Mary&May Spicule Collagen PDRN Cream

Mary&May

Spicule Collagen PDRN Cream

face neck cream

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Fit by skin type

General, ingredient-based — not your personalized match.

Dry
61%
Combination (dry)
61%
Balanced
91%
Combination (oily)
79%
Oily
79%

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48
Ingredients
6
Benefits
4
Actives
Find Dupes

The Mary&May Spicule Collagen PDRN Cream is a firming and skin-repair moisturizer designed to improve elasticity, enhance hydration, and support overall skin regeneration. This advanced cream helps deliver active ingredients deeper into the skin while promoting a smoother, more resilient complexion. Its rich yet comfortable texture nourishes the skin while helping to improve firmness and reduce the appearance of fine lines. With continued use, the Mary&May Spicule Collagen PDRN Cream leaves the skin looking plumper, more lifted, and visibly revitalized.

Key Insights

Benefits

6
Anti-Aging
Evens Skin Tone
Hydration
Oil Control
Pore Minimizer
Soothing

Active Ingredients

4
Ceramides Hyaluronic acid Vitamin B3 (niacinamide) Vitamin B5 (panthenol)

Risks

2
Silicone
Synthetic polymer

About Spicule Collagen PDRN Cream

Overview

Spicule Collagen PDRN Cream is a lightweight cream from Mary&May, a brand based in Korea. The formula is built mainly around hydration. The ingredient list runs to 48 ingredients, each broken down in full below.

Texture and finish

By its ingredient list the formula reads as light: water and humectants lead, with emollients kept lower in the order. It contains both silicones and oils, a combination that usually finishes smooth and slightly satin and sits well under makeup. Hydration is handled by Methylpropanediol, Glycerin and Panthenol, humectants that pull water into the upper layers of skin rather than sealing it there.

What the formula does

Hydration: Very high. Ingredients that pull and hold water in the upper layers of skin, and here that comes from Methylpropanediol, Glycerin, Panthenol and Ethylhexylglycerin.

Soothing: Moderate. Ingredients aimed at visible redness and reactivity, and here that comes from Panthenol, Cetyl Ethylhexanoate, Allantoin and Niacinamide.

Barrier support: Moderate. Lipids and repair signals that support skin barrier integrity, and here that comes from Niacinamide, Panthenol, Cholesterol and Butyrospermum Parkii Butter.

Who it suits

On richness alone it suits Balanced skin best, and is the least natural fit for Dry and Combination (dry) skin. Nothing in the list is flagged as a common irritant, which is a reasonable starting point for reactive skin — though a patch test is still the only way to know.

What it does not target

The formula contributes little or nothing on antioxidant protection, cell renewal and firmness signalling. That is not a fault — most products are not meant to do everything — but if one of those is your priority, this is not the product that will address it.

What is not in it

Reading the full list, the formula is fragrance-free, essential-oil-free, no drying alcohol, paraben-free, microplastic-free and sulfate-free. Those claims come from the ingredient list itself, not from the packaging.

Where it fits in a routine

It can be used morning and evening. In a routine it goes after serums. Seal in your serums with it; in the morning, sunscreen still goes on top.

This summary is generated from the product's ingredient list. It is not a review, it is not the brand's own marketing claims, and it does not replace advice from a dermatologist.

Pros and cons

Drawn purely from the ingredient list

Pros

  • No fragrance or declared allergens
  • No essential oils
  • No drying alcohol
  • No microplastics
  • Strong humectant content for hydration
  • No common irritants flagged in the list

Things to know

  • 5 ingredients could feed malassezia (fungal acne)

Which skin types it suits

Scored on how rich or light the formula reads from its INCI order.

Suitable for

  • Balanced skin

May suit

  • Combination (oily) skin
  • Oily skin

Less suitable for

  • Dry skin
  • Combination (dry) skin

Sensitive skin

No ingredient in this formula carries a common-irritant flag, making it a reasonable option for reactive skin. A patch test is still recommended, as individual skin reactivity varies.

Skin concerns

Based on the curated benefits documented for this product's ingredients.

