Mary&May Spicule Retinol PDRN Cream

Mary&May

Spicule Retinol PDRN Cream

face cream

Added Last edited

Fit by skin type

General, ingredient-based — not your personalized match.

Dry
63%
Combination (dry)
63%
Balanced
93%
Combination (oily)
77%
Oily
77%

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50
Ingredients
6
Benefits
4
Actives
Find Dupes

The Mary&May Spicule Retinol PDRN Cream is an advanced anti-aging moisturizer designed to improve skin texture, boost elasticity, and support visible skin regeneration. This high-performance formula enhances the delivery of active ingredients while promoting skin renewal. It works to smooth fine lines, refine pores, and improve overall skin firmness.

Key Insights

Benefits

6
Anti-Acne
Anti-Aging
Hydration
Oil Control
Pore Minimizer
Soothing

Active Ingredients

4
Ceramides Retinoids Vitamin B3 (niacinamide) Vitamin B5 (panthenol)

Risks

3
Pregnancy Unsafe
Silicone
Synthetic polymer

About Spicule Retinol PDRN Cream

Overview

Spicule Retinol PDRN Cream is a lightweight cream from Mary&May, a brand based in Korea. The formula is built mainly around hydration. The ingredient list runs to 50 ingredients, each broken down in full below.

Texture and finish

By its ingredient list the formula reads as light: water and humectants lead, with emollients kept lower in the order. It contains both silicones and oils, a combination that usually finishes smooth and slightly satin and sits well under makeup. Hydration is handled by Methylpropanediol, Glycerin and Panthenol, humectants that pull water into the upper layers of skin rather than sealing it there.

What the formula does

Hydration: Very high. Ingredients that pull and hold water in the upper layers of skin, and here that comes from Methylpropanediol, Glycerin, Panthenol and Ethylhexylglycerin.

Barrier support: Moderate. Lipids and repair signals that support skin barrier integrity, and here that comes from Niacinamide, Panthenol, Cholesterol and Butyrospermum Parkii Butter.

Soothing: Moderate. Ingredients aimed at visible redness and reactivity, and here that comes from Panthenol, Cetyl Ethylhexanoate, Allantoin and Niacinamide.

Oil control: Moderate. Ingredients that moderate sebum or absorb shine, and here that comes from Niacinamide, Retinol and Dextrin.

Who it suits

On richness alone it suits Balanced skin best, and is the least natural fit for Dry and Combination (dry) skin. Nothing in the list is flagged as a common irritant, which is a reasonable starting point for reactive skin — though a patch test is still the only way to know.

What it does not target

The formula contributes little or nothing on antioxidant protection, cell renewal and firmness signalling. That is not a fault — most products are not meant to do everything — but if one of those is your priority, this is not the product that will address it.

What is not in it

Reading the full list, the formula is fragrance-free, essential-oil-free, no drying alcohol, paraben-free, microplastic-free and sulfate-free. Those claims come from the ingredient list itself, not from the packaging.

Where it fits in a routine

It can be used morning and evening. In a routine it goes after serums. Seal in your serums with it; in the morning, sunscreen still goes on top.

This summary is generated from the product's ingredient list. It is not a review, it is not the brand's own marketing claims, and it does not replace advice from a dermatologist.

Pros and cons

Drawn purely from the ingredient list

Pros

  • No fragrance or declared allergens
  • No essential oils
  • No drying alcohol
  • No microplastics
  • Strong humectant content for hydration
  • No common irritants flagged in the list

Things to know

  • 8 ingredients could feed malassezia (fungal acne)
  • Contains ingredients usually flagged for review during pregnancy

Which skin types it suits

Scored on how rich or light the formula reads from its INCI order.

Suitable for

  • Balanced skin

May suit

  • Combination (oily) skin
  • Oily skin

Less suitable for

  • Dry skin
  • Combination (dry) skin

Sensitive skin

No ingredient in this formula carries a common-irritant flag, making it a reasonable option for reactive skin. A patch test is still recommended, as individual skin reactivity varies.

Skin concerns

Based on the curated benefits documented for this product's ingredients.

