Dr. Reju-All Advanced Retino-Mela Serum

Dr. Reju-All

Advanced Retino-Mela Serum

face serum

Added Last edited

Fit by skin type

General, ingredient-based — not your personalized match.

Dry
59%
Combination (dry)
59%
Balanced
89%
Combination (oily)
81%
Oily
81%

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38
Ingredients
7
Benefits
4
Actives
Find Dupes

The Dr. Reju-All Advanced Retino-Mela Serum is a high-performance treatment designed to target hyperpigmentation, uneven skin tone, and early signs of aging. Formulated with a potent combination of retinoid and melanin-correcting ingredients, this serum helps accelerate cell turnover while reducing the appearance of dark spots and discoloration. Its lightweight, fast-absorbing texture delivers powerful results while remaining comfortable on the skin. Balanced with soothing and barrier-supporting ingredients, the Dr. Reju-All Advanced Retino-Mela Serum helps minimize irritation often associated with retinoids. With consistent use, it improves skin clarity, refines texture, and promotes a brighter, smoother, and more even complexion.

Key Insights

Benefits

7
Anti-Acne
Anti-Aging
Dark Spot Fading
Evens Skin Tone
Hydration
Pore Minimizer
Soothing

Active Ingredients

4
Hyaluronic acid Retinoids Vitamin B3 (niacinamide) Vitamin B5 (panthenol)

Risks

2
Silicone
Synthetic polymer

About Advanced Retino-Mela Serum

Overview

Advanced Retino-Mela Serum is a lightweight serum from Dr. Reju-All, a brand based in Korea. The formula is built mainly around hydration. The ingredient list runs to 38 ingredients, each broken down in full below.

Texture and finish

By its ingredient list the formula reads as light: water and humectants lead, with emollients kept lower in the order. Silicones in the formula tend to give a smooth, blurred finish and help it grip under makeup. Hydration is handled by Butylene Glycol, Glycerin and Betaine, humectants that pull water into the upper layers of skin rather than sealing it there.

What the formula does

Hydration: High. Ingredients that pull and hold water in the upper layers of skin, and here that comes from Butylene Glycol, Glycerin, Betaine and Propanediol.

Barrier support: Moderate. Lipids and repair signals that support skin barrier integrity, and here that comes from Niacinamide, Squalane and Panthenol.

Brightening: Moderate. Ingredients that act on uneven tone and post-inflammatory marks, and here that comes from Niacinamide, Tranexamic Acid, Hydroxypinacolone Retinoate and Tocopherol.

Soothing: Moderate. Ingredients aimed at visible redness and reactivity, and here that comes from Bisabolol, Panthenol, Hydroxypinacolone Retinoate and Beta-glucan.

Who it suits

On richness alone it suits Balanced, Combination (oily) and Oily skin best, and is the least natural fit for Dry and Combination (dry) skin. Nothing in the list is flagged as a common irritant, which is a reasonable starting point for reactive skin — though a patch test is still the only way to know.

What it does not target

The formula contributes little or nothing on antioxidant protection, cell renewal and firmness signalling. That is not a fault — most products are not meant to do everything — but if one of those is your priority, this is not the product that will address it.

What is not in it

Reading the full list, the formula is fragrance-free, essential-oil-free, no drying alcohol, paraben-free, microplastic-free and sulfate-free. Those claims come from the ingredient list itself, not from the packaging.

Where it fits in a routine

It can be used morning and evening. In a routine it goes after toner, before moisturiser. Apply to clean, dry skin and give it a minute to absorb before the next layer. Introduce one new treatment at a time so you can identify what is working.

This summary is generated from the product's ingredient list. It is not a review, it is not the brand's own marketing claims, and it does not replace advice from a dermatologist.

Pros and cons

Drawn purely from the ingredient list

Pros

  • No fragrance or declared allergens
  • No essential oils
  • No drying alcohol
  • No microplastics
  • Strong humectant content for hydration
  • No common irritants flagged in the list

Things to know

  • 4 ingredients could feed malassezia (fungal acne)
  • Contains ingredients usually flagged for review during pregnancy

Which skin types it suits

Scored on how rich or light the formula reads from its INCI order.

Suitable for

  • Balanced skin
  • Combination (oily) skin
  • Oily skin

Less suitable for

  • Dry skin
  • Combination (dry) skin

Sensitive skin

No ingredient in this formula carries a common-irritant flag, making it a reasonable option for reactive skin. A patch test is still recommended, as individual skin reactivity varies.

Skin concerns

Based on the curated benefits documented for this product's ingredients.

