Isntree Hyper Retinol EX 1.0 Serum

Isntree

Hyper Retinol EX 1.0 Serum

face eyes neck serum

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Fit by skin type

General, ingredient-based — not your personalized match.

Dry
65%
Combination (dry)
65%
Balanced
95%
Combination (oily)
75%
Oily
75%

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42
Ingredients
6
Benefits
8
Actives
Find Dupes

Unleash the power of youthful skin with the Isntree Hyper Retinol EX 1.0 Serum, a high-performance well-aging solution designed to combat the visible signs of aging. Boasting an impressive 1% retinol, along with 0.3% retinyl palmitate and 0.6% bakuchiol, this serum is a potent ally in reducing fine lines and wrinkles. Infused with five types of peptides and ceramides, it ensures optimal hydration, while TECA tackles inflammation for a comprehensive skincare approach.

Key Insights

Benefits

6
Anti-Acne
Anti-Aging
Evens Skin Tone
Hydration
Pore Minimizer
Soothing

Active Ingredients

8
Bakuchiol Carrier peptides Ceramides Neuropeptides Retinoids Signal peptides Vitamin B3 (niacinamide) Vitamin B5 (panthenol)

Risks

1
Pregnancy Unsafe

About Hyper Retinol EX 1.0 Serum

Overview

Hyper Retinol EX 1.0 Serum is a cushioning serum from Isntree. The formula is built mainly around hydration. The ingredient list runs to 42 ingredients, each broken down in full below.

Texture and finish

By its ingredient list the formula reads as moderately cushioned — emollient enough to feel like a cream, without the heaviest occlusives near the top. Hydration is handled by Butylene Glycol, Glycerin and Betaine, humectants that pull water into the upper layers of skin rather than sealing it there.

What the formula does

Hydration: Very high. Ingredients that pull and hold water in the upper layers of skin, and here that comes from Butylene Glycol, Glycerin, Betaine and Panthenol.

Soothing: Moderate. Ingredients aimed at visible redness and reactivity, and here that comes from Allantoin, Panthenol, Asiaticoside and Niacinamide.

Barrier support: Moderate. Lipids and repair signals that support skin barrier integrity, and here that comes from Niacinamide, Hydrogenated Lecithin, Panthenol and Ceramide NP.

Brightening: Moderate. Ingredients that act on uneven tone and post-inflammatory marks, and here that comes from Niacinamide, Bakuchiol and Tocopherol.

Who it suits

On richness alone it suits Balanced skin best, and is the least natural fit for Dry and Combination (dry) skin. Nothing in the list is flagged as a common irritant, which is a reasonable starting point for reactive skin — though a patch test is still the only way to know.

What is not in it

Reading the full list, the formula is fragrance-free, essential-oil-free, no drying alcohol, paraben-free, silicone-free and microplastic-free. Those claims come from the ingredient list itself, not from the packaging.

Where it fits in a routine

It can be used morning and evening. In a routine it goes before moisturiser. Tap along the orbital bone with your ring finger; product migrates upward on its own.

This summary is generated from the product's ingredient list. It is not a review, it is not the brand's own marketing claims, and it does not replace advice from a dermatologist.

Pros and cons

Drawn purely from the ingredient list

Pros

  • No fragrance or declared allergens
  • No essential oils
  • No drying alcohol
  • Silicone-free
  • No microplastics
  • Strong humectant content for hydration
  • No common irritants flagged in the list

Things to know

  • 2 ingredients could feed malassezia (fungal acne)
  • Contains ingredients usually flagged for review during pregnancy

Which skin types it suits

Scored on how rich or light the formula reads from its INCI order.

Suitable for

  • Balanced skin

May suit

  • Combination (oily) skin
  • Oily skin

Less suitable for

  • Dry skin
  • Combination (dry) skin

Sensitive skin

No ingredient in this formula carries a common-irritant flag, making it a reasonable option for reactive skin. A patch test is still recommended, as individual skin reactivity varies.

Skin concerns

Based on the curated benefits documented for this product's ingredients.

Helps with

  • Anti-Aging 22 ingredients

    Boosts collagen and cell turnover to reduce fine lines and wrinkles

  • Hydration 22 ingredients

    Attracts and locks in moisture to keep skin plump and dewy

  • Soothing 8 ingredients

    Calms redness, irritation, and inflammation for sensitive skin

  • Evens Skin Tone 2 ingredients

    Brightens and balances complexion for a more uniform appearance

  • Pore Minimizer 2 ingredients

    Tightens and refines the look of enlarged pores

  • Anti-Acne 1 ingredient

    Targets breakouts by reducing bacteria and unclogging pores

Does not target

Blackhead Reducing Dark Spot Fading Oil Control Smooths Bumpy Skin

None of the ingredients in this formula are associated with these benefits. This is not unusual, as most products are designed to target a limited number of concerns.

Key ingredients

The actives, UV filters and benefit-carrying ingredients in this formula, in the order they are listed.