Helps with

  • Hydration 17 ingredients

    Attracts and locks in moisture to keep skin plump and dewy

  • Anti-Aging 9 ingredients

    Boosts collagen and cell turnover to reduce fine lines and wrinkles

  • Soothing 5 ingredients

    Calms redness, irritation, and inflammation for sensitive skin

  • Pore Minimizer 2 ingredients

    Tightens and refines the look of enlarged pores

  • Anti-Acne 1 ingredient

    Targets breakouts by reducing bacteria and unclogging pores

  • Oil Control 1 ingredient

    Regulates sebum production to reduce shine and greasiness

Does not target

Blackhead Reducing Dark Spot Fading Evens Skin Tone Smooths Bumpy Skin

None of the ingredients in this formula are associated with these benefits. This is not unusual, as most products are designed to target a limited number of concerns.

Key ingredients

The actives, UV filters and benefit-carrying ingredients in this formula, in the order they are listed.

1st on the list, which puts it at an estimated 30–80% of the formula.

Aqua (EU),Deionized Water,Distilled Water,Micromatrix Fractile AN,Onsen-Sui (JPN),Purified Water

Hydration

2nd on the list, which puts it at an estimated 5–20% of the formula.

2-Methyl-1,3-propanediol

Hydration

3rd on the list, which puts it at an estimated 5–20% of the formula.

Glycerine ;Glycerol (INN); Glycerol (RIFM); Glycerolum (EP); Glycyl Alcohol; 1,2,3-Propanetriol; 1,2,3-Trihydroxypropane

Hydration Anti-Aging
Niacinamide Vitamin B3 (niacinamide)

5th on the list, which puts it at an estimated 2–10% of the formula.

Niacinamide (vitamin B3) is a gentle skincare active that repairs the skin barrier, calms redness, controls oil and evens tone at 2–5%. Official IUPAC name: **3-Pyridinecarboxamide**

Soothing Anti-Aging Pore Minimizer
Panthenol Vitamin B5 (panthenol)

6th on the list, which puts it at an estimated 2–10% of the formula.

Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (2R)-; dl-Panthenol

Hydration Soothing

7th on the list, which puts it at an estimated 1–5% of the formula.

Decanoic acid, ester with 1,2,3-propanetriol octanoate; Glycerides, mixed decanoyl and octanoyl

Hydration

9th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Ammonium Acryloyldimethyltaurate/VP Copolymer is a copolymer of ammonium acryloyldimethyltaurate and vinylpyrrolidone monomers

Hydration

10th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Stearic acid, monoester with glycerol

Hydration

12th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Hexadecyl 2-ethylhexanoate

Hydration

17th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

L-Arginine

Hydration Anti-Aging

21st on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Cholest-5-en-3-ol (beta)-

Hydration Anti-Aging

29th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Urea, (2,5-dioxo-4-imidazolidinyl)-

Soothing

Formula analysis

Each axis is scored from the ingredients present and how high up the list they sit.

Hydration Very high

Ingredients that pull and hold water in the upper layers of skin

Barrier support Moderate

Lipids and repair signals that support skin barrier integrity

Antioxidant support None

Ingredients that mop up free radicals from UV and pollution

Oil control Moderate

Ingredients that moderate sebum or absorb shine

Brightening Low

Ingredients that act on uneven tone and post-inflammatory marks

Soothing Moderate

Ingredients aimed at visible redness and reactivity

Cell renewal None

Retinoids, acids and enzymes that speed surface turnover

Firmness signalling None

Peptides and growth factors that signal for collagen support

Active and supporting ingredients

"Active" here means an ingredient carrying a recorded active type or a recognised UV filter.

Active ingredients (4)

Supporting ingredients (46)

Solvents, emollients, texture agents and preservatives — the formula that carries the actives.

Water Methylpropanediol Glycerin 1,2-hexanediol Caprylic/capric Triglyceride Polypropylsilsesquioxane Ammonium Acryloyldimethyltaurate/vp Copolymer Glyceryl Stearate C14-22 Alcohols Cetyl Ethylhexanoate Macadamia Ternifolia Seed Oil Vinyl Dimethicone Sodium Acrylate/sodium Acryloyldimethyl Taurate Copolymer Acrylates/c10-30 Alkyl Acrylate Crosspolymer Arginine Brassica Campestris Sterols Polyglyceryl-10 Laurate Polyisobutene Cholesterol Hydrolyzed Sponge Phytosteryl/behenyl Dimer Dilinoleate Xanthan Gum C12-20 Alkyl Glucoside Lauryl Glucoside Polyglyceryl-6 Laurate Gardenia Florida Fruit Extract Allantoin Butyrospermum Parkii Butter Ethylhexylglycerin Helianthus Annuus Seed Oil Myristyl Glucoside Hydrogenated Lecithin Pentaerythrityl Tetra C5-9 Acid Esters Adenosine Dextrin Caprylyl/capryl Glucoside Polyglutamic Acid Sorbitan Oleate Disodium Edta Benzotriazolyl Dodecyl P-cresol Glyceryl Acrylate/acrylic Acid Copolymer Stearic Acid Oleic Acid Pvm/ma Copolymer Sodium DNA CI 40800

What is and is not in it

Read from the full ingredient list. A brand's own claim may differ.