Helps with

  • Hydration 18 ingredients

    Attracts and locks in moisture to keep skin plump and dewy

  • Anti-Aging 9 ingredients

    Boosts collagen and cell turnover to reduce fine lines and wrinkles

  • Soothing 7 ingredients

    Calms redness, irritation, and inflammation for sensitive skin

  • Evens Skin Tone 1 ingredient

    Brightens and balances complexion for a more uniform appearance

  • Oil Control 1 ingredient

    Regulates sebum production to reduce shine and greasiness

  • Pore Minimizer 1 ingredient

    Tightens and refines the look of enlarged pores

Does not target

Anti-Acne Blackhead Reducing Dark Spot Fading Smooths Bumpy Skin

None of the ingredients in this formula are associated with these benefits. This is not unusual, as most products are designed to target a limited number of concerns.

Key ingredients

The actives, UV filters and benefit-carrying ingredients in this formula, in the order they are listed.

1st on the list, which puts it at an estimated 30–80% of the formula.

Aqua (EU),Deionized Water,Distilled Water,Micromatrix Fractile AN,Onsen-Sui (JPN),Purified Water

Hydration

2nd on the list, which puts it at an estimated 5–20% of the formula.

2-Methyl-1,3-propanediol

Hydration

3rd on the list, which puts it at an estimated 5–20% of the formula.

Glycerine ;Glycerol (INN); Glycerol (RIFM); Glycerolum (EP); Glycyl Alcohol; 1,2,3-Propanetriol; 1,2,3-Trihydroxypropane

Hydration Anti-Aging

5th on the list, which puts it at an estimated 2–10% of the formula.

Decanoic acid, ester with 1,2,3-propanetriol octanoate; Glycerides, mixed decanoyl and octanoyl

Hydration
Niacinamide Vitamin B3 (niacinamide)

6th on the list, which puts it at an estimated 2–10% of the formula.

Niacinamide (vitamin B3) is a gentle skincare active that repairs the skin barrier, calms redness, controls oil and evens tone at 2–5%. Official IUPAC name: **3-Pyridinecarboxamide**

Soothing Anti-Aging Pore Minimizer
Panthenol Vitamin B5 (panthenol)

7th on the list, which puts it at an estimated 1–5% of the formula.

Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (2R)-; dl-Panthenol

Hydration Soothing

9th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Ammonium Acryloyldimethyltaurate/VP Copolymer is a copolymer of ammonium acryloyldimethyltaurate and vinylpyrrolidone monomers

Hydration

11th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Stearic acid, monoester with glycerol

Hydration

13th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

L-Arginine

Hydration Anti-Aging

14th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Collagens, hydrolyzates. Substance obtained by acidic, alkaline, or enzymatic hydrolysis of hoofs and horns composed primarily of amino acids, peptides, and proteins. It may contain impurities consisting chiefly of carbohydrates and lipids along with smaller quantities of miscellaneous organic substances of biological origin.

Hydration

15th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Hexadecyl 2-ethylhexanoate

Hydration

19th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ol; .alpha.-tocopherol; Vitamin E

Anti-Aging Evens Skin Tone Soothing

Formula analysis

Each axis is scored from the ingredients present and how high up the list they sit.

Hydration Very high

Ingredients that pull and hold water in the upper layers of skin

Barrier support Moderate

Lipids and repair signals that support skin barrier integrity

Antioxidant support None

Ingredients that mop up free radicals from UV and pollution

Oil control Low

Ingredients that moderate sebum or absorb shine

Brightening Low

Ingredients that act on uneven tone and post-inflammatory marks

Soothing Moderate

Ingredients aimed at visible redness and reactivity

Cell renewal None

Retinoids, acids and enzymes that speed surface turnover

Firmness signalling None

Peptides and growth factors that signal for collagen support

Active and supporting ingredients

"Active" here means an ingredient carrying a recorded active type or a recognised UV filter.

Active ingredients (4)

Supporting ingredients (44)

Solvents, emollients, texture agents and preservatives — the formula that carries the actives.

