1st on the list, which puts it at an estimated 30–80% of the formula.
Aqua (EU),Deionized Water,Distilled Water,Micromatrix Fractile AN,Onsen-Sui (JPN),Purified Water
Mary&May
Spicule Retinol PDRN Cream
face cream
Mary&May
face cream
Added Last edited
Fit by skin type
General, ingredient-based — not your personalized match.
See how this fits your skin
Take the skin test and I'll show you how suitable this product is for you.
Take the skin testThe Mary&May Spicule Retinol PDRN Cream is an advanced anti-aging moisturizer designed to improve skin texture, boost elasticity, and support visible skin regeneration. This high-performance formula enhances the delivery of active ingredients while promoting skin renewal. It works to smooth fine lines, refine pores, and improve overall skin firmness.
Spicule Retinol PDRN Cream is a lightweight cream from Mary&May, a brand based in Korea. The formula is built mainly around hydration. The ingredient list runs to 50 ingredients, each broken down in full below.
By its ingredient list the formula reads as light: water and humectants lead, with emollients kept lower in the order. It contains both silicones and oils, a combination that usually finishes smooth and slightly satin and sits well under makeup. Hydration is handled by Methylpropanediol, Glycerin and Panthenol, humectants that pull water into the upper layers of skin rather than sealing it there.
Hydration: Very high. Ingredients that pull and hold water in the upper layers of skin, and here that comes from Methylpropanediol, Glycerin, Panthenol and Ethylhexylglycerin.
Barrier support: Moderate. Lipids and repair signals that support skin barrier integrity, and here that comes from Niacinamide, Panthenol, Cholesterol and Butyrospermum Parkii Butter.
Soothing: Moderate. Ingredients aimed at visible redness and reactivity, and here that comes from Panthenol, Cetyl Ethylhexanoate, Allantoin and Niacinamide.
Oil control: Moderate. Ingredients that moderate sebum or absorb shine, and here that comes from Niacinamide, Retinol and Dextrin.
On richness alone it suits Balanced skin best, and is the least natural fit for Dry and Combination (dry) skin. Nothing in the list is flagged as a common irritant, which is a reasonable starting point for reactive skin — though a patch test is still the only way to know.
The formula contributes little or nothing on antioxidant protection, cell renewal and firmness signalling. That is not a fault — most products are not meant to do everything — but if one of those is your priority, this is not the product that will address it.
Reading the full list, the formula is fragrance-free, essential-oil-free, no drying alcohol, paraben-free, microplastic-free and sulfate-free. Those claims come from the ingredient list itself, not from the packaging.
It can be used morning and evening. In a routine it goes after serums. Seal in your serums with it; in the morning, sunscreen still goes on top.
This summary is generated from the product's ingredient list. It is not a review, it is not the brand's own marketing claims, and it does not replace advice from a dermatologist.
Drawn purely from the ingredient list
Scored on how rich or light the formula reads from its INCI order.
No ingredient in this formula carries a common-irritant flag, making it a reasonable option for reactive skin. A patch test is still recommended, as individual skin reactivity varies.
Based on the curated benefits documented for this product's ingredients.
Attracts and locks in moisture to keep skin plump and dewy
Boosts collagen and cell turnover to reduce fine lines and wrinkles
Calms redness, irritation, and inflammation for sensitive skin
Tightens and refines the look of enlarged pores
Targets breakouts by reducing bacteria and unclogging pores
Regulates sebum production to reduce shine and greasiness
None of the ingredients in this formula are associated with these benefits. This is not unusual, as most products are designed to target a limited number of concerns.
The actives, UV filters and benefit-carrying ingredients in this formula, in the order they are listed.
1st on the list, which puts it at an estimated 30–80% of the formula.
Aqua (EU),Deionized Water,Distilled Water,Micromatrix Fractile AN,Onsen-Sui (JPN),Purified Water
2nd on the list, which puts it at an estimated 5–20% of the formula.
2-Methyl-1,3-propanediol
3rd on the list, which puts it at an estimated 5–20% of the formula.
Glycerine ;Glycerol (INN); Glycerol (RIFM); Glycerolum (EP); Glycyl Alcohol; 1,2,3-Propanetriol; 1,2,3-Trihydroxypropane
5th on the list, which puts it at an estimated 2–10% of the formula.
Niacinamide (vitamin B3) is a gentle skincare active that repairs the skin barrier, calms redness, controls oil and evens tone at 2–5%. Official IUPAC name: **3-Pyridinecarboxamide**
6th on the list, which puts it at an estimated 2–10% of the formula.
Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (2R)-; dl-Panthenol
7th on the list, which puts it at an estimated 1–5% of the formula.
Decanoic acid, ester with 1,2,3-propanetriol octanoate; Glycerides, mixed decanoyl and octanoyl
9th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Ammonium Acryloyldimethyltaurate/VP Copolymer is a copolymer of ammonium acryloyldimethyltaurate and vinylpyrrolidone monomers
10th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Stearic acid, monoester with glycerol
12th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Hexadecyl 2-ethylhexanoate
17th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
L-Arginine
21st on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Cholest-5-en-3-ol (beta)-
29th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Urea, (2,5-dioxo-4-imidazolidinyl)-
Each axis is scored from the ingredients present and how high up the list they sit.
Ingredients that pull and hold water in the upper layers of skin
Lipids and repair signals that support skin barrier integrity
Ingredients that mop up free radicals from UV and pollution
Ingredients that moderate sebum or absorb shine
Ingredients that act on uneven tone and post-inflammatory marks
Ingredients aimed at visible redness and reactivity
Retinoids, acids and enzymes that speed surface turnover
Peptides and growth factors that signal for collagen support
"Active" here means an ingredient carrying a recorded active type or a recognised UV filter.
Solvents, emollients, texture agents and preservatives — the formula that carries the actives.
Read from the full ingredient list. A brand's own claim may differ.
Polypropylsilsesquioxane, Vinyl Dimethicone
CI 40800
Macadamia Ternifolia Seed Oil, Helianthus Annuus Seed Oil
Judged by the same curated rules our routine checker uses. It reads the ingredients, not the label.
Best kept to separate routines — one in the morning, one at night, or on alternate days.
Best kept to separate routines — one in the morning, one at night, or on alternate days.
Best kept to separate routines — one in the morning, one at night, or on alternate days.
Best kept to separate routines — one in the morning, one at night, or on alternate days.
Can be layered, but the combination raises the irritation risk. Go slowly.
Can be layered, but the combination raises the irritation risk. Go slowly.
This product is the "Moisturise" step.
Flags to check, not verdicts. None of this is medical advice — if you are pregnant, breastfeeding or treating a skin condition, ask a doctor.
Most ingredients do more than one job, so these counts add up to more than the 50 ingredients on the label.
Sets the thickness, spread and stability of the formula
Lifts oil and dirt, or holds oil and water together
Softens and smooths by filling gaps between skin cells
Forms a film that slows water loss
Changes how skin behaves rather than how it feels
Dissolves and carries everything else
Draws water into the upper layers of skin
Changes how the product smells or looks
Calms visible redness and irritation
Binds trace metals that would otherwise spoil the formula
Botanical material, usually for antioxidants or scent
Absorbs or scatters ultraviolet light
Every ingredient on the label, in order, with what it does and roughly how much of it is likely to be there.
1st on the list, which puts it at an estimated 30–80% of the formula.
Aqua (EU),Deionized Water,Distilled Water,Micromatrix Fractile AN,Onsen-Sui (JPN),Purified Water
2nd on the list, which puts it at an estimated 5–20% of the formula.
2-Methyl-1,3-propanediol
3rd on the list, which puts it at an estimated 5–20% of the formula.
Glycerine ;Glycerol (INN); Glycerol (RIFM); Glycerolum (EP); Glycyl Alcohol; 1,2,3-Propanetriol; 1,2,3-Trihydroxypropane
4th on the list, which puts it at an estimated 2–10% of the formula.
5th on the list, which puts it at an estimated 2–10% of the formula.
Niacinamide (vitamin B3) is a gentle skincare active that repairs the skin barrier, calms redness, controls oil and evens tone at 2–5%. Official IUPAC name: **3-Pyridinecarboxamide**
6th on the list, which puts it at an estimated 2–10% of the formula.
Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (2R)-; dl-Panthenol
7th on the list, which puts it at an estimated 1–5% of the formula.
Decanoic acid, ester with 1,2,3-propanetriol octanoate; Glycerides, mixed decanoyl and octanoyl
8th on the list, which puts it at an estimated 1–5% of the formula.
