily), Oily skin best. It is the least natural fit for Dry, Combination (dry) skin.

Is No.5 Glutathione TXA Advanced Dark Spot Ampoule Concentrate good for sensitive skin?

No ingredient in this formula carries a common-irritant flag, making it a reasonable option for reactive skin. A patch test is still recommended, as individual skin reactivity varies.

Is No.5 Glutathione TXA Advanced Dark Spot Ampoule Concentrate fungal acne safe?

One ingredient could feed malassezia: Polyglyceryl-3 Methylglucose Distearate. That describes the yeast's food supply, not a prediction that it will cause a breakout.

Can I use No.5 Glutathione TXA Advanced Dark Spot Ampoule Concentrate while pregnant?

Nothing in this formula is on the standard pregnancy-caution list. That is not medical clearance — check anything you use daily with your doctor or midwife.

Is No.5 Glutathione TXA Advanced Dark Spot Ampoule Concentrate fragrance free?

Yes. Reading the full ingredient list, this formula is fragrance-free.

Does No.5 Glutathione TXA Advanced Dark Spot Ampoule Concentrate contain alcohol?

No. Reading the full ingredient list, this formula is no drying alcohol.

Is No.5 Glutathione TXA Advanced Dark Spot Ampoule Concentrate silicone free?

Yes. Reading the full ingredient list, this formula is silicone-free.

Does No.5 Glutathione TXA Advanced Dark Spot Ampoule Concentrate contain essential oils?

No. Reading the full ingredient list, this formula is essential-oil-free.

Is No.5 Glutathione TXA Advanced Dark Spot Ampoule Concentrate paraben free?

Yes. Reading the full ingredient list, this formula is paraben-free.

What can I layer with No.5 Glutathione TXA Advanced Dark Spot Ampoule Concentrate?

It layers well with Vitamin C (L-ascorbic acid), PHAs (gluconolactone), Azelaic acid, Copper peptides, Bakuchiol, Niacinamide. Take more care combining it with Benzoyl peroxide, Retinoids (retinol, retinal), AHAs (glycolic, lactic), BHA (salicylic acid) — use them in separate routines or on alternate days.

When should I apply No.5 Glutathione TXA Advanced Dark Spot Ampoule Concentrate?

Use it morning and evening, after toner, before moisturiser.

How many ingredients does No.5 Glutathione TXA Advanced Dark Spot Ampoule Concentrate have?

It lists 23 ingredients, of which 3 are recorded as actives.

Who makes No.5 Glutathione TXA Advanced Dark Spot Ampoule Concentrate?

Numbuzin, a brand based in Korean.

Brand
Numbuzin
Country
Korean
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