Water Methylpropanediol Glycerin 1,2-hexanediol Caprylic/capric Triglyceride Polypropylsilsesquioxane Ammonium Acryloyldimethyltaurate/vp Copolymer C14-22 Alcohols Glyceryl Stearate Acrylates/c10-30 Alkyl Acrylate Crosspolymer Arginine Hydrolyzed Collagen Cetyl Ethylhexanoate Macadamia Ternifolia Seed Oil Vinyl Dimethicone C12-20 Alkyl Glucoside Tocopherol Allantoin Brassica Campestris Sterols Polyglyceryl-10 Laurate Ethylhexylglycerin Dextrin Sodium Acrylate/sodium Acryloyldimethyl Taurate Copolymer Cholesterol Hydrolyzed Sponge Phytosteryl/behenyl/octyldodecyl/isostearyl Lauroyl Glutamate Xanthan Gum Polyisobutene Gardenia Florida Fruit Extract Butyrospermum Parkii Butter Adenosine Lauryl Glucoside Polyglyceryl-6 Laurate Hydrogenated Lecithin Disodium Edta Glyceryl Acrylate/acrylic Acid Copolymer Myristyl Glucoside Polyglutamic Acid Caprylyl/capryl Glucoside Pvm/ma Copolymer Stearic Acid Oleic Acid Sodium Guaiazulene Sulfonate Sodium DNA

What is and is not in it

Read from the full ingredient list. A brand's own claim may differ.

Free from

  • Fragrance-free
  • Essential-oil-free
  • No drying alcohol
  • Paraben-free
  • Microplastic-free
  • Sulfate-free
  • Dye-free
  • No animal-derived ingredients

Contains

  • Silicones

    Polypropylsilsesquioxane, Vinyl Dimethicone

  • Facial oils

    Macadamia Ternifolia Seed Oil

What to layer it with

Judged by the same curated rules our routine checker uses. It reads the ingredients, not the label.

Compatible with

  • Vitamin C (L-ascorbic acid)
  • Retinoids (retinol, retinal)
  • AHAs (glycolic, lactic)
  • BHA (salicylic acid)
  • PHAs (gluconolactone)
  • Benzoyl peroxide
  • Azelaic acid
  • Copper peptides
  • Bakuchiol
  • Niacinamide
  • Hyaluronic acid
  • Ceramides
  • Signal peptides
  • Panthenol
  • Sunscreen

Nothing in this formula belongs to a group our rules can put in conflict, so it layers freely. Order still matters — thinnest texture first.

Where it fits in a routine

Morning Evening
  1. Cleanse
  2. Toning
  3. Treat
  4. Moisturise
  5. Protect

This product is the "Moisturise" step.

  • Seal in your serums with it; in the morning, sunscreen still goes on top.

Safety and suitability

Flags to check, not verdicts. None of this is medical advice — if you are pregnant, breastfeeding or treating a skin condition, ask a doctor.

Pregnancy and breastfeeding
Nothing in this formula is on the standard pregnancy-caution list. That is not clearance — ask your doctor about anything you use daily.
Fungal acne (malassezia)
5 ingredients could feed malassezia: Glyceryl Stearate, Macadamia Ternifolia Seed Oil, Polyglyceryl-10 Laurate, Butyrospermum Parkii Butter, Polyglyceryl-6 Laurate. That is about the yeast's food supply, not a prediction that you will break out.
Sensitive and reactive skin
No ingredient in this formula carries a common-irritant flag, making it a reasonable option for reactive skin. A patch test is still recommended, as individual skin reactivity varies.
Recorded ingredient risks
Silicone, Synthetic polymer

Ingredients by function

Most ingredients do more than one job, so these counts add up to more than the 48 ingredients on the label.

15
Texture agent

Sets the thickness, spread and stability of the formula

12
Surfactant

Lifts oil and dirt, or holds oil and water together

9
Emollient

Softens and smooths by filling gaps between skin cells

8
Occlusive

Forms a film that slows water loss

4
Active

Changes how skin behaves rather than how it feels

4
Humectant

Draws water into the upper layers of skin

4
Solvent

Dissolves and carries everything else

1
Antioxidant

Neutralises free radicals from UV and pollution

1
Soothing

Calms visible redness and irritation

1
Chelator

Binds trace metals that would otherwise spoil the formula

1
Plant extract

Botanical material, usually for antioxidants or scent

Ingredient breakdown

Every ingredient on the label, in order, with what it does and roughly how much of it is likely to be there.

1 Water Solvent
Estimated level
30–80%
Confidence
Moderate — INCI order above the 1% line
Roles
Solvent

1st on the list, which puts it at an estimated 30–80% of the formula.