1st on the list, which puts it at an estimated 30–80% of the formula.

Aqua (EU),Deionized Water,Distilled Water,Micromatrix Fractile AN,Onsen-Sui (JPN),Purified Water

Hydration

2nd on the list, which puts it at an estimated 5–20% of the formula.

Butane-1,3-diol (CAS No. 107-88-0/ EC No. 203-529-7) (R)-(-)-butane-1,3-diol” (CAS No. 6290-03-5/ EC No. 228-532-0)

Hydration

3rd on the list, which puts it at an estimated 5–20% of the formula.

Glycerine ;Glycerol (INN); Glycerol (RIFM); Glycerolum (EP); Glycyl Alcohol; 1,2,3-Propanetriol; 1,2,3-Trihydroxypropane

Hydration Anti-Aging
Niacinamide Vitamin B3 (niacinamide)

4th on the list, which puts it at an estimated 2–10% of the formula.

Niacinamide (vitamin B3) is a gentle skincare active that repairs the skin barrier, calms redness, controls oil and evens tone at 2–5%. Official IUPAC name: **3-Pyridinecarboxamide**

Soothing Anti-Aging Pore Minimizer

5th on the list, which puts it at an estimated 2–10% of the formula.

Dibutyl adipate

Hydration

6th on the list, which puts it at an estimated 2–10% of the formula.

Decanoic acid, ester with 1,2,3-propanetriol octanoate; Glycerides, mixed decanoyl and octanoyl

Hydration
Bakuchiol Bakuchiol

7th on the list, which puts it at an estimated 1–5% of the formula.

Bakuchiol (babchi seed extract) is a plant-based retinol alternative that softens wrinkles and fades dark spots with less irritation. IUPAC name: 4-[(1E,3S)-3,7-dimethyl-3-vinylocta-1,6-dien-1-yl]phenol

Soothing Anti-Aging Evens Skin Tone

8th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Ammonium Acryloyldimethyltaurate/VP Copolymer is a copolymer of ammonium acryloyldimethyltaurate and vinylpyrrolidone monomers

Hydration

10th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Lecithins, hydrogenated

Hydration

11th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Methanaminium, 1-carboxy-N,N,N-trimethyl-, hydroxide, inner salt

Hydration

12th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Ethanone, 1-(4-hydroxyphenyl)-,p-Hydroxyacetophenone

Anti-Aging Hydration

13th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Retinol, hexadecanoate

Anti-Aging

Formula analysis

Each axis is scored from the ingredients present and how high up the list they sit.

Hydration Very high

Ingredients that pull and hold water in the upper layers of skin

Barrier support Moderate

Lipids and repair signals that support skin barrier integrity

Antioxidant support Low

Ingredients that mop up free radicals from UV and pollution

Oil control Moderate

Ingredients that moderate sebum or absorb shine

Brightening Moderate

Ingredients that act on uneven tone and post-inflammatory marks

Soothing Moderate

Ingredients aimed at visible redness and reactivity

Cell renewal Low

Retinoids, acids and enzymes that speed surface turnover

Firmness signalling Low

Peptides and growth factors that signal for collagen support

Active and supporting ingredients

"Active" here means an ingredient carrying a recorded active type or a recognised UV filter.

Active ingredients (15)

Supporting ingredients (27)

Solvents, emollients, texture agents and preservatives — the formula that carries the actives.

Water Butylene Glycol Glycerin Dibutyl Adipate Caprylic/capric Triglyceride Ammonium Acryloyldimethyltaurate/vp Copolymer 1,2-hexanediol Hydrogenated Lecithin Betaine Hydroxyacetophenone Sodium Stearoyl Glutamate Tocopherol Allantoin Polysorbate 20 Adenosine Cetearyl Alcohol Disodium Edta Stearic Acid Dipropylene Glycol Hydroxypropyl Cyclodextrin Polydextrose Asiaticoside Madecassic Acid Asiatic Acid Cholesterol Phytosphingosine Ferulic Acid

What is and is not in it

Read from the full ingredient list. A brand's own claim may differ.

Free from

  • Fragrance-free
  • Essential-oil-free
  • No drying alcohol
  • Paraben-free
  • Silicone-free
  • Microplastic-free
  • Sulfate-free
  • Dye-free
  • Oil-free
  • No animal-derived ingredients

What to layer it with

Judged by the same curated rules our routine checker uses. It reads the ingredients, not the label.

Compatible with

  • Retinoids (retinol, retinal)
  • Copper peptides
  • Bakuchiol
  • Niacinamide
  • Hyaluronic acid
  • Ceramides
  • Signal peptides
  • Panthenol
  • Sunscreen

Use with caution

  • AHAs (glycolic, lactic)

    Best kept to separate routines — one in the morning, one at night, or on alternate days.

  • BHA (salicylic acid)

    Best kept to separate routines — one in the morning, one at night, or on alternate days.

  • PHAs (gluconolactone)

    Best kept to separate routines — one in the morning, one at night, or on alternate days.