Free from

  • Fragrance-free
  • Essential-oil-free
  • No drying alcohol
  • Paraben-free
  • Microplastic-free
  • Sulfate-free
  • No animal-derived ingredients

Contains

  • Silicones

    Polypropylsilsesquioxane, Vinyl Dimethicone

  • Added colour

    CI 40800

  • Facial oils

    Macadamia Ternifolia Seed Oil, Helianthus Annuus Seed Oil

What to layer it with

Judged by the same curated rules our routine checker uses. It reads the ingredients, not the label.

Compatible with

  • Retinoids (retinol, retinal)
  • Copper peptides
  • Bakuchiol
  • Niacinamide
  • Hyaluronic acid
  • Ceramides
  • Signal peptides
  • Panthenol
  • Sunscreen

Use with caution

  • AHAs (glycolic, lactic)

    Best kept to separate routines — one in the morning, one at night, or on alternate days.

  • BHA (salicylic acid)

    Best kept to separate routines — one in the morning, one at night, or on alternate days.

  • PHAs (gluconolactone)

    Best kept to separate routines — one in the morning, one at night, or on alternate days.

  • Benzoyl peroxide

    Best kept to separate routines — one in the morning, one at night, or on alternate days.

  • Vitamin C (L-ascorbic acid)

    Can be layered, but the combination raises the irritation risk. Go slowly.

  • Azelaic acid

    Can be layered, but the combination raises the irritation risk. Go slowly.

Where it fits in a routine

Morning Evening
  1. Cleanse
  2. Toning
  3. Treat
  4. Moisturise
  5. Protect

This product is the "Moisturise" step.

  • Seal in your serums with it; in the morning, sunscreen still goes on top.

Safety and suitability

Flags to check, not verdicts. None of this is medical advice — if you are pregnant, breastfeeding or treating a skin condition, ask a doctor.

Pregnancy and breastfeeding
Contains Retinol, usually reviewed with a doctor during pregnancy.
Fungal acne (malassezia)
8 ingredients could feed malassezia: Glyceryl Stearate, Macadamia Ternifolia Seed Oil, Polyglyceryl-10 Laurate, Phytosteryl/behenyl Dimer Dilinoleate, Polyglyceryl-6 Laurate, Butyrospermum Parkii Butter, Helianthus Annuus Seed Oil, Sorbitan Oleate. That is about the yeast's food supply, not a prediction that you will break out.
Sensitive and reactive skin
No ingredient in this formula carries a common-irritant flag, making it a reasonable option for reactive skin. A patch test is still recommended, as individual skin reactivity varies.
Recorded ingredient risks
Pregnancy Unsafe, Silicone, Synthetic polymer

Ingredients by function

Most ingredients do more than one job, so these counts add up to more than the 50 ingredients on the label.

16
Texture agent

Sets the thickness, spread and stability of the formula

12
Surfactant

Lifts oil and dirt, or holds oil and water together

8
Emollient

Softens and smooths by filling gaps between skin cells

7
Occlusive

Forms a film that slows water loss

4
Active

Changes how skin behaves rather than how it feels

4
Solvent

Dissolves and carries everything else

2
Humectant

Draws water into the upper layers of skin

1
Fragrance / colour

Changes how the product smells or looks

1
Soothing

Calms visible redness and irritation

1
Chelator

Binds trace metals that would otherwise spoil the formula

1
Plant extract

Botanical material, usually for antioxidants or scent

1
UV filter

Absorbs or scatters ultraviolet light

Ingredient breakdown

Every ingredient on the label, in order, with what it does and roughly how much of it is likely to be there.

1 Water Solvent
Estimated level
30–80%
Confidence
Moderate — INCI order above the 1% line
Roles
Solvent

1st on the list, which puts it at an estimated 30–80% of the formula.