Helps with

  • Hydration 14 ingredients

    Attracts and locks in moisture to keep skin plump and dewy

  • Anti-Aging 9 ingredients

    Boosts collagen and cell turnover to reduce fine lines and wrinkles

  • Soothing 8 ingredients

    Calms redness, irritation, and inflammation for sensitive skin

  • Evens Skin Tone 3 ingredients

    Brightens and balances complexion for a more uniform appearance

  • Anti-Acne 1 ingredient

    Targets breakouts by reducing bacteria and unclogging pores

  • Dark Spot Fading 1 ingredient

    Fades hyperpigmentation and evens out dark spots over time

  • Pore Minimizer 1 ingredient

    Tightens and refines the look of enlarged pores

Does not target

Blackhead Reducing Oil Control Smooths Bumpy Skin

None of the ingredients in this formula are associated with these benefits. This is not unusual, as most products are designed to target a limited number of concerns.

Key ingredients

The actives, UV filters and benefit-carrying ingredients in this formula, in the order they are listed.

1st on the list, which puts it at an estimated 30–80% of the formula.

Aqua (EU),Deionized Water,Distilled Water,Micromatrix Fractile AN,Onsen-Sui (JPN),Purified Water

Hydration

2nd on the list, which puts it at an estimated 5–20% of the formula.

Butane-1,3-diol (CAS No. 107-88-0/ EC No. 203-529-7) (R)-(-)-butane-1,3-diol” (CAS No. 6290-03-5/ EC No. 228-532-0)

Hydration
Niacinamide Vitamin B3 (niacinamide)

3rd on the list, which puts it at an estimated 5–20% of the formula.

Niacinamide (vitamin B3) is a gentle skincare active that repairs the skin barrier, calms redness, controls oil and evens tone at 2–5%. Official IUPAC name: **3-Pyridinecarboxamide**

Soothing Anti-Aging Pore Minimizer

4th on the list, which puts it at an estimated 2–10% of the formula.

2,6,10,15,19,23-Hexamethyltetracosane

Hydration Anti-Aging

5th on the list, which puts it at an estimated 2–10% of the formula.

Cyclohexanecarboxylic acid, 4-(aminomethyl)-, trans-

Dark Spot Fading Evens Skin Tone Anti-Aging

6th on the list, which puts it at an estimated 2–10% of the formula.

1,1,1,3,5,5,5-Heptamethyl-3-(trimethylsilyloxy)trisiloxane

Hydration

7th on the list, which puts it at an estimated 1–5% of the formula.

1,2-Dihydroxypentane

Hydration

8th on the list, which puts it at an estimated 1–5% of the formula.

Glycerine ;Glycerol (INN); Glycerol (RIFM); Glycerolum (EP); Glycyl Alcohol; 1,2,3-Propanetriol; 1,2,3-Trihydroxypropane

Hydration Anti-Aging

10th on the list, which puts it at an estimated 1–5% of the formula.

Methanaminium, 1-carboxy-N,N,N-trimethyl-, hydroxide, inner salt

Hydration

11th on the list, which puts it at an estimated 1–3% of the formula.

1,3-dihydroxypropane

Hydration

14th on the list, which puts it at an estimated 1–3% of the formula.

(R*,R*)-.alpha.,4-dimethyl-.alpha.-(4-methyl-3-pentenyl)cyclohex-3-ene-1-methanol; 3-Cyclohexene-1-methanol, alpha,4-dimethyl-alpha-(4-methyl-3-pentenyl)-, (theta,theta)-(+/-)-; 3-Cyclohexene-1-methanol, alpha,4-dimethyl-alpha-(4-methyl-3-pentenyl)-, (S-(theta,theta))- (levomenol)

Soothing Anti-Aging
Panthenol Vitamin B5 (panthenol)

15th on the list, which puts it at an estimated 1–3% of the formula.

Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (2R)-; dl-Panthenol

Hydration Soothing

Formula analysis

Each axis is scored from the ingredients present and how high up the list they sit.

Hydration High

Ingredients that pull and hold water in the upper layers of skin

Barrier support Moderate

Lipids and repair signals that support skin barrier integrity

Antioxidant support None

Ingredients that mop up free radicals from UV and pollution

Oil control Moderate

Ingredients that moderate sebum or absorb shine

Brightening Moderate

Ingredients that act on uneven tone and post-inflammatory marks

Soothing Moderate

Ingredients aimed at visible redness and reactivity

Cell renewal None

Retinoids, acids and enzymes that speed surface turnover

Firmness signalling None

Peptides and growth factors that signal for collagen support

Active and supporting ingredients

"Active" here means an ingredient carrying a recorded active type or a recognised UV filter.