  • Benzoyl peroxide

    Best kept to separate routines — one in the morning, one at night, or on alternate days.

  • Vitamin C (L-ascorbic acid)

    Can be layered, but the combination raises the irritation risk. Go slowly.

  • Azelaic acid

    Can be layered, but the combination raises the irritation risk. Go slowly.

Where it fits in a routine

Morning Evening
  1. Cleanse
  2. Toning
  3. Eye
  4. Moisturise
  5. Protect

This product is the "Eye" step.

  • Tap along the orbital bone with your ring finger; product migrates upward on its own.

Safety and suitability

Flags to check, not verdicts. None of this is medical advice — if you are pregnant, breastfeeding or treating a skin condition, ask a doctor.

Pregnancy and breastfeeding
Contains Retinyl Palmitate, Retinol, usually reviewed with a doctor during pregnancy.
Fungal acne (malassezia)
2 ingredients could feed malassezia: Retinyl Palmitate, Polysorbate 20. That is about the yeast's food supply, not a prediction that you will break out.
Sensitive and reactive skin
No ingredient in this formula carries a common-irritant flag, making it a reasonable option for reactive skin. A patch test is still recommended, as individual skin reactivity varies.
Recorded ingredient risks
Pregnancy Unsafe

Ingredients by function

Most ingredients do more than one job, so these counts add up to more than the 42 ingredients on the label.

15
Active

Changes how skin behaves rather than how it feels

10
Texture agent

Sets the thickness, spread and stability of the formula

6
Solvent

Dissolves and carries everything else

6
Surfactant

Lifts oil and dirt, or holds oil and water together

5
Antioxidant

Neutralises free radicals from UV and pollution

5
Humectant

Draws water into the upper layers of skin

5
Emollient

Softens and smooths by filling gaps between skin cells

5
Peptide

Amino-acid chains that signal for repair or firmness

3
Occlusive

Forms a film that slows water loss

2
Preservative

Keeps the product free of microbial growth

1
Soothing

Calms visible redness and irritation

1
Chelator

Binds trace metals that would otherwise spoil the formula

Ingredient breakdown

Every ingredient on the label, in order, with what it does and roughly how much of it is likely to be there.

1 Water Solvent
Estimated level
30–80%
Confidence
Moderate — INCI order above the 1% line
Roles
Solvent

1st on the list, which puts it at an estimated 30–80% of the formula.

Aqua (EU),Deionized Water,Distilled Water,Micromatrix Fractile AN,Onsen-Sui (JPN),Purified Water

Hydration
3 scientific references
  • Skin Research and Technology, May 2015, pages 131-136
  • Skin Pharmacology and Applied Skin Physiology, November-December 1999, pages 344-351
  • Journal of Cosmetic Science, September-October 1993, pages 249-262
2 Butylene Glycol Humectant
Estimated level
5–20%
Confidence
Moderate — INCI order above the 1% line
Roles
Humectant, Texture agent, Solvent

2nd on the list, which puts it at an estimated 5–20% of the formula.

Butane-1,3-diol (CAS No. 107-88-0/ EC No. 203-529-7) (R)-(-)-butane-1,3-diol” (CAS No. 6290-03-5/ EC No. 228-532-0)

Hydration
5 scientific references
  • CosmeticsInfoorg, Accessed March 2021, ePublication
  • US Food and Drug Administration Code of Federal Regulations</em>, Accessed March 2021, ePublication
  • International Journal of Toxicology, May 2011, pages 5S-16S
  • Skin Research and Technology, November 2007, pages 417-24
  • Journal of the American College of Toxicology, September 1985, pages 223-248
3 Glycerin Humectant
Estimated level
5–20%
Confidence
Moderate — INCI order above the 1% line
Roles
Humectant, Occlusive, Texture agent, Solvent

3rd on the list, which puts it at an estimated 5–20% of the formula.

Glycerine ;Glycerol (INN); Glycerol (RIFM); Glycerolum (EP); Glycyl Alcohol; 1,2,3-Propanetriol; 1,2,3-Trihydroxypropane

Hydration Anti-Aging
6 scientific references
  • Journal of Pharmaceutical Investigation, March 2021, pages 223-231
  • International Journal of Toxicology, November/December 2019, Volume 38, Supplement 3, pages 6S-22S
  • International Journal of Cosmetic Science, August 2016, ePublication
  • British Journal of Dermatology, July 2008, pages 23-34
  • Journal of Cosmetic Dermatology, June 2007, pages 75-82
  • Proceedings of the National Academy of Sciences, June 2003, pages 7, 360-7, 365
4 Niacinamide Active
Estimated level
2–10%
Confidence
Moderate — INCI order above the 1% line
Roles
Active

4th on the list, which puts it at an estimated 2–10% of the formula.