Aqua (EU),Deionized Water,Distilled Water,Micromatrix Fractile AN,Onsen-Sui (JPN),Purified Water

Hydration
3 scientific references
  • Skin Research and Technology, May 2015, pages 131-136
  • Skin Pharmacology and Applied Skin Physiology, November-December 1999, pages 344-351
  • Journal of Cosmetic Science, September-October 1993, pages 249-262
Estimated level
5–20%
Confidence
Moderate — INCI order above the 1% line
Roles
Solvent

2nd on the list, which puts it at an estimated 5–20% of the formula.

2-Methyl-1,3-propanediol

Hydration
3 scientific references
  • PubChem, Accessed April 2021, ePublication
  • Cosmetic Ingredient Review, June 2018, pages 1-73
  • Contact Dermatitis, September 2017, pages 159-162
3 Glycerin Humectant
Estimated level
5–20%
Confidence
Moderate — INCI order above the 1% line
Roles
Humectant, Occlusive, Texture agent, Solvent

3rd on the list, which puts it at an estimated 5–20% of the formula.

Glycerine ;Glycerol (INN); Glycerol (RIFM); Glycerolum (EP); Glycyl Alcohol; 1,2,3-Propanetriol; 1,2,3-Trihydroxypropane

Hydration Anti-Aging
6 scientific references
  • Journal of Pharmaceutical Investigation, March 2021, pages 223-231
  • International Journal of Toxicology, November/December 2019, Volume 38, Supplement 3, pages 6S-22S
  • International Journal of Cosmetic Science, August 2016, ePublication
  • British Journal of Dermatology, July 2008, pages 23-34
  • Journal of Cosmetic Dermatology, June 2007, pages 75-82
  • Proceedings of the National Academy of Sciences, June 2003, pages 7, 360-7, 365
Estimated level
2–10%
Confidence
Moderate — INCI order above the 1% line
Roles
Solvent

4th on the list, which puts it at an estimated 2–10% of the formula.

5 Niacinamide Active
Estimated level
2–10%
Confidence
Moderate — INCI order above the 1% line
Roles
Active

5th on the list, which puts it at an estimated 2–10% of the formula.

Niacinamide (vitamin B3) is a gentle skincare active that repairs the skin barrier, calms redness, controls oil and evens tone at 2–5%. Official IUPAC name: **3-Pyridinecarboxamide**

Soothing Anti-Aging Pore Minimizer
15 scientific references
  • International Journal of Dermatology, February 2021, pages 166-173
  • Biomolecules & Therapeutics, July 2019, pages 562-569
  • Experimental Dermatology, February 2019, pages 15-22
  • Dermatologic Therapy, September 2017, ePublication
  • Journal of Investigative Dermatology, May 2017, page S116
  • International Journal of Pharmaceutics, March 2017, pages 158-162
  • Facial Plastic Surgery Clinics of North America, May 2016, pages 145-152
  • Clinical, Cosmetic, and Investigational Dermatology, July 2015, pages 405-412
  • Skin Pharmacology and Physiology, June 2014, pages 311-315
  • International Journal of Pharmacy, January 2013, pages 192-201
  • Dermatoendrocrinology, July 2012, pages 308-319
  • International Journal of Toxicology, September 2005, pages 1-31
  • Dermatologic Surgery, July 2005, pages 860-865
  • International Journal of Cosmetic Science, October 2004, pages 231-238
  • Journal of Cosmetic Dermatology, April 2004, pages 88-93
6 Panthenol Active
Estimated level
2–10%
Confidence
Moderate — INCI order above the 1% line
Roles
Active

6th on the list, which puts it at an estimated 2–10% of the formula.

Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (2R)-; dl-Panthenol

Hydration Soothing
7 scientific references
  • The Linus Pauling Institute, Oregon State University, Accessed April 2021, ePublication
  • International Journal of Cosmetic Science, December 2019, pages 534-547
  • Journal of Cosmetic Dermatology, January 2019, pages 346-354
  • Cosmetic Ingredient Review, March 2018, pages 1-51
  • The Journal of Dermatological Treatment, August 2017, pages 173-180
  • Journal of Cosmetic Science, August 2011, pages 361-370
  • American Journal of Clinical Dermatology, Volume 3, 2002, pages 427-433
Estimated level
1–5%
Confidence
Moderate — INCI order above the 1% line

7th on the list, which puts it at an estimated 1–5% of the formula.