Polymer formed by hydrolysis and condensation of propyltrichlorosilane
9th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Ammonium Acryloyldimethyltaurate/VP Copolymer is a copolymer of ammonium acryloyldimethyltaurate and vinylpyrrolidone monomers
10th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Stearic acid, monoester with glycerol
11th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
C14-22 Alcohols is a mixture of synthetic fatty alcohols with 14 to 22 carbons in the alkyl chain
12th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Hexadecyl 2-ethylhexanoate
13th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Macadamia Ternifolia Seed Oil is the fixed oil obtained from the nuts of the Bushnut, Macadamia ternifolia, Proteaceae. It consists primarily of the glycerides of the fatty acids
14th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Silicones and siloxanes, dimethyl, ethenyl methyl, ethenyldimethylsilyl terminated
15th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer is a copolymer of sodium acrylate and sodium acryloyldimethyl taurate monomers
16th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
C10-30 alkyl propenoate, polymer with propenoic acid, butenoic acidand/or alkyl propenoates, product with propenyl sucrose ether or propenyl 2,2-dihydroxymethyl-1,3-propanediol
17th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
L-Arginine
18th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Brassica Campestris Sterols is a mixture of sterols obtained from the Cabbage, Brassica campestris L., Brassicaceae
19th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
1,2,3-Propanetriol, homopolymer, dodecanoates (1:1) (10 mol glycerol average molar ratio)
20th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Homopolymer of 2-methyl-1 propene
21st on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Cholest-5-en-3-ol (beta)-
22nd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Hydrolyzed Sponge is the hydrolysate of sponge obtained by acid, enzyme or other method of hydrolysis
23rd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
9,12(Z,Z)-Octadecadienoic acid dimer, diester with plant sterols and docosanol
24th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Xanthan gum
25th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
C12-20 Alkyl Glucoside is the product obtained by the condensation of C12-20 alcohols with glucose
26th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
D-Glucose homopolymer, dodecyl ether
27th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
1,2,3-Propanetriol, homopolymer, dodecanoates (1:1) (6 mol glycerol average molar ratio)
28th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Gardenia Florida Fruit Extract is an extract of the fruit of the Cape Jasmine, Gardenia Florida L., Rubiaceae
29th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Urea, (2,5-dioxo-4-imidazolidinyl)-
30th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Butyrospermum Parkii Butter is the fat obtained from the fruit of the Shea Tree, Butyrospernum parkii, Sapotaceae
31st on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Retinol; vitamin A
32nd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
1,2-Propanediol, 3-(2-ethylhexyloxy)
33rd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Helianthus Annuus Seed Oil is the oil expressed from the seeds of the Sunflower, Helianthus annuus L., Compositae
34th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Tetradecyl D-glucopyranoside
35th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Lecithins, hydrogenated
36th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Carboxylic acids, C5-9, tetraesters with pentaerythritol
37th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
6-Amino-9-beta-D-ribofuranosyl-9H-purine
38th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Dextrin
39th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
D-Glucopyranose, oligomers, decyl octyl glycosides
40th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Polymer of glutamic acid
41st on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Sorbitan oleate
42nd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Disodium dihydrogen ethylenediaminetetraacetate
43rd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Ceramide NP,1,3,4-Octadecanetriol, 2-Octadecanamide,Stearoyl-C18-Phytosphingosine,Stearoyl-4-Hydroxysphinganine
44th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Phenol, 2-(2H-Benzotriazol-2-yl)-6-Dodecyl-4-Methyl-, Branched and Linear
45th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Glyceryl Acrylate/Acrylic Acid Copolymer is a copolymer of glyceryl acrylate and acrylic acid
46th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Stearic acid
47th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
9-Octadecenoic acid (9Z)-
48th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
2,5-Furandione, polymer with methoxyethene; copolymer of methyl vinyl ether and maleic anhydride
49th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
Deoxyribonucleic acid, sodium salts
50th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.
beta Carotene
Products in the same category that share this formula's distinguishing ingredients.