Active ingredients (4)

Supporting ingredients (34)

Solvents, emollients, texture agents and preservatives — the formula that carries the actives.

Water Butylene Glycol Squalane Tranexamic Acid Methyl Trimethicone Pentylene Glycol Glycerin Hydrogenated Ethylhexyl Olivate Betaine Propanediol Dimethyl Isosorbide C14-22 Alcohols Bisabolol Tocopheryl Acetate 4-t-butylcyclohexanol Chondrus Crispus Extract Hydroxyethyl Acrylate/sodium Acryloyldimethyl Taurate Copolymer Glyceryl Stearate Peg-100 Stearate Hydrogenated Olive Oil Unsaponifiables Saccharum Officinarum Extract C12-20 Alkyl Glucoside 1,2-hexanediol Carbomer Tromethamine Ethylhexylglycerin Xanthan Gum Adenosine Palmitic Acid Stearic Acid Sorbitan Isostearate Paeonia Suffruticosa Root Extract Beta-glucan Tocopherol

What is and is not in it

Read from the full ingredient list. A brand's own claim may differ.

Free from

  • Fragrance-free
  • Essential-oil-free
  • No drying alcohol
  • Paraben-free
  • Microplastic-free
  • Sulfate-free
  • Dye-free
  • Oil-free
  • No animal-derived ingredients

Contains

  • Silicones

    Methyl Trimethicone

What to layer it with

Judged by the same curated rules our routine checker uses. It reads the ingredients, not the label.

Compatible with

  • Retinoids (retinol, retinal)
  • Copper peptides
  • Bakuchiol
  • Niacinamide
  • Hyaluronic acid
  • Ceramides
  • Signal peptides
  • Panthenol
  • Sunscreen

Use with caution

  • AHAs (glycolic, lactic)

    Best kept to separate routines — one in the morning, one at night, or on alternate days.

  • BHA (salicylic acid)

    Best kept to separate routines — one in the morning, one at night, or on alternate days.

  • PHAs (gluconolactone)

    Best kept to separate routines — one in the morning, one at night, or on alternate days.

  • Benzoyl peroxide

    Best kept to separate routines — one in the morning, one at night, or on alternate days.

  • Vitamin C (L-ascorbic acid)

    Can be layered, but the combination raises the irritation risk. Go slowly.

  • Azelaic acid

    Can be layered, but the combination raises the irritation risk. Go slowly.

Where it fits in a routine

Morning Evening
  1. Cleanse
  2. Toning
  3. Treat
  4. Moisturise
  5. Protect

This product is the "Treat" step.

  • Apply to clean, dry skin and give it a minute to absorb before the next layer.
  • Introduce one new treatment at a time so you can identify what is working.

Safety and suitability

Flags to check, not verdicts. None of this is medical advice — if you are pregnant, breastfeeding or treating a skin condition, ask a doctor.

Pregnancy and breastfeeding
Contains Hydroxypinacolone Retinoate, usually reviewed with a doctor during pregnancy.
Fungal acne (malassezia)
4 ingredients could feed malassezia: Hydrogenated Ethylhexyl Olivate, Glyceryl Stearate, Peg-100 Stearate, Sorbitan Isostearate. That is about the yeast's food supply, not a prediction that you will break out.
Sensitive and reactive skin
No ingredient in this formula carries a common-irritant flag, making it a reasonable option for reactive skin. A patch test is still recommended, as individual skin reactivity varies.
Recorded ingredient risks
Silicone, Synthetic polymer

Ingredients by function

Most ingredients do more than one job, so these counts add up to more than the 38 ingredients on the label.

11
Texture agent

Sets the thickness, spread and stability of the formula

8
Solvent

Dissolves and carries everything else

7
Surfactant

Lifts oil and dirt, or holds oil and water together

6
Emollient

Softens and smooths by filling gaps between skin cells

5
Humectant

Draws water into the upper layers of skin

4
Active

Changes how skin behaves rather than how it feels

3
Plant extract

Botanical material, usually for antioxidants or scent

2
Antioxidant

Neutralises free radicals from UV and pollution

2
Occlusive

Forms a film that slows water loss

1
Soothing

Calms visible redness and irritation

1
pH adjuster

Sets the acidity the formula needs to work

Ingredient breakdown

Every ingredient on the label, in order, with what it does and roughly how much of it is likely to be there.

1 Water Solvent
Estimated level
30–80%
Confidence
Moderate — INCI order above the 1% line
Roles
Solvent

1st on the list, which puts it at an estimated 30–80% of the formula.