Decanoic acid, ester with 1,2,3-propanetriol octanoate; Glycerides, mixed decanoyl and octanoyl

Hydration
5 scientific references
  • International Journal of Toxicology, September 2020, pages 34-35
  • Periodica Polytechnica Chemical Engineering, 2014, pages 43-48
  • International Journal of Toxicology, January 2003, pages 4-5
  • Food and Chemical Toxicology, January 2000, pages 79-98
  • Journal of the Society of Cosmetic Chemists, August 1985, pages 303-311
Estimated level
1–5%
Confidence
Moderate — INCI order above the 1% line
Roles
Occlusive

8th on the list, which puts it at an estimated 1–5% of the formula.

Polymer formed by hydrolysis and condensation of propyltrichlorosilane

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Texture agent

9th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Ammonium Acryloyldimethyltaurate/VP Copolymer is a copolymer of ammonium acryloyldimethyltaurate and vinylpyrrolidone monomers

Hydration
10 Glyceryl Stearate Emollient
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Emollient, Surfactant

10th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Stearic acid, monoester with glycerol

Hydration
3 scientific references
  • Cosmeticsinfoorg, Accessed November 2021, ePublication
  • Drugs in Context, April 2018, pages 1-14
  • International Journal of Toxicology, May 2007, pages 1–30
11 C14-22 Alcohols Texture agent
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Texture agent

11th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

C14-22 Alcohols is a mixture of synthetic fatty alcohols with 14 to 22 carbons in the alkyl chain

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Emollient

12th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Hexadecyl 2-ethylhexanoate

Hydration
2 scientific references
  • Engineering in Life Sciences, March 2019, pages 370-388
  • International Journal of Toxicology, Nov-Dec 2015, pages 61S-73S
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Emollient

13th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Macadamia Ternifolia Seed Oil is the fixed oil obtained from the nuts of the Bushnut, Macadamia ternifolia, Proteaceae. It consists primarily of the glycerides of the fatty acids

14 Vinyl Dimethicone Texture agent
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Texture agent

14th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Silicones and siloxanes, dimethyl, ethenyl methyl, ethenyldimethylsilyl terminated

Silicone
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Occlusive, Texture agent

15th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer is a copolymer of sodium acrylate and sodium acryloyldimethyl taurate monomers

Synthetic polymer
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Occlusive, Texture agent

16th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

C10-30 alkyl propenoate, polymer with propenoic acid, butenoic acidand/or alkyl propenoates, product with propenyl sucrose ether or propenyl 2,2-dihydroxymethyl-1,3-propanediol

Synthetic polymer
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

17th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

L-Arginine

Hydration Anti-Aging
6 scientific references
  • Biobased Surfactants (Second Edition), 2019, pages 413-445
  • Scientific Reports, February 2016, pages 1-10
  • Cosmetic Ingredient Review, October 2012, pages 1-35
  • Journal of Advanced Research, July 2010, pages 169–177
  • International Journal of Cosmetic Science, April 2005, page 139
  • Wound Repair and Regeneration, November-December 2003, pages 419-423
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Emollient

18th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Brassica Campestris Sterols is a mixture of sterols obtained from the Cabbage, Brassica campestris L., Brassicaceae

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

19th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

1,2,3-Propanetriol, homopolymer, dodecanoates (1:1) (10 mol glycerol average molar ratio)

20 Polyisobutene Occlusive
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Occlusive, Texture agent

20th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Homopolymer of 2-methyl-1 propene

21 Cholesterol Emollient
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Emollient, Surfactant, Texture agent

21st on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Cholest-5-en-3-ol (beta)-

Hydration Anti-Aging
4 scientific references
  • Frontiers in Bioengineering and Biotechnology, August 2015, pages 1-6
  • Journal of Cosmetic Dermatology, July 2007, pages 239-242
  • Journal of Structural Biology, June 2007, pages 386-400
  • International Journal of Toxicology, 2006, pages 1-89
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

22nd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Hydrolyzed Sponge is the hydrolysate of sponge obtained by acid, enzyme or other method of hydrolysis

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Texture agent

23rd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

9,12(Z,Z)-Octadecadienoic acid dimer, diester with plant sterols and docosanol

24 Xanthan Gum Surfactant
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Surfactant, Texture agent

24th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Xanthan gum

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Surfactant

25th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

C12-20 Alkyl Glucoside is the product obtained by the condensation of C12-20 alcohols with glucose