Niacinamide (vitamin B3) is a gentle skincare active that repairs the skin barrier, calms redness, controls oil and evens tone at 2–5%. Official IUPAC name: **3-Pyridinecarboxamide**

Soothing Anti-Aging Pore Minimizer
15 scientific references
  • International Journal of Dermatology, February 2021, pages 166-173
  • Biomolecules & Therapeutics, July 2019, pages 562-569
  • Experimental Dermatology, February 2019, pages 15-22
  • Dermatologic Therapy, September 2017, ePublication
  • Journal of Investigative Dermatology, May 2017, page S116
  • International Journal of Pharmaceutics, March 2017, pages 158-162
  • Facial Plastic Surgery Clinics of North America, May 2016, pages 145-152
  • Clinical, Cosmetic, and Investigational Dermatology, July 2015, pages 405-412
  • Skin Pharmacology and Physiology, June 2014, pages 311-315
  • International Journal of Pharmacy, January 2013, pages 192-201
  • Dermatoendrocrinology, July 2012, pages 308-319
  • International Journal of Toxicology, September 2005, pages 1-31
  • Dermatologic Surgery, July 2005, pages 860-865
  • International Journal of Cosmetic Science, October 2004, pages 231-238
  • Journal of Cosmetic Dermatology, April 2004, pages 88-93
5 Dibutyl Adipate Emollient
Estimated level
2–10%
Confidence
Moderate — INCI order above the 1% line
Roles
Emollient, Occlusive, Solvent

5th on the list, which puts it at an estimated 2–10% of the formula.

Dibutyl adipate

Hydration
Estimated level
2–10%
Confidence
Moderate — INCI order above the 1% line

6th on the list, which puts it at an estimated 2–10% of the formula.

Decanoic acid, ester with 1,2,3-propanetriol octanoate; Glycerides, mixed decanoyl and octanoyl

Hydration
5 scientific references
  • International Journal of Toxicology, September 2020, pages 34-35
  • Periodica Polytechnica Chemical Engineering, 2014, pages 43-48
  • International Journal of Toxicology, January 2003, pages 4-5
  • Food and Chemical Toxicology, January 2000, pages 79-98
  • Journal of the Society of Cosmetic Chemists, August 1985, pages 303-311
7 Bakuchiol Emollient
Estimated level
1–5%
Confidence
Moderate — INCI order above the 1% line
Roles
Emollient, Active, Antioxidant, Preservative

7th on the list, which puts it at an estimated 1–5% of the formula.

Bakuchiol (babchi seed extract) is a plant-based retinol alternative that softens wrinkles and fades dark spots with less irritation. IUPAC name: 4-[(1E,3S)-3,7-dimethyl-3-vinylocta-1,6-dien-1-yl]phenol

Soothing Anti-Aging Evens Skin Tone
14 scientific references
  • International Journal of Molecular Sciences, July 2020, pages 1-12
  • Pharmacological Research, March 2019, pages 208-213
  • British Journal of Dermatology, February 2019, pages 253-254
  • Oncotarget, March 2016, pages 14, 616-14, 627
  • International Journal of Cosmetic Science, June 2014, pages 221-230
  • Bioscience, Biotechnology, and Biochemistry, 2010, pages 1504-1506
  • The American Journal of Chinese Medicine, 2010, pages 105-114
  • Pharmacognosy Review, January-June 2010, pages 68-76
  • British Journal of Dermatology, 2019 (randomized trial vs retinol: bjd.16918)
  • Phytochemistry Reviews, 2024 (review: s11101-024-09926-y)
  • International Journal of Cosmetic Science, 2026 (review: ics.70116)
  • PubMed 41151326, 2025 (bakuchiol against MRSA)
  • PubMed 38199573, 2024 (antiviral targets PHB2, VDAC1, VDAC2)
  • PubMed 37857572, 2023 (C. elegans lifespan and amyloid-beta)
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Texture agent

8th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Ammonium Acryloyldimethyltaurate/VP Copolymer is a copolymer of ammonium acryloyldimethyltaurate and vinylpyrrolidone monomers

Hydration
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Solvent

9th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Surfactant

10th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Lecithins, hydrogenated

Hydration
4 scientific references
  • International Journal of Toxicology, September 2020, pages 5S-25S
  • Nanocosmetics, June 2019, pages 95–140
  • Current Drug Delivery, 2016, pages 111–120
  • Pharmaceutical Research, February 2013, pages 538–55
11 Betaine Humectant
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Humectant, Texture agent

11th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Methanaminium, 1-carboxy-N,N,N-trimethyl-, hydroxide, inner salt

Hydration
5 scientific references
  • International Journal of Toxicology, 2018, pages 28S-46S
  • Food Science and Biotechnology, October 2017, pages 1391-1397
  • The Journal of Chemical Physics, June 2015, ePublication
  • The American Journal of Clinical Nutrition, September 2004, pages 539-549
  • Skin Research and Technology, February 2003, pages 50-58
12 Hydroxyacetophenone Antioxidant
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Antioxidant

12th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Ethanone, 1-(4-hydroxyphenyl)-,p-Hydroxyacetophenone