Aqua (EU),Deionized Water,Distilled Water,Micromatrix Fractile AN,Onsen-Sui (JPN),Purified Water

Hydration
3 scientific references
  • Skin Research and Technology, May 2015, pages 131-136
  • Skin Pharmacology and Applied Skin Physiology, November-December 1999, pages 344-351
  • Journal of Cosmetic Science, September-October 1993, pages 249-262
2 Butylene Glycol Humectant
Estimated level
5–20%
Confidence
Moderate — INCI order above the 1% line
Roles
Humectant, Texture agent, Solvent

2nd on the list, which puts it at an estimated 5–20% of the formula.

Butane-1,3-diol (CAS No. 107-88-0/ EC No. 203-529-7) (R)-(-)-butane-1,3-diol” (CAS No. 6290-03-5/ EC No. 228-532-0)

Hydration
5 scientific references
  • CosmeticsInfoorg, Accessed March 2021, ePublication
  • US Food and Drug Administration Code of Federal Regulations</em>, Accessed March 2021, ePublication
  • International Journal of Toxicology, May 2011, pages 5S-16S
  • Skin Research and Technology, November 2007, pages 417-24
  • Journal of the American College of Toxicology, September 1985, pages 223-248
3 Niacinamide Active
Estimated level
5–20%
Confidence
Moderate — INCI order above the 1% line
Roles
Active

3rd on the list, which puts it at an estimated 5–20% of the formula.

Niacinamide (vitamin B3) is a gentle skincare active that repairs the skin barrier, calms redness, controls oil and evens tone at 2–5%. Official IUPAC name: **3-Pyridinecarboxamide**

Soothing Anti-Aging Pore Minimizer
15 scientific references
  • International Journal of Dermatology, February 2021, pages 166-173
  • Biomolecules & Therapeutics, July 2019, pages 562-569
  • Experimental Dermatology, February 2019, pages 15-22
  • Dermatologic Therapy, September 2017, ePublication
  • Journal of Investigative Dermatology, May 2017, page S116
  • International Journal of Pharmaceutics, March 2017, pages 158-162
  • Facial Plastic Surgery Clinics of North America, May 2016, pages 145-152
  • Clinical, Cosmetic, and Investigational Dermatology, July 2015, pages 405-412
  • Skin Pharmacology and Physiology, June 2014, pages 311-315
  • International Journal of Pharmacy, January 2013, pages 192-201
  • Dermatoendrocrinology, July 2012, pages 308-319
  • International Journal of Toxicology, September 2005, pages 1-31
  • Dermatologic Surgery, July 2005, pages 860-865
  • International Journal of Cosmetic Science, October 2004, pages 231-238
  • Journal of Cosmetic Dermatology, April 2004, pages 88-93
4 Squalane Emollient
Estimated level
2–10%
Confidence
Moderate — INCI order above the 1% line
Roles
Emollient

4th on the list, which puts it at an estimated 2–10% of the formula.

2,6,10,15,19,23-Hexamethyltetracosane

Hydration Anti-Aging
9 scientific references
  • Cosmetics Ingredient Review, 2019, ePublication
  • ACS Open, July 2017, pages 3, 989–3, 996
  • Indian Journal of Dermatology, May-June 2016, pages 279-297
  • The Journal of Clinical and Aesthetic Dermatology, June 2014, pages 25-32
  • Journal of Cosmetic Science, January-February 2013, pages 59-66
  • Advances in Food and Nutrition Research, 2012, pages 223-233
  • Molecules, January 2009, pages 540-554
  • Journal of Investigative Dermatology, November 2006, pages 2, 430-2, 437
  • Free Radical Research, April 2002, pages 471-477
Estimated level
2–10%
Confidence
Moderate — INCI order above the 1% line

5th on the list, which puts it at an estimated 2–10% of the formula.

Cyclohexanecarboxylic acid, 4-(aminomethyl)-, trans-

Dark Spot Fading Evens Skin Tone Anti-Aging
8 scientific references
  • Journal of Cosmetic Dermatology, February 2021, pages 561-565
  • International Journal of Medical Sciences, March 2020, pages 903-911
  • Journal of Cosmetic Dermatology, April 2019, pages 563-567
  • Journal of Cutaneous and Aesthetic Surgery, January-March 2019, pages 63-67; and July-August 2013, pages 139-143
  • BioMed Research International, November 2018, ePublication
  • Dermatologic Surgery, June 2018, pages 814-825
  • Dermatology and Therapy, September 2017, pages 417-424
  • Journal of Research in Medical Sciences, August 2014, pages 753-757
Estimated level
2–10%
Confidence
Moderate — INCI order above the 1% line
Roles
Solvent

6th on the list, which puts it at an estimated 2–10% of the formula.