26 Lauryl Glucoside Surfactant
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Surfactant

26th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

D-Glucose homopolymer, dodecyl ether

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Surfactant

27th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

1,2,3-Propanetriol, homopolymer, dodecanoates (1:1) (6 mol glycerol average molar ratio)

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Plant extract

28th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Gardenia Florida Fruit Extract is an extract of the fruit of the Cape Jasmine, Gardenia Florida L., Rubiaceae

29 Allantoin Occlusive
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Occlusive, Soothing

29th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Urea, (2,5-dioxo-4-imidazolidinyl)-

Soothing
8 scientific references
  • Chemistry Series, March 2020, pages 7-21
  • Molecules, June 2019, pages 1-33
  • European Journal of Pharmacology, February 2018, pages 68-78
  • Journal of the American Academy of Dermatology, June 2017, Volume 76, Issue 2, Supplement 1
  • Pharmacognosy Review, Volume 5, July-December 2011
  • International Journal of Toxicology, May 2010, Supplement, pages 84S-97S
  • Journal of Occupational Medicine and Toxicology, October 2008, ePublication
  • https://wwwaccessdatafdagov/scripts/cdrh/cfdocs/cfcfr/CFRSearchcfm?CFRPart=347&showFR=1
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Texture agent

30th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Butyrospermum Parkii Butter is the fat obtained from the fruit of the Shea Tree, Butyrospernum parkii, Sapotaceae

Anti-Aging Hydration Soothing
3 scientific references
  • Journal of Clinical and Aesthetic Dermatology, June 2011, pages 45-55
  • Journal of Agricultural and Food Chemistry, October 2003, pages 6, 268-6, 273
  • Journal of Allergy and Clinical Immunology, February 2009, page S41
31 Retinol Active
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Active

31st on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Retinol; vitamin A

Anti-Aging Anti-Acne Pore Minimizer Pregnancy Unsafe
10 scientific references
  • Journal of Drugs in Dermatology, September 2019, pages 918-923; and March 2015, pages 271-280
  • Experimental Dermatology, August 2019, pages 906-913
  • Archives of Dermatological Research, May 2017, pages 275-283
  • International Journal of Cosmetic Science, February 2017, pages 56-65
  • Dermatology, May 2014, pages 314-325
  • Dermatoendocrinology, July 2012, issue 3, pages 308-319
  • Toxicological Research, March 2010, pages 61-66
  • Archives of Dermatology, May 2007, pages 606-612
  • The Journal of Pathology, January 2007, issue 2, pages 241-251
  • Clinical Interventions in Aging, December 2006, pages 327-348
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

32nd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

1,2-Propanediol, 3-(2-ethylhexyloxy)

Hydration
5 scientific references
  • PLoS One, October 2016, ePublication
  • Contact Dermatitis, May 2016, pages 281-288
  • International Journal of Toxicology, September 2013, pages 5S-21S
  • Personal Care, 2008, pages 1-4
  • Cosmetic Science Technology, 2006, pages 1-11
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Emollient

33rd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Helianthus Annuus Seed Oil is the oil expressed from the seeds of the Sunflower, Helianthus annuus L., Compositae

Anti-Aging Hydration
4 scientific references
  • Pediatric Dermatology, August 2018, ePublication; and January-February 2013, pages 42-50
  • Chemicke Zvesti, May 2018, pages 2, 607-2, 615
  • International Journal of Molecular Sciences, December 2017, ePublication
  • Dermatology, October 2014, pages 230-239
34 Myristyl Glucoside Surfactant
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Surfactant

34th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Tetradecyl D-glucopyranoside

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Surfactant

35th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Lecithins, hydrogenated

Hydration
4 scientific references
  • International Journal of Toxicology, September 2020, pages 5S-25S
  • Nanocosmetics, June 2019, pages 95–140
  • Current Drug Delivery, 2016, pages 111–120
  • Pharmaceutical Research, February 2013, pages 538–55
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

36th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Carboxylic acids, C5-9, tetraesters with pentaerythritol

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

37th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

6-Amino-9-beta-D-ribofuranosyl-9H-purine

Soothing
8 scientific references
  • PubChem, Accessed May 2021, ePublication
  • Cosmetic Ingredient Review, September 2020, pages 1-38
  • Experimental Dermatology, August 2014, pages 553-554
  • Journal of Investigative Dermatology, August 2011, pages 526-546
  • International Journal of Cosmetic Science, December 2006, pages 447-451
  • British Journal of Pharmacology, October 2008, issue 4, pages 475-486
  • PloS One, May 2008 (ePublication)
  • >International Journal of Cosmetic Science, August 2006, pages 447-451
38 Dextrin Texture agent
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Texture agent