Anti-Aging Hydration
4 scientific references
  • Journal of Oleo Science, February 2019, pages 183-191
  • Applied Environmental Microbiology, June 2018, ePublication
  • Journal of Biosciences, May-June 2004, pages 345-353
  • Scientific Reports, April 2021, pages 1–7
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Active

13th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Retinol, hexadecanoate

Anti-Aging Pregnancy Unsafe
7 scientific references
  • Antioxidants, November 2020
  • International Journal of Toxicology, October 2017
  • Journal of Biomedical Nanotechnology, February 2016, pages 394-403
  • Acta Biochimica Polonica, 2015, pages 201-206
  • Journal of Lipid Research, July 2013, pages 1, 731–1, 743
  • Clinical Interventions in Aging, December 2006, pages 327-348
  • Journal of Investigative Dermatology, November 2003, pages 1163-1167
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Surfactant

14th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Sodium hydrogen N-(1-oxooctadecyl)-L-glutamate

Hydration
15 Tocopherol Antioxidant
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Antioxidant

15th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ol; .alpha.-tocopherol; Vitamin E

Anti-Aging Evens Skin Tone Soothing
4 scientific references
  • Journal or Agricultural and Food Chemistry, June 2010, pages 7013-7020
  • Journal of Investigative Dermatology, November 2001, pages 1212-1217
  • Canadian Family Physician, July 2006, pages 855-856
  • Dermatologic Surgery, April 1999, pages 311-315
16 Retinol Active
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Active

16th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Retinol; vitamin A

Anti-Aging Anti-Acne Pore Minimizer Pregnancy Unsafe
10 scientific references
  • Journal of Drugs in Dermatology, September 2019, pages 918-923; and March 2015, pages 271-280
  • Experimental Dermatology, August 2019, pages 906-913
  • Archives of Dermatological Research, May 2017, pages 275-283
  • International Journal of Cosmetic Science, February 2017, pages 56-65
  • Dermatology, May 2014, pages 314-325
  • Dermatoendocrinology, July 2012, issue 3, pages 308-319
  • Toxicological Research, March 2010, pages 61-66
  • Archives of Dermatology, May 2007, pages 606-612
  • The Journal of Pathology, January 2007, issue 2, pages 241-251
  • Clinical Interventions in Aging, December 2006, pages 327-348
17 Allantoin Occlusive
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Occlusive, Soothing

17th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Urea, (2,5-dioxo-4-imidazolidinyl)-

Soothing
8 scientific references
  • Chemistry Series, March 2020, pages 7-21
  • Molecules, June 2019, pages 1-33
  • European Journal of Pharmacology, February 2018, pages 68-78
  • Journal of the American Academy of Dermatology, June 2017, Volume 76, Issue 2, Supplement 1
  • Pharmacognosy Review, Volume 5, July-December 2011
  • International Journal of Toxicology, May 2010, Supplement, pages 84S-97S
  • Journal of Occupational Medicine and Toxicology, October 2008, ePublication
  • https://wwwaccessdatafdagov/scripts/cdrh/cfdocs/cfcfr/CFRSearchcfm?CFRPart=347&showFR=1
18 Panthenol Active
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Active

18th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (2R)-; dl-Panthenol

Hydration Soothing
7 scientific references
  • The Linus Pauling Institute, Oregon State University, Accessed April 2021, ePublication
  • International Journal of Cosmetic Science, December 2019, pages 534-547
  • Journal of Cosmetic Dermatology, January 2019, pages 346-354
  • Cosmetic Ingredient Review, March 2018, pages 1-51
  • The Journal of Dermatological Treatment, August 2017, pages 173-180
  • Journal of Cosmetic Science, August 2011, pages 361-370
  • American Journal of Clinical Dermatology, Volume 3, 2002, pages 427-433
19 Polysorbate 20 Surfactant
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Surfactant

19th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Sorbitan, monododecanoate, poly(oxy-1,2-ethanediyl) derivs.

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

20th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

6-Amino-9-beta-D-ribofuranosyl-9H-purine

Soothing
8 scientific references
  • PubChem, Accessed May 2021, ePublication
  • Cosmetic Ingredient Review, September 2020, pages 1-38
  • Experimental Dermatology, August 2014, pages 553-554
  • Journal of Investigative Dermatology, August 2011, pages 526-546
  • International Journal of Cosmetic Science, December 2006, pages 447-451
  • British Journal of Pharmacology, October 2008, issue 4, pages 475-486
  • PloS One, May 2008 (ePublication)
  • >International Journal of Cosmetic Science, August 2006, pages 447-451
21 Cetearyl Alcohol Emollient
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Emollient, Surfactant, Texture agent

21st on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Alcohols, C16-18

Hydration
4 scientific references
  • CosmeticsInfoorg, Accessed March 2021, ePublication
  • FDA Cosmetic Labeling Claims, August 2020, ePublication
  • Journal of the Society of Cosmetic Scientists of Korea, June 2009, pages 103-110
  • Journal of the American College of Toxicology, 1988, pages 359-413
22 Disodium Edta Texture agent
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Texture agent, Chelator