1,1,1,3,5,5,5-Heptamethyl-3-(trimethylsilyloxy)trisiloxane

Hydration Silicone
8 scientific references
  • Supercharged Hydration
  • How Hyaluronic Acid Benefits Skin
  • What is Dehydrated Skin & How to Choose the Best Products
  • What Your Moisturizer Must Contain
  • Moisturizer Myths You Should Stop Believing Now
  • The Benefits of Glycerin in Skin Care
  • The Best Face Oils for Skin
  • How Facial Oils Help Skin
Estimated level
1–5%
Confidence
Moderate — INCI order above the 1% line
Roles
Solvent

7th on the list, which puts it at an estimated 1–5% of the formula.

1,2-Dihydroxypentane

Hydration
4 scientific references
  • https://thedermreviewcom/pentylene-glycol/
  • Regulatory Toxicology and Pharmacology, July 2017, pages 106-111
  • Prospector, June 2015, ePublication
  • International Journal of Toxicology, October 2012, pages 147S-168S
8 Glycerin Humectant
Estimated level
1–5%
Confidence
Moderate — INCI order above the 1% line
Roles
Humectant, Occlusive, Texture agent, Solvent

8th on the list, which puts it at an estimated 1–5% of the formula.

Glycerine ;Glycerol (INN); Glycerol (RIFM); Glycerolum (EP); Glycyl Alcohol; 1,2,3-Propanetriol; 1,2,3-Trihydroxypropane

Hydration Anti-Aging
6 scientific references
  • Journal of Pharmaceutical Investigation, March 2021, pages 223-231
  • International Journal of Toxicology, November/December 2019, Volume 38, Supplement 3, pages 6S-22S
  • International Journal of Cosmetic Science, August 2016, ePublication
  • British Journal of Dermatology, July 2008, pages 23-34
  • Journal of Cosmetic Dermatology, June 2007, pages 75-82
  • Proceedings of the National Academy of Sciences, June 2003, pages 7, 360-7, 365
Estimated level
1–5%
Confidence
Moderate — INCI order above the 1% line
Roles
Emollient

9th on the list, which puts it at an estimated 1–5% of the formula.

Hydrogenated Ethylhexyl Olivate is a misture of esters produced by the reaction of ethylhexanol and Hydrogenated Olive Oil

10 Betaine Humectant
Estimated level
1–5%
Confidence
Moderate — INCI order above the 1% line
Roles
Humectant, Texture agent

10th on the list, which puts it at an estimated 1–5% of the formula.

Methanaminium, 1-carboxy-N,N,N-trimethyl-, hydroxide, inner salt

Hydration
5 scientific references
  • International Journal of Toxicology, 2018, pages 28S-46S
  • Food Science and Biotechnology, October 2017, pages 1391-1397
  • The Journal of Chemical Physics, June 2015, ePublication
  • The American Journal of Clinical Nutrition, September 2004, pages 539-549
  • Skin Research and Technology, February 2003, pages 50-58
11 Propanediol Texture agent
Estimated level
1–3%
Confidence
Moderate — INCI order above the 1% line
Roles
Texture agent, Solvent

11th on the list, which puts it at an estimated 1–3% of the formula.

1,3-dihydroxypropane

Hydration
4 scientific references
  • PubChem Compound Summary, April 2021, ePublication
  • SpecialChem, Accessed April 2021, ePublication
  • Cosmetic Ingredient Review, June 2018, pages 1-73
  • Cosmetics & Toiletries, May 2013, pages 81-86
12 Dimethyl Isosorbide Texture agent
Estimated level
1–3%
Confidence
Moderate — INCI order above the 1% line
Roles
Texture agent, Solvent

12th on the list, which puts it at an estimated 1–3% of the formula.

1,4:3,6-Dianhydro-2,5-di-O-methyl-D-glucitol

13 C14-22 Alcohols Texture agent
Estimated level
1–3%
Confidence
Moderate — INCI order above the 1% line
Roles
Texture agent

13th on the list, which puts it at an estimated 1–3% of the formula.

C14-22 Alcohols is a mixture of synthetic fatty alcohols with 14 to 22 carbons in the alkyl chain

14 Bisabolol Soothing
Estimated level
1–3%
Confidence
Moderate — INCI order above the 1% line
Roles
Soothing

14th on the list, which puts it at an estimated 1–3% of the formula.