Aqua (EU),Deionized Water,Distilled Water,Micromatrix Fractile AN,Onsen-Sui (JPN),Purified Water

Hydration
3 scientific references
  • Skin Research and Technology, May 2015, pages 131-136
  • Skin Pharmacology and Applied Skin Physiology, November-December 1999, pages 344-351
  • Journal of Cosmetic Science, September-October 1993, pages 249-262
Estimated level
5–20%
Confidence
Moderate — INCI order above the 1% line
Roles
Solvent

2nd on the list, which puts it at an estimated 5–20% of the formula.

2-Methyl-1,3-propanediol

Hydration
3 scientific references
  • PubChem, Accessed April 2021, ePublication
  • Cosmetic Ingredient Review, June 2018, pages 1-73
  • Contact Dermatitis, September 2017, pages 159-162
3 Glycerin Humectant
Estimated level
5–20%
Confidence
Moderate — INCI order above the 1% line
Roles
Humectant, Occlusive, Texture agent, Solvent

3rd on the list, which puts it at an estimated 5–20% of the formula.

Glycerine ;Glycerol (INN); Glycerol (RIFM); Glycerolum (EP); Glycyl Alcohol; 1,2,3-Propanetriol; 1,2,3-Trihydroxypropane

Hydration Anti-Aging
6 scientific references
  • Journal of Pharmaceutical Investigation, March 2021, pages 223-231
  • International Journal of Toxicology, November/December 2019, Volume 38, Supplement 3, pages 6S-22S
  • International Journal of Cosmetic Science, August 2016, ePublication
  • British Journal of Dermatology, July 2008, pages 23-34
  • Journal of Cosmetic Dermatology, June 2007, pages 75-82
  • Proceedings of the National Academy of Sciences, June 2003, pages 7, 360-7, 365
Estimated level
2–10%
Confidence
Moderate — INCI order above the 1% line
Roles
Solvent

4th on the list, which puts it at an estimated 2–10% of the formula.

Estimated level
2–10%
Confidence
Moderate — INCI order above the 1% line

5th on the list, which puts it at an estimated 2–10% of the formula.

Decanoic acid, ester with 1,2,3-propanetriol octanoate; Glycerides, mixed decanoyl and octanoyl

Hydration
5 scientific references
  • International Journal of Toxicology, September 2020, pages 34-35
  • Periodica Polytechnica Chemical Engineering, 2014, pages 43-48
  • International Journal of Toxicology, January 2003, pages 4-5
  • Food and Chemical Toxicology, January 2000, pages 79-98
  • Journal of the Society of Cosmetic Chemists, August 1985, pages 303-311
6 Niacinamide Active
Estimated level
2–10%
Confidence
Moderate — INCI order above the 1% line
Roles
Active

6th on the list, which puts it at an estimated 2–10% of the formula.

Niacinamide (vitamin B3) is a gentle skincare active that repairs the skin barrier, calms redness, controls oil and evens tone at 2–5%. Official IUPAC name: **3-Pyridinecarboxamide**

Soothing Anti-Aging Pore Minimizer
15 scientific references
  • International Journal of Dermatology, February 2021, pages 166-173
  • Biomolecules & Therapeutics, July 2019, pages 562-569
  • Experimental Dermatology, February 2019, pages 15-22
  • Dermatologic Therapy, September 2017, ePublication
  • Journal of Investigative Dermatology, May 2017, page S116
  • International Journal of Pharmaceutics, March 2017, pages 158-162
  • Facial Plastic Surgery Clinics of North America, May 2016, pages 145-152
  • Clinical, Cosmetic, and Investigational Dermatology, July 2015, pages 405-412
  • Skin Pharmacology and Physiology, June 2014, pages 311-315
  • International Journal of Pharmacy, January 2013, pages 192-201
  • Dermatoendrocrinology, July 2012, pages 308-319
  • International Journal of Toxicology, September 2005, pages 1-31
  • Dermatologic Surgery, July 2005, pages 860-865
  • International Journal of Cosmetic Science, October 2004, pages 231-238
  • Journal of Cosmetic Dermatology, April 2004, pages 88-93
7 Panthenol Active
Estimated level
1–5%
Confidence
Moderate — INCI order above the 1% line
Roles
Active

7th on the list, which puts it at an estimated 1–5% of the formula.

Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (2R)-; dl-Panthenol

Hydration Soothing
7 scientific references
  • The Linus Pauling Institute, Oregon State University, Accessed April 2021, ePublication
  • International Journal of Cosmetic Science, December 2019, pages 534-547
  • Journal of Cosmetic Dermatology, January 2019, pages 346-354
  • Cosmetic Ingredient Review, March 2018, pages 1-51
  • The Journal of Dermatological Treatment, August 2017, pages 173-180
  • Journal of Cosmetic Science, August 2011, pages 361-370
  • American Journal of Clinical Dermatology, Volume 3, 2002, pages 427-433
Estimated level
1–5%
Confidence
Moderate — INCI order above the 1% line
Roles
Occlusive

8th on the list, which puts it at an estimated 1–5% of the formula.

Polymer formed by hydrolysis and condensation of propyltrichlorosilane

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Texture agent

9th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Ammonium Acryloyldimethyltaurate/VP Copolymer is a copolymer of ammonium acryloyldimethyltaurate and vinylpyrrolidone monomers

Hydration
10 C14-22 Alcohols Texture agent
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Texture agent

10th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

C14-22 Alcohols is a mixture of synthetic fatty alcohols with 14 to 22 carbons in the alkyl chain

11 Glyceryl Stearate Emollient
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Emollient, Surfactant

11th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Stearic acid, monoester with glycerol

Hydration
3 scientific references
  • Cosmeticsinfoorg, Accessed November 2021, ePublication
  • Drugs in Context, April 2018, pages 1-14
  • International Journal of Toxicology, May 2007, pages 1–30
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Occlusive, Texture agent

12th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

C10-30 alkyl propenoate, polymer with propenoic acid, butenoic acidand/or alkyl propenoates, product with propenyl sucrose ether or propenyl 2,2-dihydroxymethyl-1,3-propanediol

Synthetic polymer
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

13th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

L-Arginine

Hydration Anti-Aging
6 scientific references
  • Biobased Surfactants (Second Edition), 2019, pages 413-445
  • Scientific Reports, February 2016, pages 1-10
  • Cosmetic Ingredient Review, October 2012, pages 1-35
  • Journal of Advanced Research, July 2010, pages 169–177
  • International Journal of Cosmetic Science, April 2005, page 139
  • Wound Repair and Regeneration, November-December 2003, pages 419-423
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Humectant, Emollient, Occlusive

14th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Collagens, hydrolyzates. Substance obtained by acidic, alkaline, or enzymatic hydrolysis of hoofs and horns composed primarily of amino acids, peptides, and proteins. It may contain impurities consisting chiefly of carbohydrates and lipids along with smaller quantities of miscellaneous organic substances of biological origin.

Hydration
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Emollient

15th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Hexadecyl 2-ethylhexanoate

Hydration
2 scientific references
  • Engineering in Life Sciences, March 2019, pages 370-388
  • International Journal of Toxicology, Nov-Dec 2015, pages 61S-73S
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Emollient

16th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Macadamia Ternifolia Seed Oil is the fixed oil obtained from the nuts of the Bushnut, Macadamia ternifolia, Proteaceae. It consists primarily of the glycerides of the fatty acids

17 Vinyl Dimethicone Texture agent
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Texture agent

17th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Silicones and siloxanes, dimethyl, ethenyl methyl, ethenyldimethylsilyl terminated

Silicone
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Surfactant

18th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

C12-20 Alkyl Glucoside is the product obtained by the condensation of C12-20 alcohols with glucose

19 Tocopherol Antioxidant
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Antioxidant

19th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ol; .alpha.-tocopherol; Vitamin E

Anti-Aging Evens Skin Tone Soothing
4 scientific references
  • Journal or Agricultural and Food Chemistry, June 2010, pages 7013-7020
  • Journal of Investigative Dermatology, November 2001, pages 1212-1217
  • Canadian Family Physician, July 2006, pages 855-856
  • Dermatologic Surgery, April 1999, pages 311-315
20 Allantoin Occlusive
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Occlusive, Soothing

20th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Urea, (2,5-dioxo-4-imidazolidinyl)-