38th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Dextrin

Oil Control
8 scientific references
  • Oil-Absorbing Ingredients
  • Help for Oily Skin
  • Salicylic Acid for Skin
  • How BHA Exfoliants Work
  • Which BHA Exfoliant is Right for Me?
  • Niacinamide Benefits: What Does Niacinamide Do for Skin?
  • The Best Toners for Oily Skin
  • The Best Moisturizers for Oily, Acne-Prone Skin
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Surfactant

39th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

D-Glucopyranose, oligomers, decyl octyl glycosides

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

40th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Polymer of glutamic acid

Hydration Anti-Aging
5 scientific references
  • Biomass Conversion and Biorefinery, March 2021, ePublication
  • Molecules, July 2020, pages 1–33
  • Journal of Materials Science, Materials in Medicine, Volume 31, May 2020, ePublication
  • Journal of Biomedical Materials Research, November 2017, pages
  • Saudi Journal of Biological Sciences, April 2014, pages 153–158
41 Sorbitan Oleate Surfactant
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Surfactant

41st on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Sorbitan oleate

42 Disodium Edta Texture agent
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Texture agent, Chelator

42nd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Disodium dihydrogen ethylenediaminetetraacetate

43 Ceramide NP Active
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Active

43rd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Ceramide NP,1,3,4-Octadecanetriol, 2-Octadecanamide,Stearoyl-C18-Phytosphingosine,Stearoyl-4-Hydroxysphinganine

Hydration Anti-Aging
11 scientific references
  • International Journal of Toxicology, 2020, pages 5S-25S
  • International Journal of Molecular Sciences, August 2019, pages 1-15
  • Skin Pharmacology and Physiology, 2016, pages 135-147
  • Biochimica et Biophysica Acta, October 2014, pages 2473-2483
  • Journal of the American Academy of Dermatology, July 2014, pages 177-184
  • Journal of Lipid Research, July 2008, pages 1, 466-1, 476
  • Journal of Lipid Research, September 2007, pages 1936-1943
  • American Journal of Clinical Dermatology, 2003, pages 107-129
  • Contact Dermatitis, June 2002, pages 331-338
  • Journal of Investigative Dermatology, November 2001, pages 1, 126-1, 136
  • Skin Pharmacology and Applied Skin Physiology, September-October 2001, pages 261-271
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
UV filter

44th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Phenol, 2-(2H-Benzotriazol-2-yl)-6-Dodecyl-4-Methyl-, Branched and Linear

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Humectant, Texture agent

45th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Glyceryl Acrylate/Acrylic Acid Copolymer is a copolymer of glyceryl acrylate and acrylic acid

Synthetic polymer
46 Stearic Acid Emollient
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Emollient, Surfactant, Texture agent

46th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Stearic acid

Hydration
4 scientific references
  • Cosmetic Ingredient Review, May 2019, pages 1-61
  • International Journal of Cosmetic Science, August 2008, page 310
  • Therapeutics for the Clinician, May 2005, pages 317-324
  • Journal of Cosmetic Science, December 2003, pages 559-568
47 Oleic Acid Emollient
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Emollient, Surfactant

47th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

9-Octadecenoic acid (9Z)-

48 Pvm/ma Copolymer Occlusive
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Occlusive, Texture agent

48th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

2,5-Furandione, polymer with methoxyethene; copolymer of methyl vinyl ether and maleic anhydride

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

49th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Deoxyribonucleic acid, sodium salts

50 CI 40800 Fragrance / colour
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Fragrance / colour

50th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

beta Carotene

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Frequently asked questions

What ingredients are in Spicule Retinol PDRN Cream?