22nd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Disodium dihydrogen ethylenediaminetetraacetate

23 Stearic Acid Emollient
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Emollient, Surfactant, Texture agent

23rd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Stearic acid

Hydration
4 scientific references
  • Cosmetic Ingredient Review, May 2019, pages 1-61
  • International Journal of Cosmetic Science, August 2008, page 310
  • Therapeutics for the Clinician, May 2005, pages 317-324
  • Journal of Cosmetic Science, December 2003, pages 559-568
24 Dipropylene Glycol Texture agent
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Texture agent, Solvent

24th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

1,1'-Oxydipropan-2-ol; Oxydipropan-2-ol; Hydroxypropyloxypropanol

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

25th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

.beta.-Cyclodextrin, 2-hydroxypropyl ethers

26 Polydextrose Humectant
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Humectant, Texture agent

26th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Random polymer of D-glucose condensation

Hydration
27 Ceramide NP Active
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Active

27th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Ceramide NP,1,3,4-Octadecanetriol, 2-Octadecanamide,Stearoyl-C18-Phytosphingosine,Stearoyl-4-Hydroxysphinganine

Hydration Anti-Aging
11 scientific references
  • International Journal of Toxicology, 2020, pages 5S-25S
  • International Journal of Molecular Sciences, August 2019, pages 1-15
  • Skin Pharmacology and Physiology, 2016, pages 135-147
  • Biochimica et Biophysica Acta, October 2014, pages 2473-2483
  • Journal of the American Academy of Dermatology, July 2014, pages 177-184
  • Journal of Lipid Research, July 2008, pages 1, 466-1, 476
  • Journal of Lipid Research, September 2007, pages 1936-1943
  • American Journal of Clinical Dermatology, 2003, pages 107-129
  • Contact Dermatitis, June 2002, pages 331-338
  • Journal of Investigative Dermatology, November 2001, pages 1, 126-1, 136
  • Skin Pharmacology and Applied Skin Physiology, September-October 2001, pages 261-271
28 Asiaticoside Antioxidant
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Antioxidant

28th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Urs-12-en-28-oic acid, 2,3,23-trihydroxy-, O-6-deoxy-alpha-L-mannopyranosyl-(1->4)-O-beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranosyl ester (2alpha, 3beta, 4alpha)-

Anti-Aging Soothing
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

29th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Urs-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-, (2alpha,3beta,4alpha,6beta)-

Anti-Aging Soothing
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

30th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

(2.alpha.,3.beta.,4.alpha.)-2,3,23-Trihydroxyurs-12-en-28-oic acid

Anti-Aging
31 Ceramide NS Active
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Active

31st on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Ceramide NG,Ceramide NS,1,3-Hexadecanediol, 2-Hexadecanamide,Palmitoyl-C16-Dihydrosphingosine,1-Stearoyl-C18-Sphingosine

Hydration Anti-Aging
9 scientific references
  • International Journal of Toxicology, 2020, pages 5S-25S
  • PLoS ONE, October 2018, pages 1-18
  • Scientific Reports, November 2015, pages 1-11
  • Biochimica et Biophysica Acta, October 2014, pages 2473-2483
  • Journal of the American Academy of Dermatology, July 2014, pages 177-184
  • Journal of Lipid Research, September 2007, pages 1936-1943
  • American Journal of Clinical Dermatology, Volume 4, 2003, pages 107-129
  • Journal of Investigative Dermatology, November 2001, pages 1126-1136
  • Skin Pharmacology and Applied Skin Physiology, September-October 2001, pages 261-271
32 Cholesterol Emollient
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Emollient, Surfactant, Texture agent

32nd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Cholest-5-en-3-ol (beta)-

Hydration Anti-Aging
4 scientific references
  • Frontiers in Bioengineering and Biotechnology, August 2015, pages 1-6
  • Journal of Cosmetic Dermatology, July 2007, pages 239-242
  • Journal of Structural Biology, June 2007, pages 386-400
  • International Journal of Toxicology, 2006, pages 1-89
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line

33rd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

1,3,4-Octadecanetriol, 2-amino-, (2S, 3S, 4R)-

Anti-Aging Hydration
6 scientific references
  • Journal of Dermatological Science, January 2020, Volume 97, Issue 1, pages 2-8
  • Archives of Dermatological Research, December 2017, Volume 309, Issue 10, pages 795-803
  • Biochimica et Biophysica Acta: Biomembranes, May 2017, Volume 1859, Issue 5, pages 824-834
  • International Journal of Cosmetic Science, June 2007, Volume 29, Issue 3, pages 181-190
  • Molecular Medicine, January-March 2006, pages 17-24
  • Journal of Investigative Dermatology, October 2003, issue 5, pages 1135–1137
34 Ferulic Acid Antioxidant
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Antioxidant, Preservative