Soothing
8 scientific references
  • Chemistry Series, March 2020, pages 7-21
  • Molecules, June 2019, pages 1-33
  • European Journal of Pharmacology, February 2018, pages 68-78
  • Journal of the American Academy of Dermatology, June 2017, Volume 76, Issue 2, Supplement 1
  • Pharmacognosy Review, Volume 5, July-December 2011
  • International Journal of Toxicology, May 2010, Supplement, pages 84S-97S
  • Journal of Occupational Medicine and Toxicology, October 2008, ePublication
  • https://wwwaccessdatafdagov/scripts/cdrh/cfdocs/cfcfr/CFRSearchcfm?CFRPart=347&showFR=1
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Emollient

21st on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Brassica Campestris Sterols is a mixture of sterols obtained from the Cabbage, Brassica campestris L., Brassicaceae

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

22nd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

1,2,3-Propanetriol, homopolymer, dodecanoates (1:1) (10 mol glycerol average molar ratio)

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

23rd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

1,2-Propanediol, 3-(2-ethylhexyloxy)

Hydration
5 scientific references
  • PLoS One, October 2016, ePublication
  • Contact Dermatitis, May 2016, pages 281-288
  • International Journal of Toxicology, September 2013, pages 5S-21S
  • Personal Care, 2008, pages 1-4
  • Cosmetic Science Technology, 2006, pages 1-11
24 Dextrin Texture agent
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Texture agent

24th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Dextrin

Oil Control
8 scientific references
  • Oil-Absorbing Ingredients
  • Help for Oily Skin
  • Salicylic Acid for Skin
  • How BHA Exfoliants Work
  • Which BHA Exfoliant is Right for Me?
  • Niacinamide Benefits: What Does Niacinamide Do for Skin?
  • The Best Toners for Oily Skin
  • The Best Moisturizers for Oily, Acne-Prone Skin
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Occlusive, Texture agent

25th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer is a copolymer of sodium acrylate and sodium acryloyldimethyl taurate monomers

Synthetic polymer
26 Cholesterol Emollient
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Emollient, Surfactant, Texture agent

26th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Cholest-5-en-3-ol (beta)-

Hydration Anti-Aging
4 scientific references
  • Frontiers in Bioengineering and Biotechnology, August 2015, pages 1-6
  • Journal of Cosmetic Dermatology, July 2007, pages 239-242
  • Journal of Structural Biology, June 2007, pages 386-400
  • International Journal of Toxicology, 2006, pages 1-89
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

27th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Hydrolyzed Sponge is the hydrolysate of sponge obtained by acid, enzyme or other method of hydrolysis

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Emollient

28th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Phytosteryl/Behenyl/Octyldodecyl/Isostearyl Lauroyl Glutamate is the mixed ester of Phytosterol, Behenyl Alcohol, Octyldodecanol and Isostearyl Alcohol with Lauroyl Glutamic Acid

29 Xanthan Gum Surfactant
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Surfactant, Texture agent

29th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Xanthan gum

30 Polyisobutene Occlusive
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Occlusive, Texture agent

30th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Homopolymer of 2-methyl-1 propene

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Plant extract

31st on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Gardenia Florida Fruit Extract is an extract of the fruit of the Cape Jasmine, Gardenia Florida L., Rubiaceae

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Texture agent

32nd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Butyrospermum Parkii Butter is the fat obtained from the fruit of the Shea Tree, Butyrospernum parkii, Sapotaceae

Anti-Aging Hydration Soothing
3 scientific references
  • Journal of Clinical and Aesthetic Dermatology, June 2011, pages 45-55
  • Journal of Agricultural and Food Chemistry, October 2003, pages 6, 268-6, 273
  • Journal of Allergy and Clinical Immunology, February 2009, page S41
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

33rd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

6-Amino-9-beta-D-ribofuranosyl-9H-purine

Soothing
8 scientific references
  • PubChem, Accessed May 2021, ePublication
  • Cosmetic Ingredient Review, September 2020, pages 1-38
  • Experimental Dermatology, August 2014, pages 553-554
  • Journal of Investigative Dermatology, August 2011, pages 526-546
  • International Journal of Cosmetic Science, December 2006, pages 447-451
  • British Journal of Pharmacology, October 2008, issue 4, pages 475-486
  • PloS One, May 2008 (ePublication)
  • >International Journal of Cosmetic Science, August 2006, pages 447-451
34 Lauryl Glucoside Surfactant
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Surfactant