(R*,R*)-.alpha.,4-dimethyl-.alpha.-(4-methyl-3-pentenyl)cyclohex-3-ene-1-methanol; 3-Cyclohexene-1-methanol, alpha,4-dimethyl-alpha-(4-methyl-3-pentenyl)-, (theta,theta)-(+/-)-; 3-Cyclohexene-1-methanol, alpha,4-dimethyl-alpha-(4-methyl-3-pentenyl)-, (S-(theta,theta))- (levomenol)

Soothing Anti-Aging
6 scientific references
  • CosmeticsInfoorg, Accessed May 2021, ePublication
  • International Journal of Cosmetic Science, August 2019, pages 299-303
  • International Journal of Toxicology, September 2017, pages 24S-25S
  • Cutis, November 2015, pages 337-342
  • Current Pharmaceutical Biotechnology, 2014, pages 173-181
  • Food and Chemical Toxicology, October 2011, pages 2580-2585
15 Panthenol Active
Estimated level
1–3%
Confidence
Moderate — INCI order above the 1% line
Roles
Active

15th on the list, which puts it at an estimated 1–3% of the formula.

Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (2R)-; dl-Panthenol

Hydration Soothing
7 scientific references
  • The Linus Pauling Institute, Oregon State University, Accessed April 2021, ePublication
  • International Journal of Cosmetic Science, December 2019, pages 534-547
  • Journal of Cosmetic Dermatology, January 2019, pages 346-354
  • Cosmetic Ingredient Review, March 2018, pages 1-51
  • The Journal of Dermatological Treatment, August 2017, pages 173-180
  • Journal of Cosmetic Science, August 2011, pages 361-370
  • American Journal of Clinical Dermatology, Volume 3, 2002, pages 427-433
16 Tocopheryl Acetate Antioxidant
Estimated level
1–3%
Confidence
Moderate — INCI order above the 1% line
Roles
Antioxidant

16th on the list, which puts it at an estimated 1–3% of the formula.

3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-yl acetate

Anti-Aging Soothing
8 scientific references
  • 5 Super Anti-Aging Antioxidants Your Skin Needs
  • How to Keep Your Neck & Chest Looking Young
  • Acne & Aging Skin
  • How to Diminish Uneven Skin Tone and Get Your Glow Back
  • What Are Peptides and What Do They Do for Skin?
  • The Truth About Firming Creams
  • Top 5 Reasons to Add Antioxidants to Your Skin Care Routine
  • Anti-Aging Superstars
Estimated level
1–3%
Confidence
Moderate — INCI order above the 1% line

17th on the list, which puts it at an estimated 1–3% of the formula.

Cyclohexanol, 4-(1,1-dimethylethyl)-

5 scientific references
  • Journal of Cosmetic Dermatology, June 2020, pages 1,409-1,414
  • International Journal of Cosmetic Science, December 2019, pages 534–547
  • Clinical, Cosmetic and Investigational Dermatology, September 2018, pages 421-429
  • Journal of the European Academy of Dermatology and Venereology, February 2016, pages 9-16; and Volume 30 Supplement, pages 21-27
  • Experimental Dermatology, November 2010, pages 980-986
Estimated level
1–3%
Confidence
Moderate — INCI order above the 1% line
Roles
Plant extract, Texture agent

18th on the list, which puts it at an estimated 1–3% of the formula.

Chondrus Crispus Extract is an extract of the carrageenan, Chondrus crispus, Gigartinaceae

Estimated level
1–3%
Confidence
Moderate — INCI order above the 1% line
Roles
Texture agent

19th on the list, which puts it at an estimated 1–3% of the formula.

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer is a copolymer of sodium hydroxyethyl acrylate and acryloyldimethyl taurate monomers

Synthetic polymer
20 Glyceryl Stearate Emollient
Estimated level
1–3%
Confidence
Moderate — INCI order above the 1% line
Roles
Emollient, Surfactant

20th on the list, which puts it at an estimated 1–3% of the formula.

Stearic acid, monoester with glycerol

Hydration
3 scientific references
  • Cosmeticsinfoorg, Accessed November 2021, ePublication
  • Drugs in Context, April 2018, pages 1-14
  • International Journal of Toxicology, May 2007, pages 1–30
21 Peg-100 Stearate Surfactant
Estimated level
1–3%
Confidence
Moderate — INCI order above the 1% line
Roles
Surfactant

21st on the list, which puts it at an estimated 1–3% of the formula.