34th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

4-Hydroxy-3-methoxycinnamic acid

Anti-Aging
8 scientific references
  • Aesthetic Plastic Surgery, October 2020, pages 281-288
  • Acta Biologica Marisiensis, December 2018, pages 53-60
  • Food and Chemical Toxicology, March 2014, pages 185-195
  • The Journal of Nutritional Biochemistry, May 2012, pages 443-451
  • International Journal of Pharmaceutics, October 2010, pages 44-51
  • Journal of Cosmetic Dermatology, August 2008, pages 290-297
  • Journal of Clinical Biochemistry and Nutrition, March 2007, pages 92-100
  • Journal of Investigative Dermatology, October 2005, pages 826-832
35 Ceramide AS Active
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Active

35th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Ceramide AS

Anti-Aging Hydration
2 scientific references
  • UL Prospector, Accessed February 2023, Webpage 9 American Journal of Clinical Dermatology, July 2021, pages 853-866
  • International Journal of Toxicology, Nov-Dec 2020, pages 52-25S
36 Ceramide AP Active
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Active

36th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

1,3,4-Octadecanetriol, 2-(2-Hydroxy) Stearamide

Hydration Anti-Aging
10 scientific references
  • International Journal of Toxicology,  2020, pages 5S-25S
  • International Journal of Molecular Sciences, August 2019, pages 1-15
  • Biochimica et Biophysica Acta, October 2014, pages 2473-2483
  • Journal of the American Academy of Dermatology, July 2014, pages 177-184
  • Pharmaceutical Research, November 2012, pages 538-551
  • Journal of Lipid Research,  July 2008, pages 1, 466-1, 476
  • Journal of Lipid Research,  September 2007, pages 1936-1943
  • American Journal of Clinical Dermatology, 2003, pages 107-129
  • Journal of Investigative Dermatology,  November 2001, pages 1, 126-1, 136
  • Skin Pharmacology and Applied Skin Physiology, September-October 2001, pages 261-271
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Active, Peptide

37th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Copper Tripeptide-1 is a copper complex of Tripeptide-1

Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Humectant, Active, Peptide

38th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Acetyl hexapeptide-8 is the synthetic peptide consisting of arginine, methionine, and acetylated glutamic acid residues

Anti-Aging Hydration
6 scientific references
  • Cosmetics, November 2020, Issue 7, Volume 4, page 91
  • La Clinica Terapeutica, November 2020, pages e539-e548
  • https://wwwcir-safetyorg/sites/default/files/AcetylHexapeptide-8pdf
  • Cutaneous and Ocular Toxicology, March 2015, pages 46-52
  • European Journal of Pharmaceutical Sciences, February 2015, pages 27-35
  • Dermatologic Therapy, September-October 2007, issue 5, pages 343-349
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Active, Peptide

39th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Lysine, synthetic pentapeptide with serine, and threonine, hexadecanoyl derivatives

Anti-Aging
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Active, Peptide

40th on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Palmitoyl Tetrapeptide-7 is the reaction product of palmitic acid and Tetrapeptide-7

Anti-Aging
5 scientific references
  • Cosmetics, November 2020, ePublication
  • International Journal of Toxicology, Volume 37, Supplement 3, November 2018, pages 90S–102S
  • Journal of Cosmetic Dermatology, June 2015, pages 152–160
  • Molecular Pharmaceutics, March 2013, pages 1, 063-1, 069
  • Plastic Surgical Nursing, April 2012, pages 71–72
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Active, Peptide

41st on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

L-Lysine, N-(1-oxohexadecyl)glycyl-L-histidyl-

Anti-Aging
4 scientific references
  • International Journal of Toxicology, November 2018, pages 90S-102S
  • Cosmetics, May 2017, pages 1-14
  • Experimental and Therapeutic Medicine, August 2016, pages 1, 171-1, 176
  • International Journal of Cosmetic Science, June 2000, pages 207-218
42 Ceramide EOP Active
Estimated level
under 1%
Confidence
Moderate — listed below the 1% line
Roles
Active

42nd on the list, below the 1% line — present at under 1%, which for most ingredients is the level they work at.

Ceramide EOP,1,3,4-Octadecanetriol, 2-Stearoyloxyheptacosamide,Stearoyloxyheptacosanoyl-C18-Phytosphingosine,Stearoyloxyheptacosanoyl-4-Hydroxysphinganine

Hydration Anti-Aging
9 scientific references
  • International Journal of Toxicology,  2020, pages 5S-25S
  • International Journal of Molecular Sciences, August 2019, pages 1-15
  • Biochimica et Biophysica Acta, October 2014, pages 2473-2483
  • Journal of the American Academy of Dermatology, July 2014, pages 177-184
  • Journal of Lipid Research,  July 2008, pages 1, 466-1, 476
  • Journal of Lipid Research,  September 2007, pages 1936-1943
  • American Journal of Clinical Dermatology,  2003, pages 107-129
  • Journal of Investigative Dermatology,  November 2001, pages 1, 126-1, 136
  • Skin Pharmacology and Applied Skin Physiology, September-October 2001, pages 261-271

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Frequently asked questions

What ingredients are in Hyper Retinol EX 1.0 Serum?