34th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

D-Glucose homopolymer, dodecyl ether

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Surfactant

35th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

1,2,3-Propanetriol, homopolymer, dodecanoates (1:1) (6 mol glycerol average molar ratio)

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Surfactant

36th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Lecithins, hydrogenated

Hydration
4 scientific references
  • International Journal of Toxicology, September 2020, pages 5S-25S
  • Nanocosmetics, June 2019, pages 95–140
  • Current Drug Delivery, 2016, pages 111–120
  • Pharmaceutical Research, February 2013, pages 538–55
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Humectant, Active

37th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Hyaluronic acid, sodium, salt

Hydration Anti-Aging Soothing
5 scientific references
  • Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und Verwandte Gebiete, December 2017, pages 987-993
  • Journal of Cosmetic Dermatology, July 2014, pages 277-287
  • Journal of Clinical and Aesthetic Dermatology, October 2012, pages 20-23
  • DermatoEndocrinology, July-December 2012, pages 253-258
  • Journal of Drugs in Dermatology, September 2011, pages 990-1000
38 Disodium Edta Texture agent
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Texture agent, Chelator

38th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Disodium dihydrogen ethylenediaminetetraacetate

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Humectant, Texture agent

39th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Glyceryl Acrylate/Acrylic Acid Copolymer is a copolymer of glyceryl acrylate and acrylic acid

Synthetic polymer
40 Myristyl Glucoside Surfactant
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Surfactant

40th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Tetradecyl D-glucopyranoside

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

41st on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Polymer of glutamic acid

Hydration Anti-Aging
5 scientific references
  • Biomass Conversion and Biorefinery, March 2021, ePublication
  • Molecules, July 2020, pages 1–33
  • Journal of Materials Science, Materials in Medicine, Volume 31, May 2020, ePublication
  • Journal of Biomedical Materials Research, November 2017, pages
  • Saudi Journal of Biological Sciences, April 2014, pages 153–158
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Surfactant

42nd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

D-Glucopyranose, oligomers, decyl octyl glycosides

43 Pvm/ma Copolymer Occlusive
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Occlusive, Texture agent

43rd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

2,5-Furandione, polymer with methoxyethene; copolymer of methyl vinyl ether and maleic anhydride

44 Ceramide NP Active
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Active

44th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Ceramide NP,1,3,4-Octadecanetriol, 2-Octadecanamide,Stearoyl-C18-Phytosphingosine,Stearoyl-4-Hydroxysphinganine

Hydration Anti-Aging
11 scientific references
  • International Journal of Toxicology, 2020, pages 5S-25S
  • International Journal of Molecular Sciences, August 2019, pages 1-15
  • Skin Pharmacology and Physiology, 2016, pages 135-147
  • Biochimica et Biophysica Acta, October 2014, pages 2473-2483
  • Journal of the American Academy of Dermatology, July 2014, pages 177-184
  • Journal of Lipid Research, July 2008, pages 1, 466-1, 476
  • Journal of Lipid Research, September 2007, pages 1936-1943
  • American Journal of Clinical Dermatology, 2003, pages 107-129
  • Contact Dermatitis, June 2002, pages 331-338
  • Journal of Investigative Dermatology, November 2001, pages 1, 126-1, 136
  • Skin Pharmacology and Applied Skin Physiology, September-October 2001, pages 261-271
45 Stearic Acid Emollient
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Emollient, Surfactant, Texture agent

45th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Stearic acid

Hydration
4 scientific references
  • Cosmetic Ingredient Review, May 2019, pages 1-61
  • International Journal of Cosmetic Science, August 2008, page 310
  • Therapeutics for the Clinician, May 2005, pages 317-324
  • Journal of Cosmetic Science, December 2003, pages 559-568
46 Oleic Acid Emollient
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Emollient, Surfactant

46th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

9-Octadecenoic acid (9Z)-

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Surfactant

47th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Sodium 3,8-dimethyl-5-(isopropyl)-1-azulenesulfonate

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

48th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Deoxyribonucleic acid, sodium salts

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Frequently asked questions

What ingredients are in Spicule Collagen PDRN Cream?