WATER, METHYLPROPANEDIOL, GLYCERIN, 1,2-HEXANEDIOL, NIACINAMIDE, PANTHENOL, CAPRYLIC/CAPRIC TRIGLYCERIDE, POLYPROPYLSILSESQUIOXANE, AMMONIUM ACRYLOYLDIMETHYLTAURATE/VP COPOLYMER, GLYCERYL STEARATE, C14-22 ALCOHOLS, CETYL ETHYLHEXANOATE, MACADAMIA TERNIFOLIA SEED OIL, VINYL DIMETHICONE, SODIUM ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER, ACRYLATES/C10-30 ALKYL ACRYLATE CROSSPOLYMER, ARGININE, BRASSICA CAMPESTRIS STEROLS, POLYGLYCERYL-10 LAURATE, POLYISOBUTENE, CHOLESTEROL, HYDROLYZED SPONGE, PHYTOSTERYL/BEHENYL DIMER DILINOLEATE, XANTHAN GUM, C12-20 ALKYL GLUCOSIDE, LAURYL GLUCOSIDE, POLYGLYCERYL-6 LAURATE, GARDENIA FLORIDA FRUIT EXTRACT, ALLANTOIN, BUTYROSPERMUM PARKII BUTTER, RETINOL, ETHYLHEXYLGLYCERIN, HELIANTHUS ANNUUS SEED OIL, MYRISTYL GLUCOSIDE, HYDROGENATED LECITHIN, PENTAERYTHRITYL TETRA C5-9 ACID ESTERS, ADENOSINE, DEXTRIN, CAPRYLYL/CAPRYL GLUCOSIDE, POLYGLUTAMIC ACID, SORBITAN OLEATE, DISODIUM EDTA, CERAMIDE NP, BENZOTRIAZOLYL DODECYL P-CRESOL, GLYCERYL ACRYLATE/ACRYLIC ACID COPOLYMER, STEARIC ACID, OLEIC ACID, PVM/MA COPOLYMER, SODIUM DNA, CI 40800.

What are the active ingredients in Spicule Retinol PDRN Cream?

NIACINAMIDE, PANTHENOL, RETINOL, CERAMIDE NP.

How do I use Spicule Retinol PDRN Cream?

Apply a small amount to clean, dry skin in the evening. Start 2–3 times per week and gradually increase frequency. Follow with moisturizer if needed. Use sunscreen during the day.

What skin types is Spicule Retinol PDRN Cream good for?

Judged on how rich the formula reads from its ingredient list, it suits Balanced skin best. It is the least natural fit for Dry, Combination (dry) skin.

Is Spicule Retinol PDRN Cream good for sensitive skin?

No ingredient in this formula carries a common-irritant flag, making it a reasonable option for reactive skin. A patch test is still recommended, as individual skin reactivity varies.

Is Spicule Retinol PDRN Cream fungal acne safe?

8 ingredients could feed malassezia: Glyceryl Stearate, Macadamia Ternifolia Seed Oil, Polyglyceryl-10 Laurate, Phytosteryl/behenyl Dimer Dilinoleate, Polyglyceryl-6 Laurate, Butyrospermum Parkii Butter, Helianthus Annuus Seed Oil, Sorbitan Oleate. That describes the yeast's food supply, not a prediction that they will cause a breakout.

Can I use Spicule Retinol PDRN Cream while pregnant?

It contains Retinol, which are usually reviewed with a doctor during pregnancy. Ask your doctor or midwife before using it.

Is Spicule Retinol PDRN Cream fragrance free?

Yes. Reading the full ingredient list, this formula is fragrance-free.

Does Spicule Retinol PDRN Cream contain alcohol?

No. Reading the full ingredient list, this formula is no drying alcohol.

Is Spicule Retinol PDRN Cream silicone free?

No — it contains Polypropylsilsesquioxane, Vinyl Dimethicone.

Does Spicule Retinol PDRN Cream contain essential oils?

No. Reading the full ingredient list, this formula is essential-oil-free.

Is Spicule Retinol PDRN Cream paraben free?

Yes. Reading the full ingredient list, this formula is paraben-free.

What can I layer with Spicule Retinol PDRN Cream?

It layers well with Retinoids (retinol, retinal), Copper peptides, Bakuchiol, Niacinamide, Hyaluronic acid, Ceramides. Take more care combining it with AHAs (glycolic, lactic), BHA (salicylic acid), PHAs (gluconolactone), Benzoyl peroxide, Vitamin C (L-ascorbic acid), Azelaic acid — use them in separate routines or on alternate days.

When should I apply Spicule Retinol PDRN Cream?

Use it morning and evening, after serums.

How many ingredients does Spicule Retinol PDRN Cream have?

It lists 50 ingredients, of which 4 are recorded as actives.

Who makes Spicule Retinol PDRN Cream?

Mary&May, a brand based in Korea.

Brand
Mary&May
Country
Korea

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