WATER, BUTYLENE GLYCOL, GLYCERIN, NIACINAMIDE, DIBUTYL ADIPATE, CAPRYLIC/CAPRIC TRIGLYCERIDE, BAKUCHIOL, AMMONIUM ACRYLOYLDIMETHYLTAURATE/VP COPOLYMER, 1,2-HEXANEDIOL, HYDROGENATED LECITHIN, BETAINE, HYDROXYACETOPHENONE, RETINYL PALMITATE, SODIUM STEAROYL GLUTAMATE, TOCOPHEROL, RETINOL, ALLANTOIN, PANTHENOL, POLYSORBATE 20, ADENOSINE, CETEARYL ALCOHOL, DISODIUM EDTA, STEARIC ACID, DIPROPYLENE GLYCOL, HYDROXYPROPYL CYCLODEXTRIN, POLYDEXTROSE, CERAMIDE NP, ASIATICOSIDE, MADECASSIC ACID, ASIATIC ACID, CERAMIDE NS, CHOLESTEROL, PHYTOSPHINGOSINE, FERULIC ACID, CERAMIDE AS, CERAMIDE AP, COPPER TRIPEPTIDE-1, ACETYL HEXAPEPTIDE-8, PALMITOYL PENTAPEPTIDE-4, PALMITOYL TETRAPEPTIDE-7, PALMITOYL TRIPEPTIDE-1, CERAMIDE EOP.

What are the active ingredients in Hyper Retinol EX 1.0 Serum?

NIACINAMIDE, BAKUCHIOL, RETINYL PALMITATE, RETINOL, PANTHENOL, CERAMIDE NP, CERAMIDE NS, CERAMIDE AS, CERAMIDE AP, COPPER TRIPEPTIDE-1, ACETYL HEXAPEPTIDE-8, PALMITOYL PENTAPEPTIDE-4, PALMITOYL TETRAPEPTIDE-7, PALMITOYL TRIPEPTIDE-1, CERAMIDE EOP.

How do I use Hyper Retinol EX 1.0 Serum?

During evening care, apply 1 to 2 drops to hand and tap with fingertips from inside out, let absorb. Limit initial use to three times per week; gradually increase frequency to every other night, use as tolerated. After cleansing, at the moisturizer step, apply 1–2 drops to areas of concern or spread over the entire face.

What skin types is Hyper Retinol EX 1.0 Serum good for?

Judged on how rich the formula reads from its ingredient list, it suits Balanced skin best. It is the least natural fit for Dry, Combination (dry) skin.

Is Hyper Retinol EX 1.0 Serum good for sensitive skin?

No ingredient in this formula carries a common-irritant flag, making it a reasonable option for reactive skin. A patch test is still recommended, as individual skin reactivity varies.

Is Hyper Retinol EX 1.0 Serum fungal acne safe?

2 ingredients could feed malassezia: Retinyl Palmitate, Polysorbate 20. That describes the yeast's food supply, not a prediction that they will cause a breakout.

Can I use Hyper Retinol EX 1.0 Serum while pregnant?

It contains Retinyl Palmitate, Retinol, which are usually reviewed with a doctor during pregnancy. Ask your doctor or midwife before using it.

Is Hyper Retinol EX 1.0 Serum fragrance free?

Yes. Reading the full ingredient list, this formula is fragrance-free.

Does Hyper Retinol EX 1.0 Serum contain alcohol?

No. Reading the full ingredient list, this formula is no drying alcohol.

Is Hyper Retinol EX 1.0 Serum silicone free?

Yes. Reading the full ingredient list, this formula is silicone-free.

Does Hyper Retinol EX 1.0 Serum contain essential oils?

No. Reading the full ingredient list, this formula is essential-oil-free.

Is Hyper Retinol EX 1.0 Serum paraben free?

Yes. Reading the full ingredient list, this formula is paraben-free.

What can I layer with Hyper Retinol EX 1.0 Serum?

It layers well with Retinoids (retinol, retinal), Copper peptides, Bakuchiol, Niacinamide, Hyaluronic acid, Ceramides. Take more care combining it with AHAs (glycolic, lactic), BHA (salicylic acid), PHAs (gluconolactone), Benzoyl peroxide, Vitamin C (L-ascorbic acid), Azelaic acid — use them in separate routines or on alternate days.

When should I apply Hyper Retinol EX 1.0 Serum?

Use it morning and evening, before moisturiser.

How many ingredients does Hyper Retinol EX 1.0 Serum have?

It lists 42 ingredients, of which 15 are recorded as actives.

Who makes Hyper Retinol EX 1.0 Serum?

Isntree.

Brand
Isntree

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