Poly(oxy-1,2-ethanediyl), .alpha.-(1-oxooctadecyl)-.omega.-hydroxy- (100 mol EO average molar ratio)

Estimated level
1–3%
Confidence
Moderate — INCI order above the 1% line
Roles
Emollient

22nd on the list, which puts it at an estimated 1–3% of the formula.

Olive oil, unsaponifiable fraction, hydrogenated

Estimated level
1–3%
Confidence
Moderate — INCI order above the 1% line
Roles
Humectant, Plant extract

23rd on the list, which puts it at an estimated 1–3% of the formula.

Saccharum Officinarum Extract is an extract of the sugar cane, Saccharum officinarum L., Poaceae

Estimated level
1–3%
Confidence
Moderate — INCI order above the 1% line
Roles
Surfactant

24th on the list, which puts it at an estimated 1–3% of the formula.

C12-20 Alkyl Glucoside is the product obtained by the condensation of C12-20 alcohols with glucose

25 1,2-hexanediol Solvent
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Solvent

25th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

26 Carbomer Texture agent
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Texture agent

26th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

2-Propenoic acid, polymer with 2,2-bis(hydroxymethyl)propane-1,3-diol 2-propenyl ether

Synthetic polymer
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Active

27th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Anti-Acne Anti-Aging Evens Skin Tone
28 Tromethamine pH adjuster
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
pH adjuster

28th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

1,3-Propanediol, 2-amino-2-(hydroxymethyl)-

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

29th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

1,2-Propanediol, 3-(2-ethylhexyloxy)

Hydration
5 scientific references
  • PLoS One, October 2016, ePublication
  • Contact Dermatitis, May 2016, pages 281-288
  • International Journal of Toxicology, September 2013, pages 5S-21S
  • Personal Care, 2008, pages 1-4
  • Cosmetic Science Technology, 2006, pages 1-11
30 Xanthan Gum Surfactant
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Surfactant, Texture agent

30th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Xanthan gum

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

31st on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

6-Amino-9-beta-D-ribofuranosyl-9H-purine

Soothing
8 scientific references
  • PubChem, Accessed May 2021, ePublication
  • Cosmetic Ingredient Review, September 2020, pages 1-38
  • Experimental Dermatology, August 2014, pages 553-554
  • Journal of Investigative Dermatology, August 2011, pages 526-546
  • International Journal of Cosmetic Science, December 2006, pages 447-451
  • British Journal of Pharmacology, October 2008, issue 4, pages 475-486
  • PloS One, May 2008 (ePublication)
  • >International Journal of Cosmetic Science, August 2006, pages 447-451
32 Palmitic Acid Emollient
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Emollient, Surfactant

32nd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Hexadecanoic acid

33 Stearic Acid Emollient
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Emollient, Surfactant, Texture agent

33rd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Stearic acid

Hydration
4 scientific references
  • Cosmetic Ingredient Review, May 2019, pages 1-61
  • International Journal of Cosmetic Science, August 2008, page 310
  • Therapeutics for the Clinician, May 2005, pages 317-324
  • Journal of Cosmetic Science, December 2003, pages 559-568
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Surfactant

34th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Sorbitan, isooctadecanoate

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Humectant, Active

35th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Hyaluronic acid, sodium, salt

Hydration Anti-Aging Soothing
5 scientific references
  • Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und Verwandte Gebiete, December 2017, pages 987-993
  • Journal of Cosmetic Dermatology, July 2014, pages 277-287
  • Journal of Clinical and Aesthetic Dermatology, October 2012, pages 20-23
  • DermatoEndocrinology, July-December 2012, pages 253-258
  • Journal of Drugs in Dermatology, September 2011, pages 990-1000
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Occlusive, Plant extract

36th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Paeonia Suffruticosa Root Extract is an extract of the roots of the Chinese Peony, Paeonia suffruticosa, Ranunculaceae

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

37th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

beta-Glucan is a polysaccharide consisting of b(1-3) linked glucose chains carrying b(1-6) linked glucose sidechains

Soothing Hydration
6 scientific references
  • Journal of Cosmetic Dermatology, December 2018, pages 1, 101-1, 107
  • International Journal of Molecular Sciences, September 2017, pages 1-48
  • Phytotherapy Research, February 2014, pages 159-166
  • Cosmetic Ingredient Review, October 2012, pages 1-52
  • Journal of Drugs in Dermatology, February 2007, pages 167-170
  • International Journal of Cosmetic Science, October 2005, page 292
38 Tocopherol Antioxidant
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Antioxidant

38th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ol; .alpha.-tocopherol; Vitamin E

Anti-Aging Evens Skin Tone Soothing
4 scientific references
  • Journal or Agricultural and Food Chemistry, June 2010, pages 7013-7020
  • Journal of Investigative Dermatology, November 2001, pages 1212-1217
  • Canadian Family Physician, July 2006, pages 855-856
  • Dermatologic Surgery, April 1999, pages 311-315

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Frequently asked questions

What ingredients are in Advanced Retino-Mela Serum?