Mary&May
Shares 13 key ingredients with Spicule Retinol PDRN Cream: Water, Methylpropanediol, Glycerin, Caprylic/capric Triglyceride, Niacinamide
Centellian24
Shares 11 key ingredients with Spicule Retinol PDRN Cream: Water, Caprylic/capric Triglyceride, Glycerin, Glyceryl Stearate, Niacinamide
Numbuzin
Shares 11 key ingredients with Spicule Retinol PDRN Cream: Water, Glycerin, Niacinamide, Cetyl Ethylhexanoate, Methylpropanediol
Dr. Ceuracle
Shares 11 key ingredients with Spicule Retinol PDRN Cream: Water, Cetyl Ethylhexanoate, Niacinamide, Caprylic/capric Triglyceride, Glycerin
SOME BY MI
Shares 11 key ingredients with Spicule Retinol PDRN Cream: Water, Methylpropanediol, Glycerin, Niacinamide, Ammonium Acryloyldimethyltaurate/vp Copolymer
VT Cosmetics
Shares 11 key ingredients with Spicule Retinol PDRN Cream: Water, Glycerin, Methylpropanediol, Cetyl Ethylhexanoate, Caprylic/capric Triglyceride
WATER, METHYLPROPANEDIOL, GLYCERIN, 1,2-HEXANEDIOL, NIACINAMIDE, PANTHENOL, CAPRYLIC/CAPRIC TRIGLYCERIDE, POLYPROPYLSILSESQUIOXANE, AMMONIUM ACRYLOYLDIMETHYLTAURATE/VP COPOLYMER, GLYCERYL STEARATE, C14-22 ALCOHOLS, CETYL ETHYLHEXANOATE, MACADAMIA TERNIFOLIA SEED OIL, VINYL DIMETHICONE, SODIUM ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER, ACRYLATES/C10-30 ALKYL ACRYLATE CROSSPOLYMER, ARGININE, BRASSICA CAMPESTRIS STEROLS, POLYGLYCERYL-10 LAURATE, POLYISOBUTENE, CHOLESTEROL, HYDROLYZED SPONGE, PHYTOSTERYL/BEHENYL DIMER DILINOLEATE, XANTHAN GUM, C12-20 ALKYL GLUCOSIDE, LAURYL GLUCOSIDE, POLYGLYCERYL-6 LAURATE, GARDENIA FLORIDA FRUIT EXTRACT, ALLANTOIN, BUTYROSPERMUM PARKII BUTTER, RETINOL, ETHYLHEXYLGLYCERIN, HELIANTHUS ANNUUS SEED OIL, MYRISTYL GLUCOSIDE, HYDROGENATED LECITHIN, PENTAERYTHRITYL TETRA C5-9 ACID ESTERS, ADENOSINE, DEXTRIN, CAPRYLYL/CAPRYL GLUCOSIDE, POLYGLUTAMIC ACID, SORBITAN OLEATE, DISODIUM EDTA, CERAMIDE NP, BENZOTRIAZOLYL DODECYL P-CRESOL, GLYCERYL ACRYLATE/ACRYLIC ACID COPOLYMER, STEARIC ACID, OLEIC ACID, PVM/MA COPOLYMER, SODIUM DNA, CI 40800.
NIACINAMIDE, PANTHENOL, RETINOL, CERAMIDE NP.
Apply a small amount to clean, dry skin in the evening. Start 2–3 times per week and gradually increase frequency. Follow with moisturizer if needed. Use sunscreen during the day.
Judged on how rich the formula reads from its ingredient list, it suits Balanced skin best. It is the least natural fit for Dry, Combination (dry) skin.
No ingredient in this formula carries a common-irritant flag, making it a reasonable option for reactive skin. A patch test is still recommended, as individual skin reactivity varies.
8 ingredients could feed malassezia: Glyceryl Stearate, Macadamia Ternifolia Seed Oil, Polyglyceryl-10 Laurate, Phytosteryl/behenyl Dimer Dilinoleate, Polyglyceryl-6 Laurate, Butyrospermum Parkii Butter, Helianthus Annuus Seed Oil, Sorbitan Oleate. That describes the yeast's food supply, not a prediction that they will cause a breakout.
It contains Retinol, which are usually reviewed with a doctor during pregnancy. Ask your doctor or midwife before using it.
Yes. Reading the full ingredient list, this formula is fragrance-free.
No. Reading the full ingredient list, this formula is no drying alcohol.
No — it contains Polypropylsilsesquioxane, Vinyl Dimethicone.
No. Reading the full ingredient list, this formula is essential-oil-free.
Yes. Reading the full ingredient list, this formula is paraben-free.
It layers well with Retinoids (retinol, retinal), Copper peptides, Bakuchiol, Niacinamide, Hyaluronic acid, Ceramides. Take more care combining it with AHAs (glycolic, lactic), BHA (salicylic acid), PHAs (gluconolactone), Benzoyl peroxide, Vitamin C (L-ascorbic acid), Azelaic acid — use them in separate routines or on alternate days.
Use it morning and evening, after serums.
It lists 50 ingredients, of which 4 are recorded as actives.
Mary&May, a brand based in Korea.
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