WATER, METHYLPROPANEDIOL, GLYCERIN, 1,2-HEXANEDIOL, CAPRYLIC/CAPRIC TRIGLYCERIDE, NIACINAMIDE, PANTHENOL, POLYPROPYLSILSESQUIOXANE, AMMONIUM ACRYLOYLDIMETHYLTAURATE/VP COPOLYMER, C14-22 ALCOHOLS, GLYCERYL STEARATE, ACRYLATES/C10-30 ALKYL ACRYLATE CROSSPOLYMER, ARGININE, HYDROLYZED COLLAGEN, CETYL ETHYLHEXANOATE, MACADAMIA TERNIFOLIA SEED OIL, VINYL DIMETHICONE, C12-20 ALKYL GLUCOSIDE, TOCOPHEROL, ALLANTOIN, BRASSICA CAMPESTRIS STEROLS, POLYGLYCERYL-10 LAURATE, ETHYLHEXYLGLYCERIN, DEXTRIN, SODIUM ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER, CHOLESTEROL, HYDROLYZED SPONGE, PHYTOSTERYL/BEHENYL/OCTYLDODECYL/ISOSTEARYL LAUROYL GLUTAMATE, XANTHAN GUM, POLYISOBUTENE, GARDENIA FLORIDA FRUIT EXTRACT, BUTYROSPERMUM PARKII BUTTER, ADENOSINE, LAURYL GLUCOSIDE, POLYGLYCERYL-6 LAURATE, HYDROGENATED LECITHIN, SODIUM HYALURONATE, DISODIUM EDTA, GLYCERYL ACRYLATE/ACRYLIC ACID COPOLYMER, MYRISTYL GLUCOSIDE, POLYGLUTAMIC ACID, CAPRYLYL/CAPRYL GLUCOSIDE, PVM/MA COPOLYMER, CERAMIDE NP, STEARIC ACID, OLEIC ACID, SODIUM GUAIAZULENE SULFONATE, SODIUM DNA.

What are the active ingredients in Spicule Collagen PDRN Cream?

NIACINAMIDE, PANTHENOL, SODIUM HYALURONATE, CERAMIDE NP.

How do I use Spicule Collagen PDRN Cream?

Apply an appropriate amount as the final step of your skincare routine. Gently massage into the face and neck until fully absorbed. Use morning and evening.

What skin types is Spicule Collagen PDRN Cream good for?

Judged on how rich the formula reads from its ingredient list, it suits Balanced skin best. It is the least natural fit for Dry, Combination (dry) skin.

Is Spicule Collagen PDRN Cream good for sensitive skin?

No ingredient in this formula carries a common-irritant flag, making it a reasonable option for reactive skin. A patch test is still recommended, as individual skin reactivity varies.

Is Spicule Collagen PDRN Cream fungal acne safe?

5 ingredients could feed malassezia: Glyceryl Stearate, Macadamia Ternifolia Seed Oil, Polyglyceryl-10 Laurate, Butyrospermum Parkii Butter, Polyglyceryl-6 Laurate. That describes the yeast's food supply, not a prediction that they will cause a breakout.

Can I use Spicule Collagen PDRN Cream while pregnant?

Nothing in this formula is on the standard pregnancy-caution list. That is not medical clearance — check anything you use daily with your doctor or midwife.

Is Spicule Collagen PDRN Cream fragrance free?

Yes. Reading the full ingredient list, this formula is fragrance-free.

Does Spicule Collagen PDRN Cream contain alcohol?

No. Reading the full ingredient list, this formula is no drying alcohol.

Is Spicule Collagen PDRN Cream silicone free?

No — it contains Polypropylsilsesquioxane, Vinyl Dimethicone.

Does Spicule Collagen PDRN Cream contain essential oils?

No. Reading the full ingredient list, this formula is essential-oil-free.

Is Spicule Collagen PDRN Cream paraben free?

Yes. Reading the full ingredient list, this formula is paraben-free.

What can I layer with Spicule Collagen PDRN Cream?

It layers well with Vitamin C (L-ascorbic acid), Retinoids (retinol, retinal), AHAs (glycolic, lactic), BHA (salicylic acid), PHAs (gluconolactone), Benzoyl peroxide.

When should I apply Spicule Collagen PDRN Cream?

Use it morning and evening, after serums.

How many ingredients does Spicule Collagen PDRN Cream have?

It lists 48 ingredients, of which 4 are recorded as actives.

Who makes Spicule Collagen PDRN Cream?

Mary&May, a brand based in Korea.

Brand
Mary&May
Country
Korea

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