WATER, BUTYLENE GLYCOL, NIACINAMIDE, SQUALANE, TRANEXAMIC ACID, METHYL TRIMETHICONE, PENTYLENE GLYCOL, GLYCERIN, HYDROGENATED ETHYLHEXYL OLIVATE, BETAINE, PROPANEDIOL, DIMETHYL ISOSORBIDE, C14-22 ALCOHOLS, BISABOLOL, PANTHENOL, TOCOPHERYL ACETATE, 4-T-BUTYLCYCLOHEXANOL, CHONDRUS CRISPUS EXTRACT, HYDROXYETHYL ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER, GLYCERYL STEARATE, PEG-100 STEARATE, HYDROGENATED OLIVE OIL UNSAPONIFIABLES, SACCHARUM OFFICINARUM EXTRACT, C12-20 ALKYL GLUCOSIDE, 1,2-HEXANEDIOL, CARBOMER, HYDROXYPINACOLONE RETINOATE, TROMETHAMINE, ETHYLHEXYLGLYCERIN, XANTHAN GUM, ADENOSINE, PALMITIC ACID, STEARIC ACID, SORBITAN ISOSTEARATE, SODIUM HYALURONATE, PAEONIA SUFFRUTICOSA ROOT EXTRACT, BETA-GLUCAN, TOCOPHEROL.

What are the active ingredients in Advanced Retino-Mela Serum?

NIACINAMIDE, PANTHENOL, HYDROXYPINACOLONE RETINOATE, SODIUM HYALURONATE.

How do I use Advanced Retino-Mela Serum?

Apply a small amount to clean, dry skin in the evening after toner. Start 2–3 times per week and gradually increase frequency as tolerated. Follow with moisturizer. Always use sunscreen during the day.

What skin types is Advanced Retino-Mela Serum good for?

Judged on how rich the formula reads from its ingredient list, it suits Balanced, Combination (oily), Oily skin best. It is the least natural fit for Dry, Combination (dry) skin.

Is Advanced Retino-Mela Serum good for sensitive skin?

No ingredient in this formula carries a common-irritant flag, making it a reasonable option for reactive skin. A patch test is still recommended, as individual skin reactivity varies.

Is Advanced Retino-Mela Serum fungal acne safe?

4 ingredients could feed malassezia: Hydrogenated Ethylhexyl Olivate, Glyceryl Stearate, Peg-100 Stearate, Sorbitan Isostearate. That describes the yeast's food supply, not a prediction that they will cause a breakout.

Can I use Advanced Retino-Mela Serum while pregnant?

It contains Hydroxypinacolone Retinoate, which are usually reviewed with a doctor during pregnancy. Ask your doctor or midwife before using it.

Is Advanced Retino-Mela Serum fragrance free?

Yes. Reading the full ingredient list, this formula is fragrance-free.

Does Advanced Retino-Mela Serum contain alcohol?

No. Reading the full ingredient list, this formula is no drying alcohol.

Is Advanced Retino-Mela Serum silicone free?

No — it contains Methyl Trimethicone.

Does Advanced Retino-Mela Serum contain essential oils?

No. Reading the full ingredient list, this formula is essential-oil-free.

Is Advanced Retino-Mela Serum paraben free?

Yes. Reading the full ingredient list, this formula is paraben-free.

What can I layer with Advanced Retino-Mela Serum?

It layers well with Retinoids (retinol, retinal), Copper peptides, Bakuchiol, Niacinamide, Hyaluronic acid, Ceramides. Take more care combining it with AHAs (glycolic, lactic), BHA (salicylic acid), PHAs (gluconolactone), Benzoyl peroxide, Vitamin C (L-ascorbic acid), Azelaic acid — use them in separate routines or on alternate days.

When should I apply Advanced Retino-Mela Serum?

Use it morning and evening, after toner, before moisturiser.

How many ingredients does Advanced Retino-Mela Serum have?

It lists 38 ingredients, of which 4 are recorded as actives.

Who makes Advanced Retino-Mela Serum?

Dr. Reju-All, a brand based in Korea.

Brand
Dr. Reju-All
Country
